Leishmanicidal
Mostrando 13-24 de 127 artigos, teses e dissertações.
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13. Second-generation pterocarpanquinones: synthesis and antileishmanial activity
Abstract Background: Despite the development of new therapies for leishmaniasis, among the 200 countries or territories reporting to the WHO, 87 were identified as endemic for Tegumentary Leishmaniasis and 75 as endemic for Visceral Leishmaniasis. The identification of antileishmanial drug candidates is essential to fill the drug discovery pipeline for leis
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 17/12/2018
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14. Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach
Abstract Background: Considering the high toxicity and limited therapies available for treating visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to deliver new therapies to the market. Methods: In this study, we described for the first time the activity of a potent antiarrhythmic, amiodarone (AMD), against L. (L.)infantu
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/11/2018
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15. Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) amazonensis
Abstract Background: Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses prostaglandins to evade innate barriers, thus enabling the parasites to survive inside immune cells. Despite the role of the enzyme Phospholipase A2 (PLA2) in prostaglandins production, few studies have inve
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 21/09/2018
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16. Phenolic Composition and Leishmanicidal Activity of Red Propolis and Dalbergia ecastaphyllum (L.) Taub (Fabaceae) Extracts from Sergipe, Brazil
ABSTRACT Leishmaniasis is a parasitic disease caused by protozoa of the Leishmania genus. It may manifest in visceral and tegumentary forms, and pentavalent antimonials are the first choice drugs used for the treatment. Frequently these drugs show low efficiency and high toxicity to mammalian host. The present study describes the chemical profile and the in
Braz. arch. biol. technol.. Publicado em: 06/08/2018
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17. Evaluation of anxiolytic-like effect of 7-epiclusianone isolated from Garcinia brasiliensis in mice
ABSTRACT Garcinia brasiliensis Mart., Clusiaceae, species became the target of studies for some years because it has several compounds including polyprenylated benzophenones, as 7-epiclusianone. This benzophenone has several properties, such as leishmanicidal, anti-inflammatory and antinociceptive effects, however still did not be studied anxiolytic activity
Rev. bras. farmacogn.. Publicado em: 2018-06
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18. Design, Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel Eugenol Esters as Leishmanicidal Agents
Leishmaniasis is a neglected pathology with a high incidence worldwide, and is a governmental health issue due to the increased morbidity and mortality associated with the disease and a scarce therapeutic arsenal. Cysteine proteases have been investigated as targets for new drugs because they are essential in the infectivity of the parasite during its intera
J. Braz. Chem. Soc.. Publicado em: 2018-04
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19. In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195
BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in many countries, including Brazil. Currently available treatments require long-term use and have serious side effects, necessitating the development of new therapeutic interventions. Because translocator protein (TSPO) levels are reduced in Leishmania amazonen
Mem. Inst. Oswaldo Cruz. Publicado em: 05/02/2018
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20. Leishmanicidal compounds of Nectria pseudotrichia, an endophytic fungus isolated from the plant Caesalpinia echinata (Brazilwood)
BACKGROUND In a screen of extracts from plants and fungi to detect antileishmanial activity, we found that the ethyl acetate extract of the fungus Nectria pseudotrichia, isolated from the tree Caesalpinia echinata (Brazilwood), is a promising source of bioactive compounds. OBJECTIVES The aims of this study were to isolate and determine the chemical structu
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-02
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21. REPARAÇÃO DE α-ACETILOXI-N-CICLOEXILAMIDAS ATRAVÉS DA REAÇÃO DE PASSERINI UTILIZANDO DIMETILCARBONATO COMO SOLVENTE AMBIENTALMENTE AMIGÁVEL
A series of α-acetyloxy-N-cyclohexylamides was efficiently obtained via Passerini reaction of cyclohexyl isocyanide, acetic acid, and different aromatic and aliphatic aldehydes using refluxing dichloromethane or dimethylcarbonate (DMC). Reactions performed with DMC led to desired products in moderate to good yields, corroborating this solvent as a eco-frien
Quím. Nova. Publicado em: 2018-01
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22. Vouacapane diterpenoids isolated from Pterodon and their biological activities
Abstract The Pterodon genus comprises two native species in Brazil, known as “sucupira-branca” or “faveira”. Their fruits have long been used in Brazilian natural medicine, mainly for the treatment of infections and inflammations. The pharmacological properties of these fruits have often been linked with vouacapane diterpenoids. This review evaluated
Rev. bras. farmacogn.. Publicado em: 2017-10
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23. Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans
Abstract Background: Among the hymenopteran insect venoms, those from social wasps and bees - such as honeybee, hornets and paper wasps - have been well documented. Their venoms are composed of a number of peptides and proteins and used for defending their nests and themselves from predators. In contrast, the venoms of solitary wasps and bees have not been
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 28/09/2017
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24. A New Furanoheliangolide Sesquiterpene Lactone from Calea pinnatifida (R. Br.) Less. (Asteraceae) and Evaluation of Its Trypanocidal and Leishmanicidal Activities
Calea pinnatifida (R. Br.) Less. is commonly known in Brazil as "cipó-cruz", "quebra-tudo" or "aruca". This species is employed in folk medicine as giardicidal, amoebicidal and to treat digestive disorders. The present paper describes the isolation and structure determination of a new furanoheliangolide sesquiterpene lactone named 11,13-dihydroxy-calaxin, i
J. Braz. Chem. Soc.. Publicado em: 2017-02