Intracellular Pathways
Mostrando 13-24 de 1075 artigos, teses e dissertações.
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13. Study of Vaccinia and Cowpox viruses' replication in Rac1-N17 dominant-negative cells
Interfering with cellular signal transduction pathways is a common strategy used by many viruses to create a propitious intracellular environment for an efficient replication. Our group has been studying cellular signalling pathways activated by the orthopoxviruses Vaccinia (VACV) and Cowpox (CPXV) and their significance to viral replication. In the present
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-08
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14. The acute effects of strength, endurance and concurrent exercises on the Akt/mTOR/p70S6K1 and AMPK signaling pathway responses in rat skeletal muscle
The activation of competing intracellular pathways has been proposed to explain the reduced training adaptations after concurrent strength and endurance exercises (CE). The present study investigated the acute effects of CE, strength exercises (SE), and endurance exercises (EE) on phosphorylated/total ratios of selected AMPK and Akt/mTOR/p70S6K1 pathway prot
Braz J Med Biol Res. Publicado em: 19/04/2013
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15. Vias intracelulares da ação do Sildenafil no diabetes insipidus induzido pelo lítio / Sildenafil action in lithium-induced NDI: intracellular pathway
Patients taking lithium to treat bipolar disorder often present polyuria and urinary concentrating defect. In addition, lithium-treated animals present lower cyclic adenosine monophosphate production in response to vasopressin. Sildenafil (Sil), a phosphodiesterase 5 (PDE5) inhibitor, elevates intracellular cyclic guanosine monophosphate (cGMP) levels, leadi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/06/2012
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16. A eritropoietina protege a função sistólica de corações neonatais submetidos a isquemia e reperfusão regional : trabalho experimental / Erythropoietin protects the systolic function of neonatal hearts against ischemiareperfusion injury
Background: The effect of erythropoietin (EPOT) on neonatal hearts is not well understood. The current hypothesis is that erythropoietin has protective effects against ischemia-reperfusion when administered prior to ischemia induction. Methods: Systolic and diastolic indices, as well as the Akt and extracellular regulated kinase (ERK) signaling pathways, wer
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/04/2012
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17. The role of Ca2+/calmodulin-dependent protein kinase II and calcineurin in TNF-α-induced myocardial hypertrophy
We investigated whether Ca2+/calmodulin-dependent kinase II (CaMKII) and calcineurin (CaN) are involved in myocardial hypertrophy induced by tumor necrosis factor α (TNF-α). The cardiomyocytes of neonatal Wistar rats (1-2 days old) were cultured and stimulated by TNF-α (100 μg/L), and Ca2+ signal transduction was blocked by several antagonists, including
Braz J Med Biol Res. Publicado em: 2012-11
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18. The sodium pump controls the frequency of action-potential-induced calcium oscillations
Calcium plays a significant role in a number of cellular processes, like muscle contraction, gene expression, synaptic plasticity, signal transduction, but the significance of calcium oscillations (CaOs) is not yet completely understood in most of the cell types. It is a widely accepted fact that CaOs are a frequency encoded signal that allows a cell to use
Comput. Appl. Math.. Publicado em: 2012
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19. Influência das citocinas IL-10, TGF-β1 e IFN-γ na susceptibilidade de células trofoblásticas humanas (linhagem BeWo) e células epiteliais uterinas humanas (linhagem HeLa) à infecção por Toxoplasma gondii: papel na expressão de ICAM-1, na adesão do parasito à célula hospedeira e vias de sinalização intracelulares ativadas
Toxoplasma gondii é um protozoário parasito intracelular obrigatório capaz de infectar uma diversidade de células, incluindo células trofoblásticas. Estudos prévios demonstraram que interleucina (IL)-10, fator transformador de crescimento (TGF)-β1 e interferon (IFN)-γ são importantes citocinas envolvidas na susceptibilidade de células trof
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/11/2011
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20. Vias de sinalização intracelular envolvidas no efeito proliferativo de relaxina em células de sertoli / Intracelular signaling pathways involved in the proliferative effect of relaxin in rat Sertoli cells
Relaxin is an insulin-related peptide that activates the G-protein coupled receptor RXFP1. Although relaxin plays an important role in female reproduction its physiological role in the male reproductive system is still unclear. We have previously demonstrated that relaxin and RXFP1 are expressed in testis (FILONZI et al., 2007; CARDOSO et al., 2010). Both re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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21. Fusão Homotípica e Heterotípica entre Vacúolos Parasitóforos de Leishmania spp / Homotypic and Heterotypic Fusion between Leishmania spp. Parasitophorous Vacuoles
Most non-viral intracellular pathogens gain entrance into human and animal host cells by classic or modifIed phagocytosis and are thus lodged in phagosomes which they may or not continue to occupy in the course of infection. Their survival and multiplication within host cells depend on modulation of the compositional and functional phenotypes of the phagosom
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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22. Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common human life-threatening monogenic disorders. The disease is characterized by bilateral, progressive renal cystogenesis and cyst and kidney enlargement, often leading to end-stage renal disease, and may include extrarenal manifestations. ADPKD is caused by mutation in one of two gen
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-07
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23. Concanavalina-A aumenta a produção de TNF-a, a atividade de receptores de manose e a capacidade de destruir Candida por macrófagos peritoneais
Recognition of Candida albicans by Toll-like receptors and lectin receptors on the phagocytic cells activates intracellular signaling pathways that trigger production of proinflammatory cytokines that are critical for host defence. Th1-response provide control of fungal infectivity by increasing the expression of receptors that acts as sensors for infection
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2010
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24. Análise bioquímica inicial do proteassoma em populações do Trypanosoma cruzi com diferentes fenótipos de resistência ao benzonidazol
Differences in susceptibility to benznidazole (Bz) and nifurtimox (NFX) among populations of Trypanosoma cruzi may explain, at least in part, the differences in efficacy of treatment of Chagas disease. The proteasome has an important role in the degradation of normal proteins, damaged, mutated, or denatured, including the degradation of regulatory proteins o
Publicado em: 2010