Kala Azar
Mostrando 1-12 de 80 artigos, teses e dissertações.
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1. Visceral leishmaniasis mimicking systemic lupus erythematosus
Abstract Visceral leishmaniasis (VL), or kala-azar, a serious disease resulting from a systemic infection caused by a protozoan of the genus Leishmania, is potentially fatal to humans. According to data from Sistema de Informação de Agravos de Notificação (Brazil's Information System for Notifiable Diseases) from 2015 to 2016, 6,489 new cases were record
Rev. Soc. Bras. Med. Trop.. Publicado em: 21/02/2019
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2. Design of Novel N-Myristoyltransferase Inhibitors of Leishmania donovani Using Four-Dimensional Quantitative Structure-Activity Relationship Analysis
N-Myristoylation protein is catalyzed by N-myristoyltransferase (NMT), an essential target in Leishmania donovani, the causative agent of kala-azar. Four-dimensional quantitative structure-activity relationship (4D-QSAR) analysis was applied to a series of 77 Leishmania donovani NMT inhibitors. Then, three new compounds were proposed using QSAR models. In ad
J. Braz. Chem. Soc.. Publicado em: 2018-07
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3. Erratum: Para-kala-azar dermal leishmaniasis in a patient in Brazil: a case report
Rev. Soc. Bras. Med. Trop.. Publicado em: 07/06/2018
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4. Erratum: Para-kala-azar dermal leishmaniasis in a patient in Brazil: a case report
Rev. Soc. Bras. Med. Trop.. Publicado em: 07/06/2018
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5. Is Visceral Leishmaniasis the same in HIV-coinfected adults?
ABSTRACT Introduction: Visceral Leishmaniasis is the most severe form of disease caused by the Leishmania donovani complex, with significant morbidity and mortality in developing countries. Worse outcomes occur among HIV-positive individuals coinfected with Leishmania. It is unclear, however, if there are significant differences on presentation between Visc
Braz J Infect Dis. Publicado em: 2018-03
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6. Para-kala-azar dermal leishmaniasis in a patient in Brazil: a case report
Abstract Visceral leishmaniasis is common in Brazil and is caused by Leishmania (Leishmania) infantum/chagasi. Post-kala-azar dermal leishmaniasis frequently follows visceral leishmaniasis caused by L. donovani, and para-kala-azar dermal leishmaniasis refers to an uncommon presentation wherein it occurs simultaneously along with visceral leishmaniasis. While
Rev. Soc. Bras. Med. Trop.. Publicado em: 2018-02
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7. Predicting death from kala-azar: construction, development, and validation of a score set and accompanying software
Abstract INTRODUCTION Early identification of patients at higher risk of progressing to severe disease and death is crucial for implementing therapeutic and preventive measures; this could reduce the morbidity and mortality from kala-azar. We describe a score set composed of four scales in addition to software for quick assessment of the probability of dea
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-12
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8. Comparison of optical microscopy and quantitative polymerase chain reaction for estimating parasitaemia in patients with kala-azar and modelling infectiousness to the vector Lutzomyia longipalpis
Currently, the only method for identifying infective hosts with Leishmania infantum to the vector Lutzomyia longipalpis is xenodiagnosis. More recently, quantitative polymerase chain reaction (qPCR) has been used to model human reservoir competence by assuming that detection of parasite DNA indicates the presence of viable parasites for infecting vectors. Si
Mem. Inst. Oswaldo Cruz. Publicado em: 18/07/2016
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9. Post-kala-azar dermal Leishmaniasis in two different clinical contexts
AbstractIn Brazil, visceral Leishmaniasis is caused by Leishmania chagasi. The development of cutaneous lesions in visceral leishmaniasis patients has been described in two different clinical contexts. Patients with compromised immunity can develop skin lesions as a direct consequence of a current visceral disease. Equally, patients with a history of kala-az
An. Bras. Dermatol.. Publicado em: 2015-06
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10. Therapy with radio-attenuated vaccine in experimental murine visceral leishmaniasis showed enhanced T cell and inducible nitric oxide synthase levels, suppressed tumor growth factor-beta production with higher expression of some signaling molecules
Background:Visceral leishmaniasis (VL) or Kala-Azar (KA) is one of the most deadly forms of disease among all neglected tropical diseases. There are no satisfactory drugs or vaccine candidates available for this dreaded disease. Our previous studies showed promising therapeutic and prophylactic efficacy of the live, radio-attenuated parasites through intramu
Braz J Infect Dis. Publicado em: 2015-02
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11. Genes that encodes NAGT, MIF1 and MIF2 are not virulence factors for kala-azar caused by Leishmania infantum
IntroductionKala-azar is a disease resulting from infection by Leishmania donovani and Leishmania infantum. Most patients with the disease exhibit prolonged fever, wasting, anemia and hepatosplenomegaly without complications. However, some patients develop severe disease with hemorrhagic manifestations, bacterial infections, jaundice, and edema dyspnea, amon
Rev. Soc. Bras. Med. Trop.. Publicado em: 2014-10
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12. Kidney involvement in leishmaniasis—a review
Leishmaniasis is an infectious disease caused by protozoa of the genus Leishmania transmitted by insects of the genus Lutzomyia sp. or Phlebotomus sp. The main syndromes are cutaneous leishmaniasis, mucocutaneous leishmaniasis, visceral leishmaniasis (kala-azar) and post-kala-azar dermal leishmaniasis. This article reviews kidney involvement in cutaneous and
Braz J Infect Dis. Publicado em: 2014-08