Mek
Mostrando 1-12 de 509 artigos, teses e dissertações.
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1. Polydatin protects H9c2 cells from hypoxia-induced injury via up-regulating long non-coding RNA DGCR5
Polydatin (PD), a monocrystalline polyphenolic drug mainly found in the roots of Polygonum cuspidatum, has various pharmacological activities. Long non-coding RNAs (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) was found to participate in the suppression of multiple cancers. Here, we proposed to study the effect of PD on myocardial infarction (MI)
Braz J Med Biol Res. Publicado em: 05/12/2019
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2. Baicalein restrains proliferation, migration, and invasion of human malignant melanoma cells by down-regulating colon cancer associated transcript-1
Baicalein (BAI) is an acknowledged flavonoids compound, which is regarded as a useful therapeutic pharmaceutical for numerous cancers. However, its involvement in melanoma is largely unknown. This study aimed to examine the anti-melanoma function of BAI and unraveled the regulatory mechanism involved. A375 and SK-MEL-28 were treated with BAI for 24 h. Then,
Braz J Med Biol Res. Publicado em: 25/11/2019
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3. Regulation of ghrelin receptor by microbial and inflammatory signals in human osteoblasts
Abstract: Recently, it has been suggested that the anti-inflammatory hormone ghrelin (GHRL) and its receptor GHS-R may play a pivotal role in periodontal health and diseases. However, their exact regulation and effects in periodontitis are not known. The aim of this in-vitro study was to investigate the effect of microbial and inflammatory insults on the GHS
Braz. oral res.. Publicado em: 25/04/2019
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4. Molecular biology of human epidermal receptors, signaling pathways and targeted therapy against cancers: new evidences and old challenges
ABSTRACT Human epidermal receptors (HER1/2/3/4) belong to the class of receptor-type tyrosine kinases. After binding a ligand, dimerization, it will ocurr activation of intracellular kinases after two-dimensional and cytoplasmic tail reciprocal transphosphorylation. This transphosphorylation recruits signaling pathways such as Ras/Raf/MEK/Erk1-2, PI3-K/AKT a
Braz. J. Pharm. Sci.. Publicado em: 20/07/2017
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5. Tratamento de melanoma avançado - Um panorama em transformação
Resumo Após décadas de ostracismo, os recentes avanços no tratamento do melanoma trouxeram uma nova realidade para pacientes, médicos e pesquisadores. Enquanto anticorpos monoclonais voltados a moléculas envolvidas na modulação da interação entre células do melanoma e do sistema imune consolidaram o uso da “imunoterapia”, um melhor conhecimento
Rev. Assoc. Med. Bras.. Publicado em: 2017
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6. ERKs and mitochondria-related pathways are essential for glycyrrhizic acid-mediated neuroprotection against glutamate-induced toxicity in differentiated PC12 cells
The present study focuses on the neuroprotective effect of glycyrrhizic acid (GA, a major compound separated from Glycyrrhiza Radix, which is a crude Chinese traditional drug) against glutamate-induced cytotoxicity in differentiated PC12 (DPC12) cells. The results showed that GA treatment improved cell viability and ameliorated abnormal glutamate-induced alt
Braz J Med Biol Res. Publicado em: 25/07/2014
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7. Cutaneous melanoma: new advances in treatment
Cutaneous melanoma is a challenge to treat. Over the last 30 years, no drug or combination of drugs demonstrated significant impact to improve patient survival. From 1995 to 2000, the use of cytokines such as interferon and interleukin become treatment options. In 2011, new drugs were approved by the U.S. Food and Drug Administration, including peginterferon
An. Bras. Dermatol.. Publicado em: 2014-04
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8. Fatores prognósticos em pacientes com carcinoma epidermóide de laringe estádio clínico T3 tratados por cirurgia, radioterapia ou associações terapêuticas / Prognostic factors in patients with cT3 laryngeal squamous cell carcinoma treated by surgery, radiation or multimodality treatment
The decreased survival recorded for patients with laryngeal cancer in the last decades may be related to changes in patterns of management; in literature a recent debate has been dedicated to the management of clinical stage T3 due to the disseminated use of organ preservation strategies (Hoffman, 2006). Although inclusion criteria for organ preservation gro
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/01/2013
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9. Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells
BACKGROUND: Mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in response to viral infection. The aim of this study was to explore the function and mechanism of MAPK signaling pathway in enterovirus 71 (EV71) infection of human rhabdomyosarcoma (RD) cells. METHODS: Apoptosis of RD cells was observed using annexin V-FITC/PI bin
Braz J Infect Dis. Publicado em: 2013-08
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10. Study of Vaccinia and Cowpox viruses' replication in Rac1-N17 dominant-negative cells
Interfering with cellular signal transduction pathways is a common strategy used by many viruses to create a propitious intracellular environment for an efficient replication. Our group has been studying cellular signalling pathways activated by the orthopoxviruses Vaccinia (VACV) and Cowpox (CPXV) and their significance to viral replication. In the present
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-08
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11. Effects of the adipokine chemerin on the vascular reactivity: analysis in the rat aorta / Efeito da adipocina chemerin sobre a reatividade vascular: análise em aortas de rato
Embora seja na obesidade onde se observa hipertrofia e hiperplasia dos adipócitos e aumento da síntese e liberação de adipocinas, condição associada com resistência à insulina e disfunção endotelial, é de suma importância entender os efeitos biológicos de adipocinas, mais especificamente da adipocina chemerin, em condições não patológicas. O
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/09/2012
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12. Estudo funcional de células derivadas do periósteo portadoras da mutação p.S252W em FGFR2: alterações fenotípicas e moleculares / Functional analysis of periosteum derived cells bearing the FGFR2 p.S252W mutation: phenotypical and molecular alterations
Mutações do tipo ganho de função em FGFR2 causam a síndrome de Apert, uma doença rara caracterizada por craniossinostose e defeitos ósseos nos membros devidos a anormalidades na diferenciação e remodelamento ósseos. Apesar do periósteo ser uma importante fonte de células durante o remodelamento ósseo, seu papel nas craniossinostoses ainda é pou
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2012