Lipocalins
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. NGAL urinária em pacientes sem e com lesão renal aguda em unidade de terapia intensiva
Objetivo: Avaliar a eficácia diagnóstica e prognóstica da lipocalina associada à gelatinase neutrofílica urinária em pacientes de unidade de terapia intensiva. Métodos: Estudo do tipo coorte, prospectivo, longitudinal desenvolvido em uma unidade de
Rev. bras. ter. intensiva. Publicado em: 2014-12
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2. A novel lipocalin homologue from the venom gland of Deinagkistrodon acutus similar to mammalian lipocalins
Lipocalins are involved in a variety of functions including retinol transport, cryptic coloration, olfaction, pheromone transport, prostaglandin synthesis, regulation of the immune response and cell homeostatic mediation. A full-length cDNA clone (named d-lipo), isolated from the venom gland cDNA library of Deinagkistrodon acutus, contained an insert of 664
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
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3. Análise proteômica das salivas dos triatomíneos Rhodnuis brethesi, Rhodnius robustus e Panstrongylus megistus, vetores da doença de Chagas
Triatomine bugs acting as vectors of Chagas‟ disease are haematophagous organisms in all of its evolvement phases. Their feeding success is greatly related to their salivary glands content. The presence of a pool of specific proteins allows this insect to access its food by counteracting host haemostatic mechanisms, such as platelet aggregation, clotti
Publicado em: 2009
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4. Proteoma e transcriptoma comparativo das glândulas salivares de barbeiros das espécies de Rhodnius brethesi, Rhodnius robustus e Panstrongylus megistus
Chagas disease caused by the protozoan Trypanosoma cruzi is mostly transmitted by the triatomine bug and causes over 17 million infections in Latin America. More than 140 species of triatomines were described. The Rhodnius gender comprises almost half of the triatomines found in the Amazon Basin, as Rhodnius brethesi and Rhodnius robustus, normally these ins
Publicado em: 2008
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5. Diversidade molecular e funcional de proteínas da saliva de triatoma infestans,um vetor da doença de chagas
Triatoma infestans is one of the most important vectors of Chagas Disease in Latin America, feeding on vertebrate blood in all life stages. Hematophagous insects salivary glands produce potent pharmacological compounds that counteract host hemostasis, including anti-clotting, anti-platelet, and vasodilatory molecules. The saliva of T. infestans mediates hydr
Publicado em: 2007
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6. Purificação e caracterização bioquimica de um fator procoagulante do veneno de Lonomia obliqua / Purification and biochemistry characterization of a procoagulant factor of Lonomia oblique venom
Since 1986 accidents caused by contact with caterpillars of butterflies of the Lonomia obliqua species comes being notified in the South Region of Brazil. The human envenoming for this species results in alterations of the coagulation system, characterizing a disseminated intravascular coagulation, associated to a severe fibrinolytic syndrome. Studies had de
Publicado em: 2006
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7. Structural organization of the gene for prostaglandin D synthase in the rat brain.
A 3-kilobase-pair gene for rat brain prostaglandin D synthase [(5Z,13E)-(15S)-9 alpha,11 alpha-epidoxy-15-hydroxyprosta-5,13- dienoate D-isomerase, EC 5.3.99.2], which belongs to the lipocalin family, was isolated from a rat genomic DNA library by plaque hybridization with the cDNA for the enzyme. The gene contains seven exons, and all the splice donor and a
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8. Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug
Triabin, a 142-residue protein from the saliva of the blood-sucking triatomine bug Triatoma pallidipennis, is a potent and selective thrombin inhibitor. Its stoichiometric complex with bovine α-thrombin was crystallized, and its crystal structure was solved by Patterson search methods and refined at 2.6-Å resolution to an R value of 0.184. The analysis re
The National Academy of Sciences of the USA.
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9. A human axillary odorant is carried by apolipoprotein D.
The characterization of the source of the odor in the human axillary region is not only of commercial interest but is also important biologically because axillary extracts can alter the length and timing of the female menstrual cycle. In males, the most abundant odor component is known to be E-3-methyl-2-hexenoic acid (E-3M2H), which is liberated from nonodo
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10. Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins.
cDNAs for glutathione-independent prostaglandin D synthase were isolated from cDNA libraries of human brain. The longest cDNA insert was 837 base pairs long and contained a coding region of 570 base pairs corresponding to 190 amino acid residues with a calculated Mr of 21,016. Between two cDNA inserts isolated from the two different libraries, nucleotide sub
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11. A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin
The ability of enzymes to distinguish between fatty acyl groups can involve molecular measuring devices termed hydrocarbon rulers, but the molecular basis for acyl-chain recognition in any membrane-bound enzyme remains to be defined. PagP is an outer membrane acyltransferase that helps pathogenic bacteria to evade the host immune response by transferring a p
Nature Publishing Group.
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12. ANI1. A sex pheromone-induced gene in ceratopteris gametophytes and its possible role in sex determination.
Antheridiogen (ACE) is a pheromone that is required for the development of male gametophytes in the homosporous fern Ceratopteris richardii. Subtractive hybridization of cDNAs isolated from ACE-treated and non-ACE-treated gametophytes was used to isolate genes that are induced by the pheromone. The expression of one gene, ANI1 (for antheridiogen induced), wa