Kidney Physiology
Mostrando 13-24 de 49 artigos, teses e dissertações.
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13. Estudo das alterações renais e vasculares induzidas pelo veneno de Tityus serrulatus / Study of renal and blood vessel alterations induced by Tityus serrulatus venom
According to the Brazilian Ministry of Health, about 8000 cases of scorpion envenomation are reported yearly in Brazil. Most cases are due to the sting of Tityus serrulatus, known popularly as yellow scorpion. It belongs to the Arachnidea, class, Scorpionidae order, Buthidae family, Tityinae subfamily and Tityus genus. It is present in the Brazilian States o
Publicado em: 2005
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14. Efeitos da insuficiência renal aguda sobre o esvaziamento gástrico e trânsito gastrintestinal de líquido em ratos acordados / Efects of acute renal failure on gastric emptying and on gastrointestinal transit of liquid in awake rats
Renal failure leads to important gastrointestinal functional changes. However, there are only few studies focused on the relationship between renal failure and gastrointestinal tract physiology. In this work we studied the gastric emptying (GE) and gastrointestinal (GI) transit of liquid 6, 12 and 24hr after awake rats had one or both kidneys surgically remo
Publicado em: 2003
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15. An update on the physiology of two- and three-toed sloths
Physiological and pharmacological research undertaken on sloths during the past 30 years is comprehensively reviewed. This includes the numerous studies carried out upon the respiratory and cardiovascular systems, anesthesia, blood chemistry, neuromuscular responses, the brain and spinal cord, vision, sleeping and waking, water balance and kidney function an
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-02
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16. Regulation of mRNA translation in renal physiology and disease
Translation, a process of generating a peptide from the codons present in messenger RNA, can be a site of independent regulation of protein synthesis; it has not been well studied in the kidney. Translation occurs in three stages (initiation, elongation, and termination), each with its own set of regulatory factors. Mechanisms controlling translation include
American Physiological Society.
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17. A Transcriptional Profile of Aging in the Human Kidney
In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile i
Public Library of Science.
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18. Gene Expression in the Normal Adult Human Kidney Assessed by Complementary DNA Microarray
The kidney is a highly specialized organ with a complex, stereotyped architecture and a great diversity of functions and cell types. Because the microscopic organization of the nephron, the functional unit of the kidney, has a consistent relationship to the macroscopic anatomy of the kidney, knowledge of the characteristic patterns of gene expression in diff
The American Society for Cell Biology.
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19. Salt handling and hypertension
The kidney plays a central role in our ability to maintain appropriate sodium balance, which is critical to determination of blood pressure. In this review we outline current knowledge of renal salt handling at the molecular level, and, given that Westernized societies consume more salt than is required for normal physiology, we examine evidence that the low
American Society for Clinical Investigation.
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20. Who is at increased risk for acute kidney injury following noncardiac surgery?
Abelha and colleagues evaluated the incidence and determinants of postoperative acute kidney injury (AKI) after major noncardiac surgery in patients with previously normal renal function. In this retrospective study of 1,166 patients with no previous renal insufficiency, who were admitted to a postsurgical intensive care unit (ICU) over a 2-year period, the
BioMed Central.
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21. A comprehensive guide to the ROMK potassium channel: form and function in health and disease
The discovery of the renal outer medullary K+ channel (ROMK, Kir1.1), the founding member of the inward-rectifying K+ channel (Kir) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, consid
American Physiological Society.
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22. Effects of Organic Anion, Organic Cation, and Dipeptide Transport Inhibitors on Cefdinir in the Isolated Perfused Rat Kidney
Cefdinir (Omnicef; Abbott Laboratories) is a cephalosporin antibiotic primarily eliminated by the kidney. Nonlinear renal elimination of cefdinir has been previously reported. Cefdinir renal transport mechanisms were studied in the erythrocyte-free isolated perfused rat kidney. Studies were performed with drug-free perfusate and perfusate containing cefdinir
American Society for Microbiology.
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23. The Rab5 Effector Rabankyrin-5 Regulates and Coordinates Different Endocytic Mechanisms
The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functionally cooperate in membrane tethering, fusion, and organelle motility. Here we discovered a novel PI(3)P-binding
Public Library of Science.
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24. MRP3, an organic anion transporter able to transport anti-cancer drugs
The human multidrug-resistance protein (MRP) gene family contains at least six members: MRP1, encoding the multidrug-resistance protein; MRP2 or cMOAT, encoding the canalicular multispecific organic anion transporter; and four homologs, called MRP3, MRP4, MRP5, and MRP6. In this report, we characterize MRP3, the closest homolog of MRP1. Cell lines were retro
The National Academy of Sciences.