Mdma
Mostrando 25-36 de 43 artigos, teses e dissertações.
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25. Anestesia e o usuário de Ecstasy
JUSTIFICATIVA E OBJETIVOS: Nos últimos anos o número de novos usuários de agentes ilícitos tem aumentado de forma significativa em todo o mundo. A maconha e a cocaína, além do álcool e do tabaco, têm sido os agentes citados com freqüência, porém houve um aumento significativo de usuários de outros agentes psicoestimulantes ou alucinógenos, como
Revista Brasileira de Anestesiologia. Publicado em: 2006-04
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26. Validação de método para determinação de 3,4-metilenodioximetanfetamina (MDMA) em comprimidos de ecstasy por cromatografia em fase gasosa
O ecstasy é comercializado, de maneira ilegal, normalmente sob a forma de comprimidos, com cores, aspectos, dimensões e logotipos variados. Quimicamente, é a metilenodioximetanfetamina (MDMA), um composto sintético com propriedades estimulante central e alucinogênicas. Devido à grande expansão do abuso de ecstasy, também tem aumentado o número de ca
Revista Brasileira de Ciências Farmacêuticas. Publicado em: 2004-03
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27. "Quantificação de MDMA em amostras de ecstasy por cromatografia em fase gasosa (GC/NPD)" / Quantification of MDMA in ecstasy samples by gas chromatography (GC/NPD)
Quimicamente, o ecstasy é a 3,4-metilenodioximetanfetamina (MDMA), um composto sintético com propriedades estimulante central e alucinogênicas. Algumas substâncias análogas à MDMA, já identificadas em comprimidos de ecstasy, são principalmente: 3,4-metilenodioxietilanfetamina (MDEA), 3,4-metilenodioxianfetamina (MDA), metanfetamina e anfetamina. Os a
Publicado em: 2004
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28. Determination of 3,4-methylenedioxymethamphetamine (MDMA - Ecstasy), 3,4-methylenedioxyethylamphetamine (MDEA - Eve) and 3,4-methylenedioxyamphetamine (MDA) in biological fluids by high-performance liquid chromatography: forensic aspect / Determinação de 3,4-metilenodioximetanfetamina (MDMA - Ecstasy), 3,4-metilenodioxietilanfetamina (MDEA - Eve) e 3,4-metilenodioxianfetamina (MDA) em fluidos biológicos por cromatografia líquida de alta eficiência: aspecto forense
There is a worldwide increase in the use of the synthetic drugs of abuse known as designer drugs. The main representatives of this class are Ecstasy or 3,4-methylenodioxymethamphetamine (MDMA) and Eve or 3,4- methylenodioxyethylamphetamine (MDEA), substances with stimulant and hallucinogenic effects. In Brazil media coverage of them is on the increase and th
Publicado em: 2004
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29. Ecstasy (MDMA): efeitos e padrões de uso relatados por usuários de São Paulo
OBJETIVO: Não havendo estudos sobre o uso de êxtase no Brasil, o objetivo foi identificar efeitos e padrões de consumo dessa substância entre usuários da cidade de São Paulo. MÉTODOS: A amostra foi recrutada através da técnica de snowball. Foram pesquisados 52 indivíduos de ambos os sexos que vinham utilizando êxtase freqüente e recentemente. Foi
Revista Brasileira de Psiquiatria. Publicado em: 2003-03
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30. Ecstasy users in São Paulo, Brazil : first profile / Primeiro perfil do usuário de "êxtase" (MDMA) em São Paulo
O presente estudo teve como objetivo identificar os padrões de uso de "êxtase" na cidade de São Paulo. Os usuários foram recrutados através da técnica de amostragem snowball, também utilizada para o recrutamento do grupo controle, composto de indivíduos com estilo de vida semelhante aos primeiros mas que nunca haviam experimentado "êxtase" (não usu
Publicado em: 2000
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31. Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine and Its Enantiomers in Mice: Pharmacokinetic Considerations
3,4-Methylenedioxymethamphetamine (MDMA) is a drug of abuse with mixed stimulant- and hallucinogen-like effects. The aims of the present studies were to establish discrimination of S(+)-MDMA, R(-)-MDMA, or their combination as racemic MDMA in separate groups of mice to assess cross-substitution tests among all three compounds, to determine the time cour
American Society for Pharmacology and Experimental Therapeutics.
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32. Effects of Dose and Route of Administration on Pharmacokinetics of (±)-3,4-Methylenedioxymethamphetamine in the Rat
Based on animal data, there is speculation that (±)-3,4-methylenedioxymethamphetamine (MDMA) is neurotoxic to humans. Extrapolation of MDMA findings from animals to humans requires assessment of pharmacokinetics in various species, and low-dose administration data from rats are lacking. In this study, we examine MDMA pharmacokinetics in rats given low (2 mg
The American Society for Pharmacology and Experimental Therapeutics.
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33. Discriminative Stimulus Effects of Psychostimulants and Hallucinogens in S(+)-3,4-Methylenedioxymethamphetamine (MDMA) and R(−)-MDMA Trained Mice
3,4-Methylenedioxymethamphetamine (MDMA) is a substituted phenethylamine more commonly known as the drug of abuse “ecstasy.” The acute and persistent neurochemical effects of MDMA in the mice are distinct from those in other species. MDMA shares biological effects with both amphetamine-type stimulants and mescaline-type hallucinogens, which may be attrib
The American Society for Pharmacology and Experimental Therapeutics.
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34. The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release.
MDMA ("ecstasy") has been widely reported as a drug of abuse and as a neurotoxin. This report describes the mechanism of MDMA action at serotonin transporters from plasma membranes and secretory vesicles. MDMA stimulates serotonin efflux from both types of membrane vesicle. In plasma membrane vesicles isolated from human platelets, MDMA inhibits serotonin tr
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35. Further Studies on the Role of Metabolites in (±)-3,4-Methylenedioxymethamphetamine-Induced Serotonergic Neurotoxicity
The mechanism by which the recreational drug (±)-3,4-methylenedioxymethamphetamine (MDMA) destroys brain serotonin (5-HT) axon terminals is not understood. Recent studies have implicated MDMA metabolites, but their precise role remains unclear. To further evaluate the relative importance of metabolites versus the parent compound in neurotoxicity, we explore
The American Society for Pharmacology and Experimental Therapeutics.
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36. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy IngestionS⃞
3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) is a widely misused synthetic amphetamine derivative and a serotonergic neurotoxicant in animal models and possibly humans. The underlying mechanism of neurotoxicity involves the formation of reactive oxygen species although their source remains unclear. It has been postulated that MDMA-induced neurotoxic
American Society for Pharmacology and Experimental Therapeutics.