Liver Cirrhosis Experimental
Mostrando 1-12 de 25 artigos, teses e dissertações.
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1. Hepatoprotective and antineoplastic potencial of red propolis produced by the bees Apis mellifera in the semiarid of Rio Grande do Norte, Brazil
RESUMO: Este estudo objetivou avaliar o efeito hepatoprotetor do extrato etanólico da própolis vermelha da abelha Apis mellifera, obtido em quatro municípios do semiárido do Rio Grande do Norte, mediante avaliação in vitro do potencial antineoplásico em linhagens de células de carcinoma hepático humano (HepG2) e em linhagens de células normais (L92
Pesq. Vet. Bras.. Publicado em: 04/11/2019
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2. Diabetes mellitus triggers oxidative stress in the liver of alloxan-treated rats: a mechanism for diabetic chronic liver disease
PURPOSE: To investigate whether Diabetes mellitus chemically induced by alloxan is capable of changing, in the long term, the oxidative balance in the liver tissue of rats. METHODS: Sixty male Wistar rats, weighing 250-280g, were randomly distributed into two experimental groups: NG - 30 non-diabetic control rats; DG - 30 alloxan- induced diabetic rats witho
Acta Cir. Bras.. Publicado em: 2013-07
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3. FUNCTIONAL PROTEOMICS OF CIRRHOSIS AND HEPATOCELLULAR CARCINOMA / ProteÃmica Funcional da Cirrose e do Carcinoma Hepatocelular
Introduction. Cancer is the most common given name to a series of molecular and physiological events which result in genetic instability and biochemical imbalance in cells. Among the seven events that drives cell cancer, the role of chronic inflammation and tumor microenvironment in cancer development were highlighted in this work . To experimentally evaluat
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/03/2012
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4. Efeito da hepatectomia parcial associada à administração de fatores nutricionais hepatotróficos sobre a morfologia, função e expressão de genes pró-fibróticos na cirrose hepática em ratos Wistar induzida por tiocetamida / Effects of partial hepatectomy associated with administration of nutritional hepatotrophic factors in morphology, function and expression of pro-fibrotic genes in thioacetamide-induced liver cirrhosis in Wistar rats
The current study evaluated the role of parenteral solution of nutritional hepatotrophic factors in animals with cirrhosis undergoing partial hepatectomy. This procedure is fearful in these animals due to the possibility of acute liver failure, since removal of a liver fragment further reduces the functional capacity of an already compromised organ. Moreover
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2011
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5. An ultrasound and histomorphological analysis of experimental liver cirrhosis in rats
We investigated whether liver injury by dual exposure to ethanol and carbon tetrachloride (EtOH + CCl4) for 15 weeks would persist after hepatotoxic agents were removed (EtOH + CCl4/8wR). After 15 weeks of hepatic injury with ethanol (5.5%, m/v) and carbon tetrachloride (0.05, mL/kg, ip), 5 of 11 female Wistar rats were sacrificed. The other 6 rats were main
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-11
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6. Oxidized low-density-lipoprotein accumulation is associated with liver fibrosis in experimental cholestasis
OBJECTIVE: The aim of the present study was to examine the probable relationship between the accumulation of oxLDL and hepatic fibrogenesis in cholestatic rats. INTRODUCTION: There is growing evidence to support the current theories on how oxidative stress that results in lipid peroxidation is involved in the pathogenesis of cholestatic liver injury and fibr
Clinics. Publicado em: 2008
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7. Hepatic cirrhosis induced by thioacetamide: study of the model of intraperitoneal long term administration in Wistar rats / Cirrose hepática induzida por tioacetamida: estudo do modelo por injeção intraperitonial a longo prazo em ratas Wistar
A baixa sensibilidade dos animais à droga e a função hepática pouco alterada são as principais dificuldades para o desenvolvimento da cirrose hepática experimental. A proposta deste trabalho foi aprimorar o modelo de cirrose por injeção intraperitoneal de tioacetamida (TAA) a fim de reduzir a adaptação dos animais ao fármaco. Foram utilizados 5 gr
Publicado em: 2008
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8. Male gonadal function, prolactin secretion and lactotroph population in an experimental model of cirrhosis
Liver cirrhosis, a highly prevalent chronic disease, is frequently associated with endocrine dysfunctions, notably in the gonadal axis. We evaluated lactotroph population by immunohistochemistry, gonadotropins and prolactin by immunoradiometric assay and testosterone and estradiol by radioimmunoassay in adult male Wistar rats with cirrhosis induced by carbon
Brazilian Journal of Medical and Biological Research. Publicado em: 31/07/2007
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9. Esteato-hepatite não alcoólica (ENA) em camundongos obesos (ob/ob): avaliação do efeito citoprotetor do Yo Jyo Hen Shi Ko (YHK) / YO JYO HEN SHI KO, a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine/choline deficient diet
Background: Oxidative stress plays a role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Yo Jyo Hen Shi Ko (YHK) is a complex compound purported to reduce reactive oxygen species (ROS) by blocking the propagation of radical-induced reactions. Aim: The aim of this study was to evaluate the role of the effect of YHK in experimental NASH. Methods:
Publicado em: 2007
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10. Esteatose hepática em ratos: efeitos de dieta com diferentes níveis de substituição lipídica por dieptanoína e trieptanoína.
Hepatic steatosis is characterised by accumulation of triacylglycerols in the cytoplasm of hepatocytes at a level that reaches 5 to 40% of the weight of the liver. Its prevalence has increased worldwide, having a strong relationship with diabetes mellitus type 2 and obesity, diseases that constitute a global epidemic. Despite having been considered for a con
Publicado em: 2007
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11. Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model
Interferon-alpha is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits fibrogenesis. Rats infected with the helminth Capillaria hepatica regularly develop diffuse septal fibrosis of the l
Memórias do Instituto Oswaldo Cruz. Publicado em: 2001-04
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12. Hepatic capillariasis in rats: a new model for testing antifibrotic drugs
Rats infected with the helminth Capillaria hepatica regularly develop septal hepatic fibrosis that may progress to cirrhosis in a relatively short time. Because of such characteristics, this experimental model was selected for testing drugs exhibiting antifibrosis potential, such as pentoxifylline, gadolinium chloride and vitamin A. Hepatic fibrosis was qual
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-11