Jak2 V617f
Mostrando 25-31 de 31 artigos, teses e dissertações.
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25. JAK2 V617F prevalence in Brazilian patients with polycythemia vera, idiopathic myelofibrosis and essential thrombocythemia
Polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF) are myeloproliferative disorders (MPD) that arise from the clonal proliferation of a pluripotent hematopoietic progenitor, leading to the overproduction of one or more myeloid lineages. Recently, a specific mutation in the JAK2 gene, which encodes a tyrosine kinase, has
Genetics and Molecular Biology. Publicado em: 2007-03
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26. Expressão genica global e estudo do gene JUNB em policitemia vera / Global gene expression and study of the JUNB gene in polycythemia
Polycythemia vera (PV) is a chronic myeloproliferative disorder that arises through clonal proliferation of multipotent hematopoietic progenitors. PV patients present bone marrow trilineage expansion, leading to increased production of mature red cells, granulocytes and platelets. Important PV features are elevated red cell mass, despite normal or subnormal
Publicado em: 2007
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27. Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F
The JAK2 mutation JAK2V617F is found frequently in patients with myeloproliferative disorders (MPD) and transforms hematopoietic cells to cytokine-independent proliferation when expressed with specific cytokine receptors. The Src homology 2 (SH2) and pleckstrin homology (PH) domain-containing adaptor protein Lnk (SH2B3) is a negative regulator of hematopoiet
The Society for Leukocyte Biology.
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28. The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome
Patients with myeloproliferative disorders are at a high risk of developing thrombotic events. Several investigators have hypothesized that endothelial cell (EC) abnormalities might contribute to this prothrombotic state. Budd-Chiari syndrome (BCS) and portal vein thrombosis have been reported to be associated with JAK2V617F-positive hematopoiesis. We explor
American Society of Hematology.
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29. Germline and somatic JAK2 mutations and susceptibility to chronic myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are a group of closely related stem-cell-derived clonal proliferative diseases. Most cases are sporadic but first-degree relatives of MPN patients have a five- to seven-fold increased risk for developing an MPN. The tumors of most patients carry a mutation in the Janus kinase 2 gene (JAK2V617F). Recently, three groups have
BioMed Central.
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30. The JAK2 V617F mutation in Philadelphia‐negative chronic myeloproliferative disorders
BMJ Group.
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31. BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair
Intracellular oxidative stress in cells transformed by the BCR-ABL oncogene is associated with increased DNA double-strand breaks. Imprecise repair of these breaks can result in the accumulation of mutations, leading to therapy-related drug resistance and disease progression. Using several BCR-ABL model systems, we found that BCR-ABL specifically promotes th
American Society of Hematology.