Mechanical Nociceptive Threshold
Mostrando 13-23 de 23 artigos, teses e dissertações.
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13. Bradykinin-induced modulation of the response behaviour of different types of feline group III and IV muscle receptors.
1. In order to test the hypothesis that bradykinin has a sensitizing action on muscle receptors (e.g. during a myositis), the response properties of single group III and IV afferent units from the cat gastrocnemius-soleus muscle were compared before and after infiltration of their receptive fields with a bradykinin solution. According to their responses to g
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14. Distinct neurochemical features of acute and persistent pain
To address the neurochemistry of the mechanisms that underlie the development of acute and persistent pain, our laboratory has been studying mice with deletions of gene products that have been implicated in nociceptive processing. We have recently raised mice with a deletion of the preprotachykinin-A gene, which encodes the peptides substance P (SP) and
The National Academy of Sciences.
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15. Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor.
Nerve growth factor (NGF) in the mouse submandibular gland undergoes cleavage of its amino-terminal octapeptide when salivation is induced by epinephrine. The significance of this event is uncertain; cleaved NGF demonstrates bioactivity and no function has been attributed to the octapeptide produced (NGF-OP; Ser-Ser-Thr-His-Pro-Val-Phe-His). Enzyme inhibitio
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16. Ischaemia-sensitive sympathetic afferents innervating the gastrointestinal tract function as nociceptors in cats.
1. Activation of sympathetic visceral afferents during mesenteric ischaemia induces visceral pain and reflexly excites the cardiovascular system. The present study investigated the differential responses of ischaemically sensitive and insensitive sympathetic C fibre afferents to graded distension of the gastrointestinal tract. 2. Single-unit activity of C fi
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17. Segmental Neuropathic Pain Does Not Develop in Male Rats with Complete Spinal Transections
In a previous study using male rats, a correlation was found between the development of “at-level” allodynia in T6-7 dermatomes following severe T8 spinal contusion injury and the sparing of some myelinated axons within the core of the lesion epicenter. To further test our hypothesis that this sparing is important for the expression of allodynia and the
Mary Ann Liebert.
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18. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptors
Galanin is a 29-aa neuropeptide with a complex role in pain processing. Several galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. Here, we describe a generation of a specific galanin R2 (GalR2) agonist, AR-M1896, and its application in studies of a rat neuropathic pain model (Bennett). The res
National Academy of Sciences.
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19. Excitatory amino acid receptor-mediated neurotransmission from cutaneous afferents in rat dorsal horn in vitro.
1. The cutaneous mechanoreceptive fields (RFs) of forty-two lumbar dorsal horn neurones have been examined intracellularly using the hemisected spinal cord-hindlimb preparation of 10 to 14-day-old rats. The neurones were classified into three groups on the basis of their excitatory responses to innocuous and noxious mechanical stimulation; the majority (25/4
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20. Properties of afferent nerve fibres supplying the saphenous vein in the cat.
1. We examined the responses of primary afferent neurones supplying a vascularly isolated segment of the saphenous vein to mechanical and chemical stimuli in anaesthetized cats. Activity was recorded from centrally cut axons of afferent nerve fibres which were isolated from the saphenous nerve near its junction with the femoral nerve. 2. A total of thirty un
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21. Excitation by irritant chemical substances of sensory afferent units in the cat's cornea.
1. Single-unit electrical activity was recorded from thin myelinated sensory nerve fibres innervating the cornea of deeply anaesthetized cats. 2. Based on their responses to mechanical (calibrated von Frey hairs), chemical (10 mM-acetic acid and/or 616 mM-NaCl) and thermal (ice-cold or heat up to 51 degrees C) stimuli, corneal A delta fibres were classified
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22. Reduction of the bradykinin-induced activation of feline group III and IV muscle receptors by acetylsalicylic acid.
1. In chloralose-anaesthetized cats, the influence of systemically or locally applied acetylsalicylic acid (ASA) on the responses of thin-fibre muscle receptors to close-arterial injections of bradykinin was studied. 2. Many of the slowly conducting (group III and IV) muscle afferents had a background activity of low frequency. This discharge was either unaf
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23. Responses in muscle afferent fibres of slow conduction velocity to contractions and ischaemia in the cat.
The aim of the study was to find out to what extent muscle receptors with slowly conducting afferent fibres (group III and IV) are activated by muscular contractions of moderate force, and what kind of muscle afferents could mediate the pain of ischaemic exercise. In chloralose-anaesthetized cats, the impulse activity of single afferent units from the tricep