Leukotrienes
Mostrando 13-24 de 171 artigos, teses e dissertações.
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13. Role of leukotrienes in phagocytosis via FcgR by alveolar macrophages from healthy and diabetic rats. / Papel dos leucotrienos na fagocitose via FcgR por macrofágos alveolares de ratos sadios e diabéticos.
Avaliamos o papel dos leucotrienos (LTs), as vias de sinalização e o efeito da insulina na fagocitose via FcgR por macrófagos alveolares (MAs) de ratos sadios (RS) e diabéticos (RD). Vimos que a) MAs de RD fagocitam menos que os de RS; b) a fagocitose é dependente de LTs endógenos em RS mas não em RD; c) a adição de LTB4 ou LTD4 aos MAs em cultura a
Publicado em: 2009
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14. Planejamento, síntese e avaliação farmacológica de novos candidatos a protótipos de fármacos anti-inflamatários, desenhados a partir do nerolidilcatecol / Planning, synthesis and pharmacological evaluation of new candidates for prototypes of anti-inflamatários, drawn from the nerolidylcatechol
Inflammation is a local reaction of tissue involving neurological, vascular, humoral and cellular reactions to eliminate the causal agents and reduce the cellular damages. Prostaglandins, thromboxanes and leukotrienes are examples of chemical inflammation mediators, resulting for the action of the enzyme phospholipase A2 (PLA2). The PLA is a enzyme that hydr
Publicado em: 2009
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15. Avaliação das atividades analgesica e antiinflamatoria da fração hexanica Agave sisalana / Evaluation of activities analgesic and anti-inflammatory of hexanic fraction of Agave sisalana
Pain is defined as complex and vague sensation that involves several factors such as life style and environment. Many times pain is a result of an inflammatory process. The inflammation an imune system response to different kind of stimulus, microorganisms, tissue injuries, miogenic stimulus or even cirurgic traumas, which release several endogens mediators.
Publicado em: 2009
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16. Studies about the effects of the in vivo administration of Leukotriene B4 or Prostaglandin E2-loaded biodegradable microspheres on model of murine histoplasmosis / Estudos sobre os efeitos da administração in vivo de microesferas biodegradáveis contendo Leucotrieno B4 ou Prostaglandina E2 em modelo de histoplasmose murina
Leukotrienes and prostaglandins are arachidonic acid metabolites, which participate in the inflammatory response and modulate cytokines release in both adaptive and innate immune responses. However, some physicochemical characteristics of these mediators, such as poor solubility in water and chemical instability, make them difficult to administer in vivo. In
Publicado em: 2008
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17. Novas Tiazolidinadionas 3, 5-Dissubstituidas: sÃntese, comprovaÃÃo estrutural e avaliaÃÃo da atividade antiinflamatÃria
To the thiazolidinic nucleus, due to their chemical reactivity, are atributed several biological activities, fact that directed our research in search of new biologically active agents. Recent studies have demonstrated the potential of thiazolidinics derivatives in inhibiting the inflammatory response, characterized by the release of various endogenous pro-i
Publicado em: 2008
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18. Comparison of pre- versus post-incision administration of intraplantar indomethacin and MK886 in a rat model of postoperative pain
The amplification of pain long after the initial stimulus may be avoided if the treatment of pain is introduced before its initiation. However, conflicting evidence exists about the efficacy of such preemptive analgesia for the management of postoperative pain. This study compares the efficacy of intraplantar administration of indomethacin (a non-selective i
Brazilian Journal of Medical and Biological Research. Publicado em: 22/06/2007
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19. Effect of the cysteinyl-leukotrienes on the production of eosinophils in culture of bone marrow: direct actions, mediation of the actions of the indometacina and the aspirin, and regulation of the reply to the PGE2. / Efeitos dos cisteinil-leucotrienos sobre a produção de eosinófilos em cultura de medula óssea: ações diretas, mediação das ações da indometacina e da aspirina, e regulação da resposta à PGE2.
Cysteinyl-Leukotrienes (CysLT) are important mediators of asthma, which induce bronchoconstriction, mucus secretion and a variety of regulatory effects on the infiltrating leukocyte populations, especially eosinophils. Increased CysLT production resulting from the shunting of arachidonic acid towards the 5-lipoxygenase (5-LO) pathway in the absence of active
Publicado em: 2007
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20. Participation of leukotrienes in vasopressin secretion during experimental sepsis / Participação dos leucotrienos na secreção de vasopressina durante sepse experimental
Durante a sepse ocorre aumento da produção de mediadores inflamatórios, dentro os quais leucotrienos (LTs), além de hipotensão seguida de aumento da secreção de vasopressina (AVP) na fase inicial e diminuição na fase tardia, a despeito da progressão da hipotensão. Estudos recentes revelam que neurônios vasopressinérgicos contêm alto conteúdo d
Publicado em: 2007
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21. Papel da 5-Lipoxigenase no controle da carga parasitária e no estresse oxidaltivo de eritrócitos durante a fase aguda da infecção experimental com Trypanosoma cruzi
Recently, it was demonstrated that nitric oxide (NO) produced during Trypanosoma cruzi infection participates of erythrocyte oxidative stress, but is not necessary for the development of anemia in the acute phase of infection in mice. In this work it was investigated the effect of inhibition of leukotrienes (LTs) by pharmacological or genetic blocking of the
Publicado em: 2007
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22. Nitric oxide: a major determinant of mast cell phenotype and function
Mast cells (MC) are important in the numerous physiological processes of homeostasis and disease. Most notably, MC are critical effectors in the development and exacerbation of allergic disorders. Nitric oxide (NO) is a diatomic radical produced by nitric oxide synthase (NOS), and has pluripotent cell signaling and cytotoxic properties. NO can influence many
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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23. Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients
Lipids used in nutritional support of surgical or critically ill patients have been based on soybean oil, which is rich in the n-6 fatty acid linoleic acid (18:2n-6). Linoleic acid is the precursor of arachidonic acid (20:4n-6). In turn, arachidonic acid in cell membrane phospholipids is the substrate for the synthesis of a range of biologically active compo
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-04
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24. Estudo dos fatores determinantes do grau de infectividade de linhagens de Strongyloides venezuelensis e analise de antigenos heterologos no imunodiagnostico da estrongiloidiase humana
In this study, we have shown that, in mice, L-2 and L-49 strains of S. venezuelensis induced an increase in the total number of leukocytes, eosinophils (EO) and mononuclear cells in blood, peritoneal cavity (LCP) and in the bronchoalveolar space (LBA), in a similar manner. Both strains stimulated synthesis of TH1 or TH2 type immune response cytokines, with a
Publicado em: 2003