Kinesin
Mostrando 1-12 de 317 artigos, teses e dissertações.
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1. Atividade anti-tumoral do composto LaSOM 65, derivado do monastrol, em linhagens de gliomas
Gliomas are the most common primary cancer in the central nervous system. Despite recent progress in the treatment of glioblastoma, the median survival of the patients still remains at 15 months. Kinesin Spindle Protein (KSP) has been reported as an interesting target for cancer therapy. Followed by the first specific KSP inhibitor, Monastrol, several other
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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2. Prolactina potencializa a secreção de insulina via formação do complexo SNARE em ilhotas pancreaticas / Prolactin modulates the insulin secretion by SNARE complex formation in neonatal rat islets
Prolactin induces maturation of insulin secretion in cultured neonatal rat islets. In this study, we investigated whether the improved secretory response to glucose caused by prolactin involves alteration in the expression, association and phosphorylation of several proteins that participate in these processes. Messenger RNA was extracted from neonatal rat i
Publicado em: 2006
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3. Antígenos da forma amastigota de Leishmania chagasi identificados por dupla varredura da biblioteca de cDNA
Control of human visceral leishmaniasis in endemic regions is hampered in part by the lack of knowledge with respect of the role reservoirs and vector. In addition, there is not yet an understanding of how non-symptomatic subclinical infection might influence the maintenance of infection in a particular locality. Of worrisome is the limited accessibility to
Publicado em: 2006
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4. Release of Kinesin from Vesicles by hsc70 and Regulation of Fast Axonal Transport
The nature of kinesin interactions with membrane-bound organelles and mechanisms for regulation of kinesin-based motility have both been surprisingly difficult to define. Most kinesin is recovered in supernatants with standard protocols for purification of motor proteins, but kinesin recovered on membrane-bound organelles is tightly bound. Partitioning of ki
The American Society for Cell Biology.
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5. An Internal Motor Kinesin Is Associated with the Golgi Apparatus and Plays a Role in Trichome Morphogenesis in Arabidopsis
Members of the kinesin superfamily are microtubule-based motor proteins that transport molecules/organelles along microtubules. We have identified similar internal motor kinesins, Kinesin-13A, from the cotton Gossypium hirsutum and Arabidopsis thaliana. Their motor domains share high degree of similarity with those of internal motor kinesins of animals and p
The American Society for Cell Biology.
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6. Mechanics of single kinesin molecules measured by optical trapping nanometry.
We have analyzed the mechanics of individual kinesin molecules by optical trapping nanometry. A kinesin molecule was adsorbed onto a latex bead, which was captured by an optical trap and brought into contact with an axoneme that was bound to a glass surface. The displacement of kinesin during force generation was determined by measuring the position of the b
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7. The Kinesin-associated Protein UNC-76 Is Required for Axonal Transport in the Drosophila Nervous System
Kinesin-I is essential for the transport of membrane-bound organelles in neural and nonneural cells. However, the means by which kinesin interacts with its intracellular cargoes, and the means by which kinesin–cargo interactions are regulated in response to cellular transport requirements are not fully understood. The C terminus of the Drosophila kines
The American Society for Cell Biology.
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8. Allele-specific activators and inhibitors for kinesin
Members of the kinesin superfamily are force-generating ATPases that drive movement and influence cytoskeleton organization in cells. Often, more than one kinesin is implicated in a cellular process, and many kinesins are proposed to have overlapping functions. By using conventional kinesin as a model system, we have developed an approach to activate or inhi
The National Academy of Sciences.
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9. Fast axonal transport of kinesin in the rat visual system: functionality of kinesin heavy chain isoforms.
The mechanochemical ATPase kinesin is thought to move membrane-bounded organelles along microtubules in fast axonal transport. However, fast transport includes several classes of organelles moving at rates that differ by an order of magnitude. Further, the fact that cytoplasmic forms of kinesin exist suggests that kinesins might move cytoplasmic structures s
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10. Kinesin-73 in the nervous system of Drosophila embryos
Kinesin-73 cDNA was shown to encode a kinesin heavy chain protein that contains an N-terminal motor domain and a long central region that lacks extensive coiled–coils. The amino acid sequence of the motor domain of kinesin-73 protein is most closely related to the motor domains of Caenorhabditis elegans unc-104 and mouse KIF1A. The central region of kinesi
National Academy of Sciences.
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11. Modulation of kinesin binding by the C-termini of tubulin
The flexible tubulin C-terminal tails (CTTs) have recently been implicated in the walking mechanism of dynein and kinesin. To address their role in the case of conventional kinesin, we examined the structure of kinesin–microtubule (MT) complexes before and after CTT cleavage by subtilisin. Our results show that the CTTs directly modulate the motor–tubuli
Nature Publishing Group.
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12. Kinesin molecular motors: Transport pathways, receptors, and human disease
Kinesin molecular motor proteins are responsible for many of the major microtubule-dependent transport pathways in neuronal and non-neuronal cells. Elucidating the transport pathways mediated by kinesins, the identity of the cargoes moved, and the nature of the proteins that link kinesin motors to cargoes are areas of intense investigation. Kinesin-II recent
The National Academy of Sciences.