Leishmania Rna Virus 1 4
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Correlação entre a presença de Leishmania RNA Vírus 1 e as características clínicas da leishmaniose de mucosa nasal
RESUMO Introdução: A leishmaniose de mucosa (LM) é uma forma clínica grave da leishmaniose. Fatores complexos ligados ao parasita e ao hospedeiro são atribuídos ao desenvolvimento das lesões de mucosa. Leishmania RNA Vírus 1 (LRV1) pode subverter a resposta imune, podendo ser o principal determinante da gravidade da doença e deve ser pesquisado. O
Braz. j. otorhinolaryngol.. Publicado em: 2015-10
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2. An improved purification procedure for Leishmania RNA virus (LRV)
Leishmania RNA Virus (LRV, Totiviridae) infect Leishmania cells and subvert mice immune response, probably promoting parasite persistence, suggesting significant roles for LRV in host-parasite interaction. Here we describe a new LRV1-4 purification protocol, enabling capsid visualization by negatively stained electron microscopy representing a significant co
Braz. J. Microbiol.. Publicado em: 2014-06
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3. Expressão, purificação e caracterização do Leishmania RNA Virus 1-4 e da proteína U5-15k do Tripanosoma brucei / Expression, purification and caracterization of Leishmania RNA Virus 1-4 and U5-15k protein of Tripanosoma bruceiem
O estudo dos protozoários é importante por diversos motivos, entre eles sua diversidade, sua importância evolucionária e impacto na saúde pública. Muitos aspectos tornam o estudo desses seres vivo ainda mais fascinantes, como por exemplo, fenômenos como o trans-splincing e a presença de um vírus em algumas espécies de leishmanias. A proteína U5-15
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/09/2012
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4. Identificação, classificação e anotação de enzimas desubiquitinadoras e ubiquitina-símile em Trypanosoma cruzi
O sequenciamento do genoma de Leishmania major, Trypanosoma cruzi e T. brucei mostrou que cada genoma contém entre 8300-1200 genes que codificam proteínas, dos quais aproximadamente 6500 são comuns entre estas espécies. Neste estudo nós focamos a busca nos bancos de dados de tripanossomatídeos por proteínas envolvidas com o metabolismo de ubiquitina.
Publicado em: 2009
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5. Influência do vírus da hepatite G (GBV-C) na resposta imune frente à infecção por Leishmania chagasi
GBV-C é um vírus membro da família dos Flavivirus, que tem um aparente papel indutor da resposta Th1 e está associado ao prolongamento da sobrevida, em pessoas infectadas com HIV. L. chagasi é responsável por um amplo espectro que variam da forma assintomática, com resolução espontânea da infecção e, consecutivamente, desenvolvimento resposta pos
Publicado em: 2001
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6. Hygromycin B resistance mediates elimination of Leishmania virus from persistently infected parasites.
A series of pX63-HYG derivatives encoding Leishmania RNA virus 1-4 (LRV1-4) sequences were electroporated into cells of Leishmania strain M4147, a virus-infected strain of L. guyanensis. After 6 weeks of drug selection (hygromycin B), transfected parasites lacked detectable quantities of viral genomic double-stranded RNA, viral capsid protein, and RNA-depend
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7. Synthesis of viruslike particles by expression of the putative capsid protein of Leishmania RNA virus in a recombinant baculovirus expression system.
The putative capsid open reading frame (ORF2) of the Leishmania RNA virus LRV1-4 was expressed in a baculovirus expression system. The expressed protein was identified by Western immunoblot analysis with polyclonal antiserum raised to purified LRV1-4 virus. Electron microscopy and sedimentation analysis indicated that the expressed protein self-assembles int
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8. Mutational analysis of the capsid protein of Leishmania RNA virus LRV1-4.
The virion of Leishmania RNA virus is predicted to be composed of a 742-amino-acid major capsid protein and a small percentage of capsid-polymerase fusion molecules. Recently, the capsid protein alone was expressed and shown to spontaneously assemble into viruslike particles. Since the major structural protein of the virion shell self-assembles into viruslik
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9. Phylogenetic analysis of Leishmania RNA virus and Leishmania suggests ancient virus-parasite association.
Some strains of the protozoan parasite Leishmania belonging to the new world species guyanensis and braziliensis are infected with persistent, single-segmented, non-enveloped dsRNA viruses termed LRV1. A single old world strain classified as L. major was recently found to harbor a similar virus, designated LRV2-1. The genomic nucleotide sequences of two LRV1
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10. Identification of the Minimal Essential RNA Sequences Responsible for Site-Specific Targeting of the Leishmania RNA Virus 1-4 Capsid Endoribonuclease
The Leishmania RNA virus 1-4 capsid protein possesses an endoribonuclease activity responsible for single-site-specific cleavage within the 450-nucleotide 5′ untranslated region of its own viral RNA transcript. To characterize the minimal essential RNA determinants required for site-specific cleavage, mutated RNA transcripts were examined for susceptibilit
American Society for Microbiology.
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11. LRV1 viral particles in Leishmania guyanensis contain double-stranded or single-stranded RNA.
The 32-nm-diameter spherical viral particles found in the cytoplasm of Leishmania guyanensis CUMC1-1A sediment at 130S and have a buoyant density of approximately 1.4 g/ml in cesium chloride gradients. These particles contain a 5.3-kb double-stranded RNA, while single-stranded RNA that corresponds to the viral positive strand is associated with less-dense pa
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12. Specific in vitro cleavage of a Leishmania virus capsid-RNA-dependent RNA polymerase polyprotein by a host cysteine-like protease.
Antibodies raised against baculovirus-expressed RNA-dependent RNA polymerase (RDRP) recognized a 95-kDa antigen and two smaller proteins in sucrose-purified Leishmania virus particles isolated from infected parasites. The 95-kDa antigen is similar in size to one predicted by translation of the RDRP open reading frame (ORF) alone. In an effort to reconcile in