Interrogation
Mostrando 37-48 de 56 artigos, teses e dissertações.
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37. Folter Arzt: interrogation of prisoners in Austria in 1773
The Royal Society of Medicine.
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38. Interrogation of prisoners after 2003: the role of health professionals
The Royal Society of Medicine.
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39. Advances in fetal echocardiography.
Fetal echocardiography is the primary modality for defining and evaluating fetal cardiac status and requires detailed analysis of the cardiac anatomy from numerous views and Doppler interrogation of the intracardiac structures, great vessels, and umbilical artery. Referrals for fetal echocardiography are determined by fetal, maternal, or familial risk factor
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40. Hepatitis C Virus Genotyping: Interrogation of the 5′ Untranslated Region Cannot Accurately Distinguish Genotypes 1a and 1b
Although the 5′ untranslated region (5′ UTR) is the most conserved region of the hepatitis C virus (HCV) genome, it has been suggested that interrogation of this region is sufficient for determination of the HCV genotype. We compared two methods of determination of the HCV genotype: (i) direct sequencing of the DNA of the NS-5b region and (ii) reverse li
American Society for Microbiology.
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41. PRINTS and its automatic supplement, prePRINTS
The PRINTS database houses a collection of protein fingerprints. These may be used to assign uncharacterised sequences to known families and hence to infer tentative functions. The September 2002 release (version 36.0) includes 1800 fingerprints, encoding ∼11 000 motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. In
Oxford University Press.
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42. Brassica ASTRA: an integrated database for Brassica genomic research
Brassica ASTRA is a public database for genomic information on Brassica species. The database incorporates expressed sequences with Swiss-Prot and GenBank comparative sequence annotation as well as secondary Gene Ontology (GO) annotation derived from the comparison with Arabidopsis TAIR GO annotations. Simple sequence repeat molecular markers are identified
Oxford University Press.
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43. LNA-enhanced detection of single nucleotide polymorphisms in the apolipoprotein E
Genotyping of single nucleotide polymorphisms (SNPs) in large populations presents a great challenge, especially if the SNPs are embedded in GC-rich regions, such as the codon 112 SNP in the human apolipoprotein E (apoE). In the present study, we have used immobilized locked nucleic acid (LNA) capture probes combined with LNA-enhancer oligonucleotides to obt
Oxford University Press.
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44. Purification and Mechanism of Human Aldehyde Oxidase Expressed in Escherichia coli
Human aldehyde oxidase 1 (AOX1) has been subcloned into a vector suitable for expression in Escherichia coli, and the protein has been expressed. The resulting protein is active, with sulfur being incorporated in the molybdopterin cofactor. Expression levels are modest, but 1 liter of cells supplies enough protein for both biochemical and kinetic characteriz
The American Society for Pharmacology and Experimental Therapeutics.
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45. Genome-scale functional profiling of the mammalian AP-1 signaling pathway
Large-scale functional genomics approaches are fundamental to the characterization of mammalian transcriptomes annotated by genome sequencing projects. Although current high-throughput strategies systematically survey either transcriptional or biochemical networks, analogous genome-scale investigations that analyze gene function in mammalian cells have yet t
National Academy of Sciences.
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46. Allergenicity of Piperazine: A Study in Environmental Aetiology
This paper reports an apparent biological difference between two otherwise identical preparations of piperazine hexahydrate. It reports the cutaneous irritancy and allergenicity of this substance and records the effect of environmental temperature on those properties, particularly the former. Finally, it reports severe, delayed asthma-like response to pipera
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47. Production of cyclic peptides and proteins in vivo
Combinatorial libraries of synthetic and natural products are an important source of molecular information for the interrogation of biological targets. Methods for the intracellular production of libraries of small, stable molecules would be a valuable addition to existing library technologies by combining the discovery potential inherent in small molecules
The National Academy of Sciences.
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48. Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA
We report a strategy for the reagentless transduction of DNA hybridization into a readily detectable electrochemical signal by means of a conformational change analogous to the optical molecular beacon approach. The strategy involves an electroactive, ferrocene-tagged DNA stem–loop structure that self-assembles onto a gold electrode by means of facile
National Academy of Sciences.