Mefloquine Enantiomers
Mostrando 1-3 de 3 artigos, teses e dissertações.
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1. Aplicação da microextração em fase liquida na análise de alguns fármacos antimaláricos e respectivos metabólitos em plasma / Application of liquid-phase microextration to the analysis of some antimalarial drugs and their metabolites in plasma
Currently, malaria is the main parasitic infection and shows worldwide distribution. Among therapeutic options used, chloroquine (CQ), mefloquine (MQ) and, more recently, artemether (ART) have been standing out. According to the literature, pharmacokinetic studies of these drugs have been hampered by the lack of proper methods of analysis in biological fluid
Publicado em: 2009
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2. Enantioselective analysis of mefloquine in plasma: evaluation on the liquid-phase microextration technique / Análise enantiosseletiva da mefloquina em plasma: avaliação da técnica de microextração em fase líquida
A mefloquina (MQ), fármaco utilizado na profilaxia e tratamento da malária ocasionada por Plasmodium falciparum resistente à cloroquina, é comercializada na forma racêmica. Apresenta disposição cinética estereosseletiva e ação farmacológica diferencial entre os enantiômeros. A maioria dos métodos analíticos desenvolvidos para análise do fárma
Publicado em: 2006
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3. Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737.
The S,S enantiomer of the bisquinoline trans-N1,N2-bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamine, Ro 47-7737, is significantly more potent against chloroquine-resistant Plasmodium falciparum than the R,R enantiomer and the previously described racemate. Both the enantiomers and the racemate are more potent inhibitors of heme polymerization than chloroqui