Lipoic Acid
Mostrando 13-24 de 84 artigos, teses e dissertações.
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13. Functional characterization of a new antioxidant protein: Ohr (Organic Hydroperoxide Resistance Protein). Pathways of reduction and expression in Xylella fastidiosa / Caracterização funcional de uma nova proteína antioxidante: Ohr (Organic Hydroperoxide Resistance Protein). Vias de redução e expressão em Xylella fastidiosa
Xylella fastidiosa é uma bactéria gram-negativa, colonizadora do xilema de plantas economicamente importantes, sendo responsável por diversas patogenias como a doença de Pierce em videiras e a clorose variegada dos citros (CVC). Plantas, ao serem infectadas por patógenos, dispõem de um maquinário de defesa que inclui a geração de espécies reativas
Publicado em: 2010
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14. Estabilização do ácido lipoico via encapsulação em nanocápsulas poliméricas planejadas para aplicação cutânea
This work reports the development of polymeric nanocapsules containing lipoic acid prepared by interfacial deposition of poli(ε-caprolactona). The suspensions showed acid pH and encapsulation efficiencies from 77 to 90%. Zeta potential values were from -7.42 to -5.43 mV and particle sizes were lower than 340 nm with polidispersion lower than 0.3. The stabil
Química Nova. Publicado em: 2009
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15. O impacto da intervenção com suplementação de ácido alfa-lipólico e alfa-tocoferol no controle de resistência à insulina e outros componentes da síndrome metabólica em pacientes com diabetes mellitus tipo 2 / The impact of alfa-lipoic acid and alfa-tocopherol supplementation in the control of insulin resistance and other metabolic syndrome components in patients with type 2 diabetes mellitus.
Introduction. Associated with infect-contagious diseases and malnutrition, diabetes mellitus type 2 is admittedly an important problem of Public Health, if limitations affecting individuals´ quality of living and high social costs further to treatments, losses in productivity and shortening of life expectancy are taken into account. One of the characteristi
Publicado em: 2008
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16. Efeito do ácido lipóico sobre parâmetros de estresse oxidativo em indivíduos traço falciformes ou pacientes falciformes / Alpha lipoic acid effect on oxidative stress parameters in sickle cell trait subjects and sickle cell patients
A anemia falciforme (AF) é causada por uma mutação (Glu6Val) no gene que codifica a b-globina gerando a hemoglobina S (HbS). A HbS tem a tendência a se polimerizar quando desoxigenada. Isto resulta em graves manifestações clínicas para o indivíduo homozigoto (HbSS). O traço falciforme (HbAS), geralmente assintomático, também pode apresentar dano o
Publicado em: 2008
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17. Burning mouth syndrome: double-blind placebo-controlled crossover trial of effectiveness of alpha lipoic acid and taste evaluation / Síndrome de ardência bucal: estudo duplo cego cruzado placebo-controlado da efetividade do ácido alfa-lipóico sobre a sintomatologia e avaliação da função gustatória
A síndrome de ardência bucal (SAB) é uma condição crônica, caracterizada por sensação de ardor bucal sem alterações clinicamente detectáveis. Afeta predominantemente mulheres no período pós-menopausa e sua terapêutica ainda não está estabelecida. Pelo menos dois terços destes pacientes apresentam queixa subjetiva de disgeusia como sintoma se
Publicado em: 2008
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18. Effects of dimethylsulfoxide, lipoic acid or ternatin pretreatment upon the oxidative stress in young rats subjected to torsion of the spermatic cord / Efeitos do pré-tratamento com dimetilsufóxido, ácido lipóico ou ternatina sobre o estresse oxidativo
The protective role of dimethylsulfoxide (DMSO), lipoic acid (LA) and ternatin (TN), known free radical scavengers and cell membrane protectants were evaluated in an experimental model of testis ischemia/reperfusion. One hundred and twenty young male Wistar rats, mean weight 172.515g, were randomized in five equal groups (GS - Sham, GC Control, GD Dimethylsu
Publicado em: 2005
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19. Biosynthesis of Lipoic Acid in Arabidopsis: Cloning and Characterization of the cDNA for Lipoic Acid Synthase1
Lipoic acid is a coenzyme that is essential for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. We report here the isolation and characterization of LIP1 cDNA for lipoic acid synthase of Arabidopsis. The Arabidopsis LIP1 cDNA was isolated using an expressed sequence tag homologous to the lipoic acid s
American Society of Plant Physiologists.
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20. Possible involvement of lipoic acid in binding protein-dependent transport systems in Escherichia coli.
We describe the properties of the binding protein dependent-transport of ribose, galactose, and maltose and of the lactose permease, and the phosphoenolpyruvate-glucose phosphotransferase transport systems in a strain of Escherichia coli which is deficient in the synthesis of lipoic acid, a cofactor involved in alpha-keto acid dehydrogenation. Such a strain
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21. Lipoic acid metabolism in Escherichia coli: sequencing and functional characterization of the lipA and lipB genes.
Two genes, lipA and lipB, involved in lipoic acid biosynthesis or metabolism were characterized by DNA sequence analysis. The translational initiation site of the lipA gene was established, and the lipB gene product was identified as a 25-kDa protein. Overproduction of LipA resulted in the formation of inclusion bodies, from which the protein was readily pur
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22. Mutants of Escherichia coli K-12 that are resistant to a selenium analog of lipoic acid identify unknown genes in lipoate metabolism.
Lipoic acid is a disulfide-containing cofactor required for the reactions catalyzed by alpha-ketoacid dehydrogenase enzyme complexes. We report the chemical synthesis and biological properties of lipoic acid analogs in which one or both sulfur atoms were replaced by selenium. Replacement of either the C-6 or the C-8 sulfur atom with selenium results in lipoi
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23. Synthesis and characterization of selenotrisulfide-derivatives of lipoic acid and lipoamide
Thiol-containing compounds, such as glutathione and cysteine, react with selenite under specific conditions to form selenotrisulfides. Previous studies have focused on isolation and characterization of intermolecular selenotrisulfides. This study describes the preparation and characterization of intramolecular selenotrisulfide derivatives of lipoic acid
The National Academy of Sciences.
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24. Role of Pyruvate Metabolism in the Growth of Streptococcus faecalis in the Presence of Propionate
The growth of Streptococcus faecalis is inhibited by propionate, and the inhibition is reversed by lipoic acid or acetate. A study of the role of pyruvate oxidation in S. faecalis showed that propionate inhibited the lipoic acid-dependent aerobic oxidation of pyruvate in resting cells. Pyruvate dehydrogenation with neotetrazolium as a hydrogen acceptor in ce