Major Histocompatibility Complex
Mostrando 13-24 de 2435 artigos, teses e dissertações.
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13. Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development
CD8+ T cells against malaria liver stages represent a major protective immune mechanism against infection. Following induction in the peripheral lymph nodes by dendritic cells (DCs), these CD8+ T cells migrate to the liver and eliminate parasite infected hepatocytes. The processing and presentation of sporozoite antigen requires TAP mediated transport of maj
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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14. The role of natural killer cells in chronic myeloid leukemia
Chronic myeloid leukemia is a neoplasia resulting from a translocation between chromosomes 9 and 22 producing the BCR-ABL hybrid known as the Philadelphia chromosome (Ph). In chronic myeloid leukemia a proliferation of malignant myeloid cells occurs in the bone marrow due to excessive tyrosine kinase activity. In order to maintain homeostasis, natural killer
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-06
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15. Freqüências de alelos e haplótipos HLA A, -B e DRB1 em uma amostra de doadores voluntários de medula óssea do estado do Rio Grande do Sul
As moléculas HLA (Human Leucocyte Antigens) são proteínas codificadas por genes altamente polimórficos localizados na região do MHC (Major Histocompatibility Complex) no braço curto do cromossomo 6 humano. Elas estão envolvidas em processos de resposta imunológica, sendo responsáveis pela apresentação de antígenos aos linfócitos T. O sistema HLA
Publicado em: 2011
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16. Immunomodulatory effect of mesenchymal stem cells
Mesenchymal stem cells (MSC) are multipotential nonhematopoietic progenitor cells capable of differentiating into multiple mesenchymal tissues. MSC are able to reconstitute the functional human hematopoietic microenvironment and promote engraftment of hematopoietic stem cells. MSC constitutively express low levels of major histocompatibility complex-I molecu
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-05
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17. Heterotopic transplantation of glycerin-preserved trachea : effect of respiratory epithelium desquamation on acute rejection
An effective preservation method and decreased rejection are essential for tracheal transplantation in the reconstruction of large airway defects. Our objective in the present study was to evaluate the antigenic properties of glycerin-preserved tracheal segments. Sixty-one tracheal segments (2.4 to 3.1 cm) were divided into three groups: autograft (N = 21),
Publicado em: 2010
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18. HLA-DRB1 alleles in four Amerindian populations from Argentina and Paraguay
The major histocompatibility complex (MHC) is one of the biological systems of major polymorphisms. The study of HLA class II variability has allowed the identification of several alleles that are characteristic to Amerindian populations, and it is an excellent tool to define the relations and biological affinities among them. In this work, we analyzed the a
Genetics and Molecular Biology. Publicado em: 2009
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19. Influence of Glatiramer acetate on the synaptic stability and glial reaction during the EAE and after motor root avulsion / Influencia do acetato de glatiramer (AG) sobre a estabilidade sinaptica e reação glial durante o curso da EAE e apos avulsão de raizes motoras
Multiple sclerosis (MS) is an inflammatory and demyelinating disease, which etiology is unknown. Although it is the result of a major autoimmune response. The Glatiramer acetate (GA) is a drug used to treat MS and is composed by four peptides homologous to the myelin basic protein (MBP), that is able to reduce the exacerbation and injuries to the CNS. Nevert
Publicado em: 2009
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20. Polimorfismos dos genes HLA e regiões promotoras do TNF- alfa -238 e -308 como fatores de sucetibilidade a psoriase e gravidade da doença / HLA and TNF-Alpha promoter regions -238 and -308 polymorphisms and marks of susceptibility to psoriasis and severety of the disease
Psoriasis is an erythematous, scaly inflammatory dermatosis with a complex immunologic basis. The strongest genetic marker for psoriasis is HLA-Cw*06. Polymorphisms in the TNF-a promoter region, especially replacement of guanine with adenine in positions -238 and -308 are related to higher TNF-a production and higher risk for psoriasis in Caucasoid populatio
Publicado em: 2009
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21. Polymorphism of locus DRB3.2 in populations of Creole Cattle from Northern Mexico
The polymorphism of locus BoLA-DRB3.2 of the Major Histocompatibility Complex was evaluated in two northern Mexican Creole cattle populations, Chihuahua (n = 47) and Tamaulipas (n = 51). The BoLA-DRB3.2 locus was typed by amplification and digestion with restriction endonuclease enzymes (PCR-RFLP). Fifty-two alleles were detected (28 previously reported and
Genetics and Molecular Biology. Publicado em: 19/11/2008
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22. Estudo do poliformismo genético na hepatite auto-imune na infância: busca de genes e haplótipos de suscetibilidade / Study of genetic polymorphism in children: searching for susceptibility genes and haplotypes
A hepatite auto-imune (HAI) é uma doença inflamatória crônica do fígado, de etiologia desconhecida, que acomete preferencialmente mulheres, com destruição progressiva do parênquima hepático e que, sem tratamento imunossupressor, evolui freqüentemente para cirrose. É uma doença rara na infância, com menos de 10% dos pacientes com doença hepátic
Publicado em: 2008
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23. Contribution of CD4+ T cells to the early mechanisms of ischemia- reperfusion injury in a mouse model of acute renal failure
Renal ischemia-reperfusion (IR) injury is the major cause of acute renal failure in native and transplanted kidneys. Mononuclear leukocytes have been reported in renal tissue as part of the innate and adaptive responses triggered by IR. We investigated the participation of CD4+ T lymphocytes in the pathogenesis of renal IR injury. Male mice (C57BL/6, 8 to 12
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-04
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24. Polymorphism of exon 2-3 of bovine major histocompatibility complex class I BoLa-A gene
The exon 2-3 region of bovine major histocompatibility complex (MHC) class I BoLa-A gene was investigated for polymorphisms in three breeds of cattle originated in the Indian subcontinent namely Sahiwal, Tharparkar, Hariana, as well as crossbred (Bos taurus x Bos indicus) cattle and Jersey, the exotic breed (Bos taurus). The PCR amplified fragment of 714 bp
Genetics and Molecular Biology. Publicado em: 2007