Mediated Action
Mostrando 13-24 de 2177 artigos, teses e dissertações.
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13. A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems
Abstract Background Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central nervous system and investigated the possible involvement of opioid and cannabinoid systems in i
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 19/01/2017
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14. Effect of mitochondrial potassium channel on the renal protection mediated by sodium thiosulfate against ethylene glycol induced nephrolithiasis in rat model
Purpose: Sodium thiosulfate (STS) is clinically reported to be a promising drug in preventing nephrolithiasis. However, its mechanism of action remains unclear. In the present study, we investigated the role of mitochondrial KATP channel in the renal protection mediated by STS. Materials and Methods: Nephrolithiasis was induced in Wistar rats by administra
Int. braz j urol.. Publicado em: 2015-12
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15. The role of melatonin in diabetes: therapeutic implications
Melatonin referred as the hormone of darkness is mainly secreted by pineal gland, its levels being elevated during night and low during the day. The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2). It decreases insulin secretion by inhibiting cAMP and cGMP pathways but activates the phospholipaseC/IP3 path
Arch. Endocrinol. Metab.. Publicado em: 28/08/2015
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16. Combined administration of silymarin and vitamin C stalls acetaminophen-mediated hepatic oxidative insults in Wistar rats
Oxidative insult by free radicals has been implicated in drug-induced hepatic damage and this has resulted in frequent episodes of liver disorders. Therapeutic efficacy of antioxidants may provide a possible solution to this menace. This study was carried out to investigate the effect of combined administration of silymarin and vitamin C in rescuing acetamin
Rev. bras. farmacogn.. Publicado em: 2015-02
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17. Electroacupuncture ameliorates experimental colitis induced by TNBS through activation of interleukin-10 and inhibition of iNOS in mice
PURPOSE: To study the anti-inflammatory actions of electroacupuncture (EAc) on an experimental colitis model in mice. METHODS: Thirty-eight male Swiss mice, divided in five groups, were subjected to induction of colitis by TNBS in 50% ethanol. Saline (SAL) and ethanol (ETNL) groups served as controls. TNBS+EAc and TNBS+ dexamethasone subgroups were treated
Acta Cir. Bras.. Publicado em: 2014-12
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18. Detection of multi drug resistant bacteria in major hospitals in Kano, North-West, Nigeria
Two major hospitals in Kano, North West Nigeria have recorded increasing resistance of clinical pathogens to broad spectrum β lactams, mediated by extended spectrum β- lactamase (ESβL) and non ESBLs. A study was therefore undertaken to determine the occurrence and prevalence of plasmid and chromosomal mediated AmpC βL and carbapenemase in addition to alr
Braz. J. Microbiol.. Publicado em: 2014-09
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19. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children
BACKGROUND:Neuraminidase inhibitors (NIs) are stockpiled and recommended by public health agencies for treating and preventing seasonal and pandemic influenza. They are used clinically worldwide.OBJECTIVE:To describe the potential benefits and harms of NIs for influenza in all age groups by reviewing all clinical study reports of published and unpublished ra
Sao Paulo Med. J.. Publicado em: 2014
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20. SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway
Chronic inflammation induced by amyloid-beta (Aβ) plays a key role in the development of age-related macular degeneration (AMD), and matrix metalloproteinase-9 (MMP-9), interleukin (IL)-6, and IL-8 may be associated with chronic inflammation in AMD. Sirtuin 1 (SIRT1) regulates inflammation via inhibition of nuclear factor-kappa B (NF-κB) signaling, and res
Braz J Med Biol Res. Publicado em: 2013-08
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21. Plant regeneration and Agrobacterium-mediated transformation of Achyranthes bidentata using cotton EREBP gene
The aim of this work was to study the plant regeneration and Agrobacterium-mediated transformation of Achyranthes bidentata using cotton EREBP gene. Results showed that the callus induction rate of stems from A. bidentata was the highest (100%) and bud was in approximately 70% of calli from stems. However bud differentiation rate of the callus from leaves an
Braz. arch. biol. technol.. Publicado em: 2013-06
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22. GABA and glutamate transporters: new events and function in the vertebrate retina
The neural retina is a highly complex tissue composed of excitatory and inhibitory neurons and glial cells. Glutamate, the main excitatory neurotransmitter, mediates information transfer from photoreceptors, bipolar cells, and ganglion cells, whereas interneurons, mainly amacrine and horizontal cells, use γ-aminobutyric acid (GABA), the main inhibitory neur
Psychol. Neurosci.. Publicado em: 2013
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23. Ação do microRNA-7 sobre vias de sinalização mediadas por EGF: estudo funcional em linhagem celular de carcinoma oral e em queratinócitos normais. / The action of microRNA-7 on signaling pathways mediated by EGF: a functional study using oral squamous cell carcinoma cell line and normal keratinocytes.
MicroRNAs regulam processos celulares e tumorigênese. O carcinoma epidermoide de cabeça e pescoço (CECP) é a sexta neoplasia mais comum no mundo e não existe consenso sobre características moleculares representativas deste tumor. O receptor de fator de crescimento epidemal (EGFR), bem como efetores de sua via de sinalização, podem ser regulados por m
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/10/2012
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24. Um estudo sobre a interação dos sistemas colinérgico nicotínico e dopaminérgico na persistência de memórias aversivas
Long-term memory (LTM) storage requires activation of the ventral tegmental area (VTA)- hippocampus dopaminergic loop and synthesis of brain-derived neurotrophic factor (BDNF) late after learning (Bekinschtein et al., 2007; Rossato et al., 2009). Nicotinic acetylcholine receptors (nAChR) modulate VTA function. Therefore, we analyzed the involvement of these
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2012