Lipoproteins Ldl Drug Effects
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Efeitos da quimioterapia neoadjuvante sobre os receptores de lipoproteínas no tecido tumoral em pacientes com carcinoma da mama localmente avançado / Effects of neoadjuvant chemotherapy on lipoprotein receptors in tumor tissues of patients with locally advanced breast cancer
Proliferative tumor cells present a high expression of LDL receptors due to accelerated mitosis rates which takes to increased need of lipids internalization for building new membranes. Upregulation of LDL receptors may be used as a gate to deliver anticancer drugs to tumor tissues using lipoproteins or artificial nanoemulsions as vehicle. This study investi
Publicado em: 2010
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2. Efeitos pleiotrópicos com reduções equivalentes do LDL-colesterol: estudo comparativo entre sinvastatina e associação sinvastatina/azetimiba / Pleiotropic effects with equivalent LDL-cholesterol reduction: comparative study between simvastatin and simvastatin/ezetimibe coadministration
Introdução: A associação de uma estatina com ezetimiba é tão eficaz quanto altas doses da mesma estatina na redução do LDL-colesterol. Os efeitos que não dependem dessa redução são chamados de pleiotrópicos, entre os quais podemos citar: melhora da função endotelial, efeitos anti-oxidantes, efeitos anti- inflamatórios, entre outros. Objetivo:
Publicado em: 2007
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3. Consequences of Interaction of a Lipophilic Endotoxin Antagonist with Plasma Lipoproteins
E5531, a novel synthetic lipid A analogue, antagonizes the toxic effects of lipopolysaccharide, making it a potential intravenously administered therapeutic agent for the treatment of sepsis. This report describes the distribution of E5531 in human blood and its activity when it is associated with different lipoprotein subclasses. After in vitro incubation o
American Society for Microbiology.
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4. Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification.
Several lines of evidence indicate that the oxidative modification of low density lipoproteins (LDL) may provide an important link between plasma LDL and the genesis of the atherosclerotic lesion. Ascorbate is an important water-soluble, chain-breaking antioxidant in humans. Probucol, a lipid-soluble antioxidant drug has been shown to retard the progression