Lipolysis And Fat Diet
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver
Our previous study has shown that reduced insulin resistance (IR) was one of the possible mechanisms for the therapeutic effect of silibinin on non-alcoholic fatty liver disease (NAFLD) in rats. In the present study, we investigated the pathways of silibinin in regulating hepatic glucose production and IR amelioration. Forty-five 4- to 6-week-old male Spragu
Braz J Med Biol Res. Publicado em: 15/03/2013
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2. A influência da flora intestinal e da esplenectomia na resistência à insulina induzida por obesidade / Influence of gut microbiota and splenectomy over the obesity-induced insulin resistance
A high-fat diet intake induces obesity and chronic subclinical inflammation, which play important roles in insulin resistance. Increased circulating levels of proinflammatory cytokines, free fatty acids and lipopolysaccharides activate innate immune system, which triggers inflammation and cytokine expression, leading to insulin resistance. Thus, we investiga
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/03/2012
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3. Efeitos do extrato de chá verde sobre marcadores inflamatórios e lipolíticos no tecido adiposo de camundongos / Effects of green tea extract on inflammatory and lipolytic markers in adipose tissue of mice
Objetivo: Analisar os efeitos do extrato de cha verde sobre a producao de citocinas pro e anti-inflamatorias (TNF-, IL-6, IL-10 e adiponectina) no tecido adiposo mesenterico, assim como, analise proteica da via de sinalizacao inflamatoria TLR-4, MyD88, TRAF6 e lipolitica . Analisar a expressao proteica das estruturas envolvidas na lipolise ATGL, ABHD5(CGI-58
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2011
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4. Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism.
The chronic and acute effects of different types of dietary fat on postprandial lipoprotein metabolism were studied in eight normolipidemic subjects. Each person was placed for 25 d on each of three isocaloric diets: a saturated fat (SFA), a w-6 polyunsaturated fat (w-6 PUFA) and a w-3 polyunsaturated fat (w-3 PUFA) diet. Two vitamin A-fat loading tests were
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5. Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice
Acc2-/- mutant mice, when fed a high-fat/high-carbohydrate (HF/HC) diet, were protected against diet-induced obesity and diabetes. To investigate the role of acetyl-CoA carboxylase 2 (ACC2) in the regulation of energy metabolism in adipose tissues, we studied fatty acid and glucose oxidation in primary cultures of adipocytes isolated from wild-type and Acc2-
National Academy of Sciences.
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6. Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection.
Short-term alterations in dietary carbohydrate (CHO) energy are known to alter whole-body fuel selection in humans, but the metabolic mechanisms remain unknown. We used stable isotope-mass spectrometric methods with indirect calorimetry in normal subjects to quantify the metabolic response to six dietary phases (5 d each), ranging from 50% surplus CHO (+50%
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7. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
Perilipin coats the lipid droplets of adipocytes and is thought to have a role in regulating triacylglycerol hydrolysis. To study the role of perilipin in vivo, we have created a perilipin knockout mouse. Perilipin null (peri−/−) and wild-type (peri+/+) mice consume equal amounts of food, but the adipose tissue mass in the null animals is reduced t
The National Academy of Sciences.
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8. Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance
Low-fat, high-carbohydrate (LF/HC) diets commonly elevate plasma triglyceride (TG) concentrations, but the kinetic mechanisms responsible for this effect remain uncertain. Subjects with low TG (normolipidemic [NL]) and those with moderately elevated TG (hypertriglyceridemic [HTG]) were studied on both a control and an LF/HC diet. We measured VLDL particle an
American Society for Clinical Investigation.
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9. Skin-specific Deletion of Stearoyl-CoA Desaturase-1 Alters Skin Lipid Composition and Protects Mice from High Fat Diet-induced Obesity*
Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids and is an important regulator of whole body energy homeostasis. Severe cutaneous changes in mice globally deficient in SCD1 also indicate a role for SCD1 in maintaining skin lipids. We have generated mice with a skin-specific deletion of SCD1 (SKO) and report here that SK
American Society for Biochemistry and Molecular Biology.
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10. Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G)
Phenolic acids are found in abundance throughout the plant kingdom. Consumption of wine or other rich sources of phenolic acids, such as the “Mediterranean diet,” has been associated with a lower risk of cardiovascular disease. The underlying mechanism(s), however, has remained unclear. Here, we show that many phenolic acids, including those from the hyd
American Society for Biochemistry and Molecular Biology.
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11. Effect of Low-Roughage Diets on the Microflora and Lipid Metabolism in the Rumen
Changing the diet of five lactating cows and one nonlactating cow from high to low roughage induced milk fat depression in the lactating cows and altered the composition of the rumen microflora. While the numbers of lactic and propionic acid-producing bacteria increased, the numbers of Butyrivibrio spp. decreased. The numbers of lipolytic bacteria and the in
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12. Mechanisms of nutritional and hormonal regulation of lipogenesis
Fat build-up is determined by the balance between lipogenesis and lipolysis/fatty acid oxidation. In the past few years, our understanding of the nutritional, hormonal and particularly transcriptional regulation of lipogenesis has expanded greatly. Lipogenesis is stimulated by a high carbohydrate diet, whereas it is inhibited by polyunsaturated fatty acids a
Oxford University Press.