Macrocyclic Trichothecenes
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. INTOXICAÇÃO EM BÚFALOS (Bubalus bubalis) POR Baccharis megapotamica var. weirii / Poisoning in water buffalo (Bubalus bubalis) by Baccharis megapotamica var. weirii
Na primeira parte dessa tese, relatamos a ocorrência natural de um surto de intoxicação por Baccharis megapotamica var. weirii em búfalos na Região Central do Rio Grande do Sul. Os animais haviam sido transportados de uma propriedade onde a planta não ocorria para uma propriedade infestada pela planta. Durante o transporte, os animais foram submetidos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/03/2012
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2. 7 alpha-hydroxytrichodermol, a new trichothecene from Myrothecium roridum.
Five plant-pathogenic isolates of Myrothecium roridum from Florida produced only simple trichothecenes rather than the usual macrocyclic trichothecenes. The major metabolite was 7 alpha-hydroxytrichodermol.
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3. Macrocyclic trichothecene toxins produced by Stachybotrys atra strains isolated in Middle Europe.
A total of 17 strains of Stachybotrys atra isolated in Hungary and Czechoslovakia were cultured on Sabouraud agar, and the toxins produced by them were chemically analyzed by gas-liquid chromatography, high-pressure liquid chromatography, and mass spectroscopy. Furthermore, brine shrimp (Artemia salina) bioassay was used for the determination of toxicity of
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4. Stachybotrys atra Growth and Toxin Production in Some Building Materials and Fodder under Different Relative Humidities
Growth of Stachybotrys atra and its toxin production on some building materials and in animal fodder were studied at relative humidities ranging from 78 to 100%. Toxins were detected by biological assays and chemical methods. Strong growth of the fungus and presence of macrocyclic trichothecenes, mainly satratoxins G and H, were detected on wallpaper and gyp
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5. Trichothecenes produced by Stachybotrys atra from Eastern Europe.
A total of 17 isolates of Stachybotrys atra isolated from various parts of Hungary and Czechoslovakia were grown on rice, and the toxin production of each isolate was analyzed by high-performance liquid chromatography. Of the 17 isolates, 14 produced macrocyclic trichothecenes (satratoxins F, G, and H, roridin E, and verrucarin J) as well as trichoverrols A
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6. Detection of Airborne Stachybotrys chartarum Macrocyclic Trichothecene Mycotoxins on Particulates Smaller than Conidia
Highly respirable particles (diameter, <1 μm) constitute the majority of particulate matter found in indoor air. It is hypothesized that these particles serve as carriers for toxic compounds, specifically the compounds produced by molds in water-damaged buildings. The presence of airborne Stachybotrys chartarum trichothecene mycotoxins on particles smaller
American Society for Microbiology.
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7. Mycotoxin production by Fusarium oxysporum and Fusarium sporotrichioides isolated from Baccharis spp. from Brazil.
Fusarium oxysporum isolated from roots of and soil around Baccharis species from Brazil produced the trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol, and 3'-OH T-2 (TC-1), whereas Fusarium sporotrichioides from the same source produced T-2 toxin, HT-2 toxin, acetyl T-2, neosolaniol, TC-1, 3'-OH HT-2 (TC-3), iso-T-2, T-2 triol, T-2 tetraol, and the n
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8. Enzyme immunoassay for the macrocyclic trichothecene roridin A: production, properties, and use of rabbit antibodies.
Antisera against roridin A were prepared by using a roridin A-hemisuccinate derivative coupled to human serum albumin as the immunogen. Antibodies could be detected in the sera of the immunized rabbits as early as 4 weeks after the initial exposure. After one booster injection at week 14, high antibody titers were measured over a period of 21 weeks. The spec
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9. Microbial Transformation of Macrocyclic Trichothecenes
A resting culture of Rhizopus arrhizus (ATCC 11145) transformed verrucarin A into 16-hydroxyverrucarin A, whereas R. arrhizus transformed verrucarin B into a mixture of 16-hydroxyverrucarin B and 3′-hydroxyverrucarin A. Relative to verrucarins A and B, the 16-hydroxy derivatives showed marked increases in activity, as tested in vivo against P388 mouse leuk
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10. Production and characterization of monoclonal antibodies to the macrocyclic trichothecene roridin A.
Two murine monoclonal antibodies to the macrocyclic trichothecene roridin A are described. Screening for antibody production was performed on absorbed anti-mouse immunoglobulin serum as double-antibody solid phase, and further characterization was done on affinity-purified anti-mouse IgG serum. The antibodies, designated 5G11 and 4H10, had affinity constants
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11. Production and characterization of antibody against deoxyverrucarol.
Immunization of rabbits with deoxyverrucarol (DOVE) conjugated to bovine serum albumin resulted in antibodies bound with either tritiated DOVE or diacetoxyscirpenol (DAS), but not with T-2 toxin. The affinity of antibodies with DOVE was found to be much higher than with DAS. When [3H] DOVE was used as a marking ligand in the competitive radioimmunoassay, the