Ketanserin
Mostrando 1-12 de 50 artigos, teses e dissertações.
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1. O que se preconiza nos curativos de úlceras arteriais de membros inferiores em pacientes diabéticos?
Encontramos uma revisão sistemática na base de dados Cochrane que tinha como objetivo principal determinar se os agentes tópicos ou curativos afetavam as taxas de cura de úlcera arterial. Os autores relatam ter encontrado apenas dois Ensaios Clínicos Randomizados que preenchiam os critérios de inclusão, porém os estudos tinham pequeno tamanho amos
. Publicado em: 12/06/2023
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2. Qual o melhor tratamento para úlceras de membros inferiores?
Inicialmente é muito importante fazermos o diagnóstico preciso do tipo de úlcera que o paciente apresenta para que possamos individualizar o tratamento e tomar conhecimento das possíveis complicações. Segue abaixo uma diferenciação diagnóstica de cada tipo de úlcera de membros inferiores.
Diagnóstico Diferencial das Úlceras de Membros In
. Publicado em: 12/06/2023
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3. Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation
Pharmacological treatment of inflammatory pain is usually done by administration of non-steroidal anti-inflammatory drugs (NSAIDs). These drugs present high efficacy, although side effects are common, especially gastrointestinal lesions. One of the pharmacological strategies to minimize such effects is the combination of drugs and natural products with syner
Braz J Med Biol Res. Publicado em: 20/06/2016
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4. Interventions for skin changes caused by nerve damage in leprosy
BACKGROUND More than three million persons are disabled by leprosy worldwide. The main complication of sensory nerve damage is neuropathic ulceration, particularly of the feet. In this review we explored interventions that can prevent and treat secondary damage to skin and limbs. OBJECTIVE To assess the effects of self-care, dressings and footwear in prev
Sao Paulo Med. J.. Publicado em: 2013
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5. Antinociceptive effect on mice of the hydroalcoholic fraction and (-) epicatechin obtained from Combretum leprosum Mart & Eich
Previous studies on Combretum leprosum, a tree growing in the Northeastern states of Brazil, have shown antinociceptive effects of the ethanol extract of its leaves and bark, but studies examining its constituents are rare. The objective of this study was to evaluate the antinociceptive effect of the hydroalcoholic fraction (HF) of one of its constituents, t
Braz J Med Biol Res. Publicado em: 2010-12
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6. EVALUATION OF ANTONOCICEPTIVE ACTION OF CRUDE EXTRACT, FRACTIONS AND COMPOUNDS OBTEINED OF Geissospermum vellosii / AVALIAÇÃO DA ATIVIDADE ANTINOCICEPTIVA DO EXTRATO BRUTO, DAS FRAÇÕES E DOS COMPOSTOS OBTIDOS DE Geissospermum vellosii
The present study examined the antinociceptive effects of Geissospermum vellosii in chemical behavioral models of nociception. G. vellosii crude extract, dichloromethane fraction (1-100 mg/kg), or aspidospermine (0.001-1 mg/kg), were administered by p.o. route, 60 min earlier tests. Crude extract produced inhibition of formalin-induced inflammatory nocicepti
Publicado em: 2008
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7. Envolvimento de receptores 5-HT2A da substância cinzenta periaquedutal dorsal no medo condicionado e incondicionado de ratos / 5HT2 receptor mechanisms of the dorsal periaqueductal gray in the conditioned and unconditioned fear in rats
Sabe-se que o medo condicionado contextual (MCC) pode ativar diversas áreas mesencefálicas, como a Substância Cinzenta Periaquedutal Dorsal (SCPd). Diversos estudos avaliaram como mecanismos serotoninérgicos modulam o comportamento defensivo induzido pela estimulação elétrica da SCPd. Uma função proeminente dos receptores 5-HT2A é regular estados a
Publicado em: 2007
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8. "Modulação por mecanismos serotoninérgicos do comportamento exploratório de ratos submetidos ao teste e reteste no labirinto em cruz elevado" / "Modulation by serotonergic mechanisms of the exploratory behavior of rats submitted to the test and retest in the elevated plus-maze"
The elevated plus-maze (EPM) is currently one of the most used test of anxiety. An intriguing feature of this model is the abolition of the anxiolytic effect of benzodiazepines by a single previous experience with the maze. This phenomenon, termed one-trial tolerance (OTT), has received considerable attention and among the several hypotheses suggested to exp
Publicado em: 2006
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9. Maternal aggression in Wistar rats: effect of 5-HT2A/2C receptor agonist and antagonist microinjected into the dorsal periaqueductal gray matter and medial septum
The objective of the present study was to assess the role of the 5-HT2A/2C receptor at two specific brain sites, i.e., the dorsal periaqueductal gray matter (DPAG) and the medial septal (MS) area, in maternal aggressive behavior after the microinjection of either a 5-HT2A/2C receptor agonist or antagonist. Female Wistar rats were microinjected on the 7th pos
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-04
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10. Envolvimento de receptores opióides e serotoninérgicos nos processos antinociceptivos induzidos por substância doce / Involvement of opioid and serotonergic receptors in antinociceptives process induced by sweet substance
Rationale: Sweet substance-induced antinociception has been widely studied, and the investigation of the neurotransmitters involved in the antinociceptive process is an important way for understanding the involvement of neural system controlling this kind of antinociception. Objective: The aim of this study is to investigate the involvement of opioid and ser
Publicado em: 2004
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11. Effect of topical ketanserin administration on intraocular pressure.
The effect of topical ketanserin on intraocular pressure (IOP) in normotensive and hypertensive eyes was evaluated. The study was performed on 10 healthy volunteers and 10 glaucomatous patients. Systolic arterial blood pressure (SBP), diastolic arterial blood pressure (DBP), heart rate (HR), IOP, tonographic outflow facility, pupil diameter, corneal thicknes
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12. Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane (DOM), Ketanserin, and (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in Rats
Very little is known about constitutive activity in vivo. This study examined whether constitutive activity and inverse agonism contribute to discriminative stimulus effects of drugs acting at serotonin (5-HT)2A receptors. Rats were trained to discriminate between saline and either 0.56 mg/kg 5-HT2 receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopro
The American Society for Pharmacology and Experimental Therapeutics.