Lipolysaccharide
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Avaliação da qualidade e potencial atividade adjuvante do lipídio A de Bordetella pertussis. / Quality assessment and potential adjuvant activity of Bordetella pertussis lipid A.
Atualmente várias substâncias estão sendo avaliadas quanto à sua possível atividade adjuvante, apresentando alta potência, mas também alta toxicidade, que os impede de serem introduzidos numa rotina clínica, como o lipopolissacarídio (LPS), componente da parede celular das bactérias Gram negativas. Estudos têm estimulado o desenvolvimento de deriv
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/06/2011
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2. Nasal immunization with outer membrane antigens of Neisseria meningitidis B selected for the highest expression of the immunotype of LPS 3,7,9 with monoclonal antibodies and Bordetella pertussis as adjuvants in neonates mice. / Imunização nasal com antígenos de membrana externa de Neisseria meningitidis B selecionados para a maior expressão do imunotipo de LPS 3, 7, 9 com anticorpos monoclonais e Bordetella pertussis como adjuvante em camundongos neonatos.
The natural habitat of Neisseria meningitidis is the human nasopharynx, and the bacterium is transmitted by direct mouth-to-mouth contact or by the inhalation of released mucous particles during close contact. N meningitidis is a Gram-negative bacterium responsible for significant mortality worldwide. While effective polysaccharide-based vaccines exist again
Publicado em: 2008
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3. Thiobarbiturate-reacting Materials in Microorganisms1
The amount of thiobarbiturate-reacting material in 51 strains of bacteria and three yeasts was determined. Reactive material was found to be present in all of the gram-negative bacteria examined. It was assumed that the reactive material in this case was primarily 2-keto-3-deoxyoctonate (KDO), an eight-carbon sugar acid which is usually associated with the c
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4. Augmented immunological activities of recombinant lipopolysaccharide possessing the mannose homopolymer as the O-specific polysaccharide.
Recombinant lipopolysaccharide possessing the mannose homopolymer as the O-specific polysaccharide was manufactured genetically by transforming Escherichia coli K-12 with various rfb genes capable of synthesizing the mannose homopolymer. Recombinant lipopolysaccharide exhibited levels of anticomplement activity, adjuvant activity, and regional lymph node-enl
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5. Gastrointestinal antibody responses in axenic mice to topically administered Escherichia coli.
Immunoglobulin levels were determined in gastrointestinal secretions of both conventional and axenic mice, as was the stability of the immunoglobulin classes in these secretions. Axenic animals were then administered nonviable Escherichia coli O111:B4 by topical application into the oral cavity. Immunoglobulin (Ig) A, IgG1, AND IgG2 were detected in the gast
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6. Comparative efficacy and toxicity of a ribosomal vaccine, acetone-killed cells, lipopolysaccharide, and a live cell vaccine prepared from Salmonella typhhimurium.
The protective and toxic properties of a ribosomal vaccine prepared from Salmonella typhimurium W118-2 were systematicaly compared with those of an acetone-killed whole cell vaccine, purified lipopolysaccharide, and living cells in CD-1 mice. Tests of graded immunizing doses of each vaccine against several challenge doses of live strain W118-2 showed that, a
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7. Stimulation of the ceramide pathway partially mimics lipopolysaccharide-induced responses in murine peritoneal macrophages.
Recent studies have suggested that lipolysaccharide (LPS) stimulates cells by mimicking the second-messenger function of ceramide, a lipid generated in the cell by the action of sphingomyelinase (SMase). To examine this possibility further, we compared the abilities of LPS, SMase, and/or ceramide analogs to induce cytokine secretion, modulate gene expression
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8. Comparative studies of lipopolysaccharide and exopolysaccharide from a virulent strain of Pseudomonas solanacearum and from three avirulent mutants.
The composition of the Pseudomonas solanacearum lipolysaccharide (LPS) was found to be similar to that described for the LPS of enterobacteria. The lipid A contained fatty acids and glucosamine in a molar ratio of 5:2. The LPS fraction contained 2-keto-3-deoxyoctulosonic acid, L-glycero-D-mannoheptose, hexoses (glucose, rhamnose, and glucosamine), and a pent