Isoxazoles
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Synthesis of 3,5-Diarylisoxazole Derivatives and Evaluation of in vitro Trypanocidal Activity
Chagas disease is included in the neglected tropical diseases list and is endemic to 21 Latin American countries. The two drugs currently available for treating Chagas disease are nifurtimox and benznidazole and both result in many significant side effects. The study describes the synthesis and biological evaluation of 3,5-disubstituted isoxazoles. Isoxazole
J. Braz. Chem. Soc.. Publicado em: 2018-02
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2. NH-PIRAZÓIS E ISOXAZÓIS: SÍNTESE MECANICAMENTE ATIVADA POR GRINDING / NH-PYRAZOLES AND ISOXAZOLES: SYNTHESIS MECHANICALLY ACTIVATED BY GRINDING
The synthesis of twelve NH-pyrazoles from the cyclocondensation reaction of β-dimethylaminovinylketones ([R1C(O)C(R2)=CHN(Me)2], where R1 = Me, C6H5, 3- MeO-C6H4, 4-Me-C6H4, 4-MeO-C6H4, 4-F-C6H4, 4-Cl-C6H4, 4-Br-C6H4, 4-O2N-C6H4, fur-2-il, tien-2-il; R2 = H, 2-MeO-C6H4 and R1, R2 = -(CH2)3C(O)- with hydrazine sulfate is reported. In this work, it was al
Publicado em: 2010
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3. Aplicação de α-oxoceteno ditiocetais em síntese orgânica
The synthesis and reactivity of α-oxoketenes dithioacetals (S,S-acetals), general structure [(R¹C=OC(R²)=C(SR³)(SR4)], are reported. We also showed the application of S,S acetals as synthons for efficient synthesis of isoxazoles, pyrazoles, indazoles, thiophenes, dithiol thiones, pyridines, pyrimidines and other heterocycles. This work aims to review the
Química Nova. Publicado em: 2010
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4. Tolerância de híbridos de milho ao herbicida isoxaflutole
Objetivou-se com este trabalho avaliar a tolerância de híbridos de milho ao isoxaflutole e relacionar estudos de seletividade desse herbicida conduzidos em casa de vegetação com estudos desenvolvidos em campo. Em casa de vegetação, o experimento foi conduzido no delineamento de blocos ao acaso, num arranjo fatorial de 23 x 3, sendo o primeiro fator con
Planta Daninha. Publicado em: 2008
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5. β-ENAMINONAS, 5-HIDRÓXI-4,5-DIIDROPIRAZÓIS E 5- HIDRÓXI-4,5-DIIDROISOXAZÓIS HALOMETILSUBSTITUÍDOS: ESTUDO MOLECULAR POR DIFRAÇÃO DE RAIOS-X / β-ENAMINONES, 5-HYDROXY-4,5-DIHYDROPYRAZOLE AND 5-HYDROXY-4,5-DIHYDROISOXAZOLE HALOMETHYL SUBSTITUTED: MOLECULAR STUDY BY X-RAY DIFFRACTOMETRY
The molecular study by X-ray diffraction of β-aminovinyl ketones [R3C(O)CH=C(R1)N(R4R5), onde R3 = CF3, CCl3, CHCl2; R1 = H, Me; R4 = H; R5 = benzyl, Ph, 5-methylisoxazol-3-yl; R4, R5 = -(CH2)4-, -(CH2)2O(CH2)2-], methyl 5- hydroxy-5-trihalomethyl-4,5-dihydro-1H-pyrazole-1-carboxylate [3-(R1), 4-(R2), and 5- (R3) substituted, where R1 = H, Me; R2 = H, M
Publicado em: 2008
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6. SULFOXIMIDOVINIL TRIFLUORMETIL CETONAS. OBTENÇÃO E APLICAÇÃO NA SÍNTESE DE AZÓIS E AZINAS DERIVADAS / SULFOXIMIDOVINIL TRIFLUORMETIL CETONAS. OBTENÇÃO E APLICAÇÃO NA SÍNTESE DE AZÓIS E AZINAS DERIVADAS / SULFOXIMIDOVINYL TRIFLUOROMETHYL KETONES. PREPARATION AND APPLICATION IN THE SYNTHESIS OF AZOLES AND AZINES DERIVATIVES / SULFOXIMIDOVINYL TRIFLUOROMETHYL KETONES. PREPARATION AND APPLICATION IN THE SYNTHESIS OF AZOLES AND AZINES DERIVATIVES
This work describes the synthesis of a new series of 4-alkyl(aryl)-4-tetramethylenesulfoximide-1,1,1-trifluorobut-3-en-2-ones (5a-k) by the O,N-exchange reactions of ketones (1a-k) [CF3C(O)CH=CR1R, where R = OMe, OEt; R1 = H, Me, Ph, 4-MePh, 4-MeOPh, 4-BrPh, 4-ClPh, 4-FPh, 4-NO2Ph, 4,4-Bifenil, 1-Naftil] with tetramethylenesulfoximide (4) in absence of solve
Publicado em: 2007
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7. AVALIAÇÃO DA ATIVIDADE ANTIMICROBIANA DE DERIVADOS ISOXAZÓIS / ANTIMICROBIAL ACTIVITY EVALUATED OF ISOXAZOLES DERIVATIVES
Isoxazoles compounds have been showing a great variety of pharmacological activities. Such activities might be increased by the presence of halomethyl-substitute groups in isoxazoles. This work shows the synthesis of the series of 5-trichloromethyl-5-hydroxi-4,5- dihydroisoxazoles 2a-o, 5-carboxy-isoxazoles 3a-o e 3-aryl-5- trichloro(fluoro)methylisoxazoles,
Publicado em: 2005
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8. REAÇÃO DE β-DIMETILAMINOVINIL CETONAS COM HIDROXILAMINA: REGIOQUÍMICA DE FORMAÇÃO DE 4,5-DIIDROISOXAZÓIS E DE ISOXAZÓIS / REGIOCHEMISTRY STUDY OF THE ISOXAZOLE FORMATION FROM THE REACTION OF β-DIMETHYLAMINOVINYL KETONES AND HYDROXYLAMINE
Este trabalho descreve o estudo da regioquímica de formação de uma série de isoxazóis aril-, heteroaril- e haloalquil substituídos, a partir da reação de β- dimetilaminovinil cetonas e hidroxilamina. O precursor β-dimetilaminovinil cetona foi obtido a partir da reação de condensação de N,N-dimetilformamida dimetil acetal e a cetona subs
Publicado em: 2005