Mostrando 1-12 de 41 artigos, teses e dissertações.
1. Genetic susceptibility in leprosy: molecular analysis of HLA classroom II and classroom III. / Suscetibilidade Genética na Hanseníase:análise Molecular de HLA classe II &classe III.
Diversos estudos têm demonstrado a influência da variabilidade genética humana na capacidade de resposta ao M. leprae, agente etiológico causador da hanseníase. Através de diferentes técnicas a genética moderna tem contribuído para a determinação de regiões importantes associadas à doença, dentre elas o cromossomo 6p21, apontando principalmente
Publicado em: 2007
2. Polymorphism in lymphotoxin-alpha gene is associated with susceptibility to periodontal disease / Analise do polimorfismo genetico do fator de necrose tumoral Beta (+252 A/G) em pacientes com periodontite cronica
A doença periodontal (DP) é causada por interações entre fatores do hospedeiro, microrganismos específicos patogênicos e o sistema imunológico. TNF-b é um imunoregulador multifuncional que está relacionado com a patogênese de diversas desordens imunológicas, incluindo a DP. Nosso estudo analisou a associação entre DP e polimorfismo no gene TNF-b
Publicado em: 2005
3. Purification and characterization of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients.
Serum ultrafiltrates (SUF) from human patients with different types of cancer contain a blocking factor (BF) that inhibits the cytolytic activity of human tumor necrosis factor alpha (TNF-alpha) in vitro. BF is a protein with a molecular mass of 28 kDa on reducing sodium dodecyl sulfate/polyacrylamide gel electrophoresis (SDS/PAGE). The active material was p
4. Lymphotoxin Inhibits Chlamydia pneumoniae Growth in HEp-2 Cells
Cytokines such as gamma interferon and tumor necrosis factor alpha (TNF-α) inhibit the intracellular replication of Chlamydia pneumoniae or Chlamydia trachomatis. In this study, we found that another cytokine, lymphotoxin (TNF-β), restricts the growth of C. pneumoniae in HEp-2 cells. When lymphotoxin (10 U/ml) was added during incubation from 8 to 16 h pos
American Society for Microbiology.
5. Role of lymphotoxin in expression of interleukin 6 in human fibroblasts. Stimulation and regulation.
IL-6 is a cytokine with a number of biological functions, including stimulation of immunoglobulin synthesis and proliferation of early hematopoietic stem cells. We showed that lymphotoxin stimulated accumulation of IL-6 mRNA in human fibroblasts (W138) in a dose-responsive fashion; tumor necrosis factor-alpha (TNF-alpha) was about threefold more potent than
6. Nucleotide sequence of the murine TNF locus, including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes.
7. The genes for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) are tandemly arranged on chromosome 17 of the mouse.
We have isolated clones containing the gene for tumor necrosis factor (TNF-alpha) from a mouse genomic library. Four out of five clones containing the TNF-alpha gene also hybridized to a human lymphotoxin (TNF-beta) probe. We constructed a restriction enzyme cleavage map of a 6.4 kb region from one of the genomic clones. From partial sequencing data and hybr
8. Tumor necrosis factor and lymphotoxin-alpha genetic polymorphisms and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study of patients treated with BFM therapy
9. Cloning and expression analysis of the murine lymphotoxin beta gene.
Tumor necrosis factor alpha (TNF-alpha) and soluble lymphotoxin (LT) (also called LT-alpha or TNF-beta) are cytokines with similar biological activities that are encoded by related and closely linked genes. TNF-alpha, a mediator of the inflammatory response, exists in soluble and transmembrane forms. LT-alpha can be secreted or retained at the cell surface b
10. Induction of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by Pseudomonas aeruginosa and exotoxin A-induced suppression of lymphoproliferation and TNF, lymphotoxin, gamma interferon, and IL-1 production in human leukocytes.
Pseudomonas aeruginosa is a dominant pathogen in infection in cystic fibrosis. This bacterium is thought to play a major role in the chronic bronchial infection-induced pathophysiology. Our data showed that whole formalin-fixed heat-killed P. aeruginosa was mitogenic for human lymphocytes and induced production of substantial amounts of tumor necrosis factor
11. Constitutive expression of a 92-kD gelatinase (type V collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines.
Synovial fibroblasts freshly isolated from the rheumatoid joint are characterized by their marked connective tissue degradative ability. This phenotype includes the ability to secrete large amounts of the matrix-degrading metalloproteinases, collagenase, and stromelysin. We have found that another aspect of this phenotype is the constitutive expression at bo
12. Analysis of Cytokines in the Early Development of Gastric Secondary Lymphoid Follicles in Helicobacter pylori-Infected BALB/c Mice with Neonatal Thymectomy
Immunological interaction between the host and Helicobacter pylori seems to play a critical role in follicular formation in gastric mucosa. We reported H. pylori-induced follicular gastritis model using neonatally thymectomized mice. In this study, we investigated the involvement of various cytokines in this model. BALB/c mice were thymectomized on the third
American Society for Microbiology.