Kdr
Mostrando 25-36 de 76 artigos, teses e dissertações.
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25. Clonagem e expressão dos domínios 2 e 3 do receptor KDR (VEGFR-2) humano / Cloning and Expression of the 2 and 3 Domains KDR Receptor (VEGFR-2) Human
Em condições patológicas como o câncer, a angiogênese, ou seja, o crescimento de novos vasos a partir de uma rede vascular pré-existente, resulta numa maior oxigenação e nutrição das células e, consequentemente, num rápido crescimento do tumor [1]. Uma variedade de fatores estimulam a angiogênese, entre eles o Fator de Crescimento Endotelial Vas
Publicado em: 2009
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26. Avaliação do papel diagnóstico e prognóstico da expressão imunoistoquímica de NDRG1, osteonectina, VEGF-A, VEGF-C, Flk-1/KDR, HIF-1 e galectina-3 em espécimes tireoideanos por tissue microarrays / Study of the diagnostic and prognostic role of immunohistochemical expression of NDRG1, osteonectin, VEGF-A, VEGF-C, Flk-1/KDR, HIF-1 and galectin-3 in thyroid specimens by tissue microarray
INTRODUÇÃO: O crescimento e a progressão de diversos tipos de tumores dependem da angiogênese, isto é, a formação de novos vasos sanguíneos. Fatores da família do VEGF (VEGF-A, VEGF-C, Flk-1/KDR) são potentes mediadores da angiogênese e níveis elevados destes fatores podem ser detectados em vários tumores humanos. Outras proteínas como NDRG1, o
Publicado em: 2009
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27. eCG e densidade vascular em úteros bovinos / eCG and vascular density of bovine uterus
Follicle dynamic, as well as the uterus preparation for gestation, is dependent of an adequate vascularization establishment. Currently, many studies point towards the importance of eCG treatment following fixed-time artificial insemination (FTAI), in a manner to improve ovulation and gestational rates. Moreover, eCG have been implicated in angiogenesis, lea
Publicado em: 2009
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28. Expressão de fatores angiogênicos em corpo lúteo cíclico e superovulado de búfalas / Expression of angiogenic factors in cyclic and superovulated bufallo corpus luteum
Biotechniques can be an effective way of improving reproduction efficiency and enhancing the production of genetically superior animals. The superovulatory treatment is a common technique aiming to spread desired genetical material, although its use in buffalos still presents limitations, mainly the low embryo recovery rate. The corpus luteum (CL) is a tempo
Publicado em: 2008
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29. Expression of mRNA of the VEGF, Flt-1 and KDR in placentome, interplacentomal areas and gestational corpus luteum in different phases of pregnancy in cloned and non-cloned bovines / Expressão do mRNA do VEGF, FIt-1 e KDR no placentoma, região interplacentomal e corpo lúteo em diferentes fases gestacionais em bovinos clonados e não clonados
The VEGF is a specific endothelial mitogenic factor that promotes feto-maternal cell differentiation in placenta through binding to its receptors (Flt-1 and KDR). Their expression is controlled by autocrine and paracrine mechanisms that are associated to placenta development. The bovine placenta was used in this study as a model due to easiness of evaluation
Publicado em: 2006
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30. Comparative study of the VEGF system temporal distribution in the bovine and canine placenta / Estudo comparativo da distribuição temporal do sistema VEGF na placenta de cães e de bovinos
The VEGF family is known to be responsible for the angiogenesis increasing blood vessels number and permeability in the endometrial/placentary interface. A comparative study of VEGF system temporal distribution in canine and bovine placentas, which present very well described differences in structure and function, will contribute to better define the role of
Publicado em: 2006
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31. Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis
Vascular endothelial growth factor (VEGF) binding to the kinase domain receptor (KDR/FLK1 or VEGFR–2) mediates vascularization and tumor-induced angiogenesis. Since there is evidence that KDR plays an important role in tumor angiogenesis, we sought to identify peptides able to block the VEGF–KDR interaction. A phage epitope library was screened by affini
Oxford University Press.
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32. Tight genetic linkage between the kdr insecticide resistance trait and a voltage-sensitive sodium channel gene in the house fly.
The kdr insecticide resistance trait in the house fly, Musca domestica, confers resistance to the rapid paralysis (knockdown) and lethal effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and pyrethroids. Flies with the kdr trait exhibit reduced neuronal sensitivity to these compounds, which are known to act at voltage-sensitive sodium channels o
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33. Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA.
Vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR play important roles in physiological and pathological angiogenesis. Ribozymes that target the VEGF receptor mRNAs were developed and their biological activities in cell culture and an animal model were assessed. Ribozymes targeting Flt-1 or KDR mRNA sites reduced VEGF-induced prolifer
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34. Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells.
Vascular endothelial growth factor (VEGF) potently stimulates angiogenesis, whereas TNF-alpha has both pro- and anti-angiogenic activity. By measuring thymidine uptake, we found that TNF-alpha blocked a 2.3-fold increase in DNA synthesis induced by VEGF in human endothelial cells. To explore the possibility that the two interact to regulate endothelial cell
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35. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells
KDR/Flk-1 tyrosine kinase, one of the two vascular endothelial growth factor (VEGF) receptors, induces mitogenesis and differentiation of vascular endothelial cells. To understand the mechanisms underlying the VEGF-A-induced growth signaling pathway, we constructed a series of human KDR mutants and examined their biological properties. An in vitro kinase ass
Oxford University Press.
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36. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade.
Vascular endothelial growth factor (VEGF) is an angiogenic inducer that mediates its effects through two high affinity receptor tyrosine kinases, Flt-1 and KDR. Flt-1 is required for endothelial cell morphogenesis whereas KDR is involved primarily in mitogenesis. Flt-1 has an alternative ligand, placenta growth factor (PlGF). Both Flt-1 and KDR have seven im