Landscape Preference
Mostrando 13-15 de 15 artigos, teses e dissertações.
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13. Watching proteins fold one molecule at a time
Recent theoretical work suggests that protein folding involves an ensemble of pathways on a rugged energy landscape. We provide direct evidence for heterogeneous folding pathways from single-molecule studies, facilitated by a recently developed immobilization technique. Individual fluorophore-labeled molecules of the protein adenylate kinase were trapped wit
The National Academy of Sciences.
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14. Domain swapping is a consequence of minimal frustration
The same energy landscape principles associated with the folding of proteins into their monomeric conformations should also describe how these proteins oligomerize into domain-swapped conformations. We tested this hypothesis by using a simplified model for the epidermal growth factor receptor pathway substrate 8 src homology 3 domain protein, both of whose m
National Academy of Sciences.
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15. Roles of mutation and recombination in the evolution of protein thermodynamics
We present a comprehensive study of the evolutionary origin of the thermodynamic behavior of proteins. With the use of a simplified model, we exhaustively enumerate the space of all sequences and the space of all structures, simulate the evolutionary relationship between sequences and structures, and characterize the steady-state sequence distribution for al
National Academy of Sciences.