Intracellular Ca2 Handling
Mostrando 1-12 de 30 artigos, teses e dissertações.
-
1. Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity
Obesity is often associated with changes in cardiac function; however, the mechanisms responsible for functional abnormalities have not yet been fully clarified. Considering the lack of information regarding high-saturated-fat diet-induced obesity, heart function, and the proteins involved in myocardial calcium (Ca2+) handling, the aim of this study was to t
Braz J Med Biol Res. Publicado em: 27/05/2019
-
2. Mibefradil reduces blood glucose concentration in db/db mice
OBJECTIVE: Numerous recent studies suggest that abnormal intracellular calcium concentration ([Ca2+]i) is a common defect in diabetic animal models and patients. Abnormal calcium handling is an important mechanism in the defective pancreatic β-cell function in type 2 diabetes. T-type Ca2+ channel antagonists lower blood glucose in type 2 diabetes, but the
Clinics. Publicado em: 2014-01
-
3. Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors
The regulatory function of α1B-adrenoceptors in mammalian heart homeostasis is controversial. The objective of the present study was to characterize the expression/activity of key proteins implicated in cardiac calcium handling (Na+/K+-ATPase and Ca2+-ATPases) and growth (ERK1/2, JNK1/2 and p38) in mice with cardiac-selective overexpression of constitutivel
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-05
-
4. Efeito do treinamento físico na expressão de proteínas que transportam Ca2+ e participam do sistema proteolítico dependente de Ca2+ na musculatura esquelética em modelo experimental de insuficiência cardíaca / Effect of exercise training on Ca2+ handling and Ca2+ induced proteolysis in skeletal musculature of heart failure experimental model
Recentemente foi demonstrado que na insuficiência cardíaca (IC), a via final das doenças circulatórias e a maior causa de internação em idosos no Brasil, os danos morfo-funcionais da musculatura esquelética representam um preditor independente de mortalidade. Por outro lado, é conhecido que o treinamento físico aeróbico previne o aparecimento desse
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/03/2009
-
5. Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
The pancreatic acinar cell is a classical model for studies of secretion and signal transduction mechanisms. Because of the extensive endoplasmic reticulum and the large granular compartment, it has been possible - by direct measurements - to obtain considerable insights into intracellular Ca2+ handling under both normal and pathological conditions. Recent s
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-01
-
6. Obesity induces upregulation of genes involved in myocardial Ca2+ handling
Obesity is a complex multifactorial disorder that is often associated with cardiovascular diseases. Research on experimental models has suggested that cardiac dysfunction in obesity might be related to alterations in myocardial intracellular calcium (Ca2+) handling. However, information about the expression of Ca2+-related genes that lead to this abnormality
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-07
-
7. The importance of the Thr17 residue of phospholamban as a phosphorylation site under physiological and pathological conditions
The sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) is under the control of an SR protein named phospholamban (PLN). Dephosphorylated PLN inhibits SERCA2a, whereas phosphorylation of PLN at either the Ser16 site by PKA or the Thr17 site by CaMKII reverses this inhibition, thus increasing SERCA2a activity and the rate of Ca2+ uptake by the SR. This leads to
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-05
-
8. Ryanodine Receptor Regulation by Intramolecular Interaction between Cytoplasmic and Transmembrane Domains
Ryanodine receptors (RyR) function as Ca2+ channels that regulate Ca2+ release from intracellular stores to control a diverse array of cellular processes. The massive cytoplasmic domain of RyR is believed to be responsible for regulating channel function. We investigated interaction between the transmembrane Ca2+-releasing pore and a panel of cytoplasmic dom
The American Society for Cell Biology.
-
9. Serotonin increases intracellular Ca2+ transients in voltage-clamped sensory neurons of Aplysia californica.
Noxious stimulation of the tail of Aplysia californica produces behavioral sensitization; it enhances several related defensive reflexes. This reflex enhancement involves heterosynaptic facilitation of transmitter release from sensory neurons of the reflex. The facilitation is stimulated by serotonin (5-HT) and involves suppression of a 5-HT-sensitive K+ cur
-
10. Role of intracellular sodium in the regulation of intracellular calcium and contractility. Effects of DPI 201-106 on excitation-contraction coupling in human ventricular myocardium.
Experiments were performed to investigate the mechanism of action of DPI 201-106 on human heart muscle. In both control and myopathic muscles, DPI produced concentration-dependent increases in action potential duration, resting muscle tension, peak isometric tension, and duration of isometric tension. These changes were associated with increases in resting i
-
11. Diminished post-rest potentiation of contractile force in human dilated cardiomyopathy. Functional evidence for alterations in intracellular Ca2+ handling.
Post-rest contractile behavior of isolated myocardium indicates the capacity of the sarcoplasmic reticulum (SR) to store and release Ca2+. We investigated post-rest behavior in isolated muscle strips from nonfailing (NF) and endstage failing (dilated cardiomyopathy [DCM]) human hearts. At a basal stimulation frequency of 1 Hz, contractile parameters of the f
-
12. Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones.
1. Impaired intracellular Ca2+ concentration ([Ca2+]i) regulation may underlie alterations in neuronal function during hypoxia or hypoglycaemia and may initiate cell damage. We have used the Ca2(+)-sensitive fluorophore, Fura-2, to study the regulation of [Ca2+]i in neurones isolated from mouse dorsal root ganglia. Mean resting [Ca2+]i was 163 +/- 11 nM (mea