Isolated Myocyte
Mostrando 1-12 de 78 artigos, teses e dissertações.
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1. LOW-INTENSITY ENDURANCE TRAINING AND RIGHT VENTRICULAR MYOCYTES OF HYPERTENSIVE RATS
RESUMO Introdução As adaptações estruturais e mecânicas de miócitos do ventrículo direito (VD) em resposta à hipertensão associada ao treinamento aeróbio de baixa intensidade (TABI) não foram estudadas em modelos experimentais de ratos. Objetivo Determinar os efeitos do TABI sobre as propriedades estruturais e mecânicas de miócitos do VD em
Rev Bras Med Esporte. Publicado em: 01/07/2019
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2. Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats
OBJECTIVES: The present study was performed to investigate 1) whether aerobic exercise training prior to myocardial infarction would prevent cardiac dysfunction and structural deterioration and 2) whether the potential cardiac benefits of aerobic exercise training would be associated with preserved morphological and contractile properties of cardiomyocytes
Clinics. Publicado em: 2013-04
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3. Exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes obtained from spontaneously hypertensive rats
We determined the effects of exercise training and detraining on the morphological and mechanical properties of left ventricular myocytes in 4-month-old spontaneously hypertensive rats (SHR) randomly divided into the following groups: sedentary for 8 weeks (SED-8), sedentary for 12 weeks (SED-12), treadmill-running trained for 8 weeks (TRA, 16 m/min, 60 min/
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-11
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4. Modelo experimental e intrumentação para estudo da função do reticulo sarcoplasmatico no transporte de Ca 2+ no coração / Experimental model and instrumentation for the study of sarcoplasmic reticulum Ca 2+ transport in the heart
The goal of this work was to develop an instrument for simultaneous measurement of cell shortening and cytosolic Ca2+ concentration ([Ca2+]i), by using the fluorescent Ca2+ indicator fluo-3. The instrument was applied to study the uptake of cytosolic Ca2+ by the sarcoplasmic reticulum (RS) Ca2+- ATPase (SERCA, the main transporter responsible for cell relaxa
Publicado em: 2007
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5. Contractile activity and calcium cycling in ventricular myocytes exposed to NaCI hyperosmotic solution / Atividade contratil e mobilização de calcio em miocitos ventriculares na presença de solução hiperosmotica de NaCI
A infusão intravenosa de solução hiperosmótica de NaCI tem se mostrado eficaz como tratamento único para a condição de choque hemorrágico, mas o conhecimento de seus efeitos sobre o coração ainda é limitado. Neste trabalho, desenvolvemos instrumentação para registro de encurtamento celular e investigamos o efeito direto de soluções hiperosmót
Publicado em: 2005
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6. Inhibition of the sarcoplasmic reticulum Ca2+ pump with thapsigargin to estimate the contribution of Na+-Ca2+ exchange to ventricular myocyte relaxation
Relaxation in the mammalian ventricle is initiated by Ca2+ removal from the cytosol, which is performed by three main transport systems: sarcoplasmic reticulum Ca2+-ATPase (SR-A), Na+-Ca2+ exchanger (NCX) and the so-called slow mechanisms (sarcolemmal Ca2+-ATPase and mitochondrial Ca2+ uptake). To estimate the relative contribution of each system to twitch r
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-12
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7. Stretch-induced atriopeptin secretion in the isolated rat myocyte and its negative modulation by calcium.
Cellular mechanism(s) regulating atriopeptin secretion and processing by the atrial myocyte are currently unknown. Osmotic stretch of isolated atrial myocytes as well as potassium chloride depolarization were potent stimuli of atriopeptin secretion. Release was potentiated by buffering either extracellular calcium with EGTA or intracellular calcium with the
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8. Neutrophil adherence to isolated adult cardiac myocytes. Induction by cardiac lymph collected during ischemia and reperfusion.
Canine neutrophils can be induced to adhere in vitro to isolated adult cardiac myocytes by stimulation of the neutrophils with chemotactic factors such as zymosan-activated serum (ZAS) only if the myocytes have been previously exposed to cytokines such as interleukin 1 (IL-1) or tumor necrosis factor-alpha. These cytokines induce synthesis and surface expres
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9. Comparison of intracellular pH transients in single ventricular myocytes and isolated ventricular muscle of guinea-pig.
1. Intracellular pH was recorded (double-barrelled pH-selective microelectrodes) in single ventricular myocytes and whole papillary muscles isolated from guinea-pig heart. Both preparations were acid-loaded by various manoeuvres (addition and removal of external NH4Cl or CO2) in order that a comparison could be made of the size and speed of intracellular pH
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10. Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.
To define the mechanism(s) responsible for the negative inotropic effects of tumor necrosis factor-alpha (TNF alpha) in the adult heart, we examined the functional effects of TNF alpha in the intact left ventricle and the isolated adult cardiac myocyte. Studies in both the ventricle and the isolated adult cardiac myocyte showed that TNF alpha exerted a conce
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11. The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta.
Inducible nitric oxide (NO) produced by macrophages is cytotoxic to invading organisms and has an important role in host defense. Recent studies have demonstrated inducible NO production within the heart, and that cytokine-induced NO mediates alterations in cardiac contractility, but the cytotoxic potential of nitric oxide with respect to the heart has not b
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12. Measurement of Cardiac Mechanical Function in Isolated Ventricular Myocytes from Rats and Mice by Computerized Video-Based Imaging
Isolated adult cardiac ventricular myocytes have been a useful model for cardiovascular research for more than 20 years. With the recent advances in cellular physiology and transgenic techniques, direct measurement of isolated ventricular myocyte mechanics is becoming an increasingly important technique in cardiac physiology that provides fundamental informa
Biological Procedures Online.