L Asparaginase
Mostrando 1-12 de 84 artigos, teses e dissertações.
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1. Allergic reactions to asparaginase: retrospective cohort study in pediatric patients with acute lymphoid leukemia
ABSTRACT Introduction: To assess the frequency of allergic reactions to asparaginase (ASP) and possible risk factors for reactions in a cohort of pediatric patients. Method: The study was performed based on retrospective data from patients under acute lymphoid leukemia treatment in a general university hospital located in southern Brazil. Information on pa
Hematol., Transfus. Cell Ther.. Publicado em: 2021-03
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2. Asparaginase: an old drug with new questions
ABSTRACT The long-term outcome of acute lymphoblastic leukemia has improved dramatically due to the development of more effective treatment strategies. L-asparaginase (ASNase) is one of the main drugs used and causes death of leukemic cells by systematically depleting the non-essential amino acid asparagine. Three main types of ASNase have been used so far:
Hematol., Transfus. Cell Ther.. Publicado em: 2020-09
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3. PEG-asparaginase and native Escherichia coli L-asparaginase in acute lymphoblastic leukemia in children and adolescents: a systematic review
Abstract Introduction Acute lymphoblastic leukemia (ALL) is the cancer with the highest incidence in childhood and adolescence, and pharmacotherapy is the primary form of treatment. Objective and methods A systematic review of the efficacy and safety of polyethylene glycol (PEG)-asparaginase in acute lymphoblastic leukemia therapy in children and adolescen
Hematol., Transfus. Cell Ther.. Publicado em: 2020-03
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4. Fungal endophyte diversity in the leaves of the medicinal plant Myracrodruon urundeuva in a Brazilian dry tropical forest and their capacity to produce L-asparaginase
ABSTRACT We studied the fungal endophyte community of the leaves of Myracrodruon urundeuva in Brazil along with their potential to produce L-asparaginase. In total, 187 endophytes were isolated. The colonization rate of leaf fragments from caatinga (10.41 %) was lower than those from brejo de altitude (39.58 %). Sequences of ITS rDNA from all endophytes reve
Acta Bot. Bras.. Publicado em: 21/09/2018
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5. Do immunoglobulin G and immunoglobulin E anti-l-asparaginase antibodies have distinct implications in children with acute lymphoblastic leukemia? A cross-sectional study
Abstract Background l-Asparaginase is essential in the treatment of childhood acute lymphoblastic leukemia. If immunoglobulin G anti-l-asparaginase antibodies develop, they can lead to faster plasma clearance and reduced efficiency as well as to hypersensitivity reactions, in which immunoglobulin E can also participate. This study investigated the presence
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-09
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6. Current applications and different approaches for microbial L-asparaginase production
ABSTRACT L-asparaginase (EC 3.5.1.1) is an enzyme that catalysis mainly the asparagine hydrolysis in L-aspartic acid and ammonium. This enzyme is presented in different organisms, such as microorganisms, vegetal, and some animals, including certain rodent's serum, but not unveiled in humans. It can be used as important chemotherapeutic agent for the treatmen
Braz. J. Microbiol.. Publicado em: 2016-12
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7. Compras federais de antineoplásicos no Brasil: análise do mesilato de imatinibe, trastuzumabe e L-asparaginase, 2004-2013
Resumo Objetivo: Analisar o perfil das compras realizadas por órgãos federais brasileiros dos antineoplásicos mesilato de imatinibe, trastuzumabe e L-asparaginase, entre janeiro/2004 e dezembro/2013. Métodos: Dados de compras foram extraídos do Sistema Integrado de Administração de Serviços Gerais-SIASG. Foram analisados: quantidade, preço unitár
Physis. Publicado em: 2016-10
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8. PEG-asparaginase induced severe hypertriglyceridemia
Asparaginase (ASP) is an effective chemotherapy agent extensively used in children with acute lymphocytic leukemia (ALL). There has been a recent interest in using ASP in adults with ALL, particularly the less toxic pegylated (PEG) formulation. Hypertriglyceridemia (HTG) is a rare complication of PEG-ASP therapy. We report two cases of obese patients who dev
Arch. Endocrinol. Metab.. Publicado em: 28/08/2015
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9. Recombinant Erwinia carotovora l-asparaginase II production in Escherichia coli fed-batch cultures
Asparaginases are the cornerstone therapy of many successful combination regimens for the treatment of acute lymphoblastic leukemia (ALL), the most common malignancy in children and adolescents. The aim of this work was to produce recombinant Erwinia carotovora L-asparaginase II in Escherichia coli fed-batch cultures. Using a robust fed-batch technique with
Braz. J. Chem. Eng.. Publicado em: 2013-06
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10. Salinidade, sodicidade e propriedades microbiológicas de Argissolo cultivado com erva-sal e irrigado com rejeito salino.
O objetivo deste trabalho foi avaliar o efeito da irrigação com rejeito da dessalinização, oriundo de tanques de produção de tilápia-rosa, sobre as propriedades químicas e microbiológicas de solos cultivados com erva-sal (Atriplex nummularia Lindl.). Quatro áreas foram usadas, das quais duas foram irrigadas com rejeito salino e cultivadas, durante
Pesquisa Agropecuária Brasileira. Publicado em: 2011
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11. Efeito da salinidade sobre a atividade enzimática em solos de região semi-árida do Brasil.
A salinização do solo pode ocorrer por um processo natural ou ser induzida pelo homem (salinização secundária), devido às conseqüências do manejo impróprio da irrigação, má condição de drenagem ou má qualidade da água de irrigação. Estudos realizados no nordeste brasileiro demonstraram que o cultivo de Atriplex nummularia em áreas que rece
CONGRESSO VIRTUAL IBEROAMERICANO SOBRE GESTION DE CALIDAD EN LABORATORIOS. Publicado em: 2011
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12. Production, purification and characterization of L-asparaginase from Streptomyces gulbargensis
L-asparaginase is an anti-neoplastic agent used in the lymphoblastic leukaemia chemotherapy. In the present study a novel strain, Streptomyces gulbargensis was explored for the production of extra-cellular L-asparaginase using groundnut cake extract. The optimum pH, temperature, inoculum size and agitation speed for enzyme production were pH 8.5, 40ºC, 1x10
Brazilian Journal of Microbiology. Publicado em: 2010-03