Intramolecular Flexibility
Mostrando 13-15 de 15 artigos, teses e dissertações.
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13. Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase.
Processing of the hepatitis C virus polyprotein is accomplished by a series of cotranslational and posttranslational cleavages mediated by host cell signalases and two virally encoded proteinases. Of these the NS3 proteinase is essential for processing at the NS3/4A, NS4A/4B, NS4B/5A, and NS5A/5B junctions. Processing between NS3 and NS4A occurs in cis, impl
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14. Nonnucleoside Inhibitor Binding Affects the Interactions of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase with DNA
Site-directed photoaffinity cross-linking experiments were performed by using human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutants with unique cysteine residues at several positions (i.e., positions 65, 67, 70, and 74) in the fingers subdomain of the p66 subunit. Since neither the introduction of the unique cysteine residues into th
American Society for Microbiology.
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15. Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity
The prototypical fibroblast growth factor receptor (FGFR) extracellular domain consists of three Ig domains (D1–D3) of which the two membrane-proximal D2 and D3 domains and the interconnecting D2–D3 linker bear the determinants of ligand binding and specificity. In contrast, D1 and the D1–D2 linker are thought to play autoinhibitory roles in FGFR regul
National Academy of Sciences.