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Mostrando 37-48 de 66 artigos, teses e dissertações.
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37. The dissociation of acetylcholine from open nicotinic receptor channels
Ligand-gated ion channels bind agonists with higher affinity in the open than in the closed state. The kinetic basis of this increased affinity has remained unknown, because even though the rate constants of agonist association to and dissociation from closed receptors can be estimated with reasonable certainty, the kinetics of the binding steps in open rece
The National Academy of Sciences.
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38. Epilepsy and employment. A community based survey in an area of high unemployment.
A community based survey was undertaken to assess the work record of patients with epilepsy in an area of high unemployment. One hundred and thirty seven epileptic patients were identified from a population of 23,837 persons of employable age registered with three urban group practices in North East England. The unemployment rate for economically active pati
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39. Barriers to recombination between closely related bacteria: MutS and RecBCD inhibit recombination between Salmonella typhimurium and Salmonella typhi
Previous studies have shown that inactivation of the MutS or MutL mismatch repair enzymes increases the efficiency of homeologous recombination between Escherichia coli and Salmonella typhimurium and between S. typhimurium and Salmonella typhi. However, even in mutants defective for mismatch repair the recombination frequencies are 102- to 103-fold less than
The National Academy of Sciences of the USA.
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40. Comparison of the effects of some thiamine analogues upon thiamine transport across the blood-brain barrier of the rat.
The flux of thiamine from the blood into the brain has been measured by a specially devised procedure in which a steady raised level of the vitamin, with or without radioactive labelling, was achieved rapidly and maintained steadily in the circulating blood plasma. This was done by a single rapid I.V. injection followed by a continuous injection given at a r
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41. Lung cancer in relation to employment in the electrical utility industry and exposure to magnetic fields.
OBJECTIVES: A recent study found that lung cancer may be associated with exposures encountered in the electrical utility industry. To further evaluate this possibility, data were collected and analysed from five large electrical utility companies in the United States. METHODS: A cohort of 138905 male workers employed between 1950 and 1986 was followed up for
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42. Persistence of DNA synthesis arrest sites in the presence of T4 DNA polymerase and T4 gene 32, 44, 45 and 62 DNA polymerase accessory proteins.
DNA synthesis by phage T4 DNA polymerase is arrested at specific sequences in single-stranded DNA templates. To determine whether or not T4 DNA polymerase accessory proteins 32, 44, 45 and 62 eliminated recognition of these arrest sites, unique primer-templates were constructed in which DNA synthesis began at a DNA primer located at different distances from
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43. Salbutamol in cardiogenic shock complicating acute myocardial infarction.
Intravenous salbutamol (13 microgram/min) has been given to 31 patients with cardiogenic shock complicating acute myocardial infarction. Haemodynamic measurements were made in nine of these patients. Salbutamol increased cardiac index by 41 per cent from 1.25 +/- 0.06 l/min per m2 to 1.76 +/- 0.19 l/min per m2 and decreased systemic vascular resistance by 16
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44. Evidence that the RNA Polymerase Usually Does Not Make a Complete Transcript of the Late Strand of Simian Virus 40 DNA
An important model for the transcription of the late (L) strand of simian virus 40 DNA is that, late after infection of permissive monkey cells, the RNA polymerase makes a complete transcript of the L DNA strand before terminating transcription. The purpose of the current work was to test a prediction of this model, namely, that the rate of synthesis of all
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45. Inhibition of thiamine transport across the blood-brain barrier in the rat by a chemical analogue of the vitamin.
The flux of thiamine from the blood into the brain has been measured using a specially devised technique by which a steady raised level of the vitamin, with or without radioactive labelling, can be achieved rapidly and maintained in the bloodstream. This is done by a continuous injection, given at a rate which is adjusted by a pre-determined programme so as
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46. Spontaneous Current Pulses Through Developing Fucoid Eggs
Using a newly developed, extracellular vibrating electrode, we can now measure the electrical currents that traverse a single developing cell. We have studied the eggs of the common seaweed, Pelvetia, during their first 2 days of development and find that the endogenous electrical current through them includes a pulse component as well as a relatively steady
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47. Work disability in early rheumatoid arthritis.
OBJECTIVE--To assess the impact of early rheumatoid arthritis (RA) on work status. METHODS--The employment status of 119 patients who had jobs before the onset of RA was examined. Patients with work disability were compared with those without, for several disease characteristics, therapeutic regimen, and educational level and age. RESULTS--Sixty two percent
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48. Newcastle satisfaction with nursing scales: an instrument for quality assessments of nursing care.
OBJECTIVES--To test the validity and reliability of scales for measuring patients' experiences of and satisfaction with nursing care; to test the ability of the scales to detect differences between hospitals and wards; and to investigate whether place of completion, hospital, or home influences response. DESIGN--Sample survey. SETTING--20 wards in five hospi