Interleukin 1 Receptor Antagonist
Mostrando 1-12 de 168 artigos, teses e dissertações.
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1. Correlation between the cytokine profile and anticongestive medication in patients with chronic chagasic cardiopathy
Abstract INTRODUCTION: Chronic chagasic cardiopathy (CCC) is essentially a dilated cardiomyopathy in which a subacute, but constant chronic inflammatory process causes progressive destruction of the heart tissue. The action of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and anti-inflammatory cytokines,
Rev. Soc. Bras. Med. Trop.. Publicado em: 02/12/2019
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2. Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia
We evaluated the impact of postprandial glycemia on blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in non-diabetic patients with symptoms suggesting reactive hypoglycemia. Eleven patients with clinical symptoms suggesting reactive hypoglycemia received an oral glucose solution (75 g) Blood was collected
Braz J Med Biol Res. Publicado em: 11/07/2016
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3. Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis
Dengue virus (DENV) and parvovirus B19 (B19V) infections are acute exanthematic febrile illnesses that are not easily differentiated on clinical grounds and affect the paediatric population. Patients with these acute exanthematic diseases were studied. Fever was more frequent in DENV than in B19V-infected patients. Arthritis/arthralgias with DENV infection w
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-02
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4. O polimorfismo do antagonista do receptor da interleucina-1 (IL1RN) como fator contribuinte para gravidade da cardite reumática em brasileiros / Interleukin-1 receptor antagonist gene (IL1RN) polymorphism as a contributing factor for the severity of rheumatic carditis in a brazilian cohort
A febre reumática (FR) é uma doença imuno-mediada, na qual citoquinas pró-inflamatórias têm um importante papel. Uma produção exacerbada de interleucina-1 (IL-1) parece ser um evento precoce entre as anormalidades imunológicas observadas na FR. O antagonista do receptor de IL-1 (IL1-RA) é um inibidor competitivo endógeno do receptor da IL-1. A raz
Publicado em: 2009
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5. Estresse oxidativo em camundongos knockout para o receptor de LDL : papel dos substratos redutores de NADP+ mitocondrial e dos niveis de Ca POT.2+ intracelular / Oxidative stress in LDL receptor knockout mice : role of NADP+ linked substrates and intracellular Ca POT.2+ levels
In this work, oxidative stress in liver mitochondria isolated from LDLr-/- mice was further characterized by showing a lower mitochondrial isocitrate content, lower matochondrial GSH/GSSG ratio and a higher liver content of protein carbonyls as compared to control mice. The higher rate of ROS production in LDLr -/- mitochondria was also prevented by the pres
Publicado em: 2008
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6. Estudo da homeostase dos mediadores pró-inflamatórios e antiinflamatórios na sepse neonatal / A Study of the homeostasis of the pro-inflammatory and anti-inflammatory mediators in neonatal sepsis
Objectives - To evaluate the utility of the pro-inflammatory mediators (TNF-alfa, IL1-beta, and IL-6), the anti-inflammatory mediators (IL-10 and IL-1Ra) and C-Reactive Protein (CRP) for the diagnosis of neonatal sepsis; to verify whether the isolated seric values or the relation between IL-6 and IL-1Ra have predictive values for severity regarding the clini
Publicado em: 2008
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7. Evaluation of the anti-inflammatory effects of the interleukin-1 receptor antagonist protein in equine synovial fluid using flow cytometric techniques / Avaliação dos efeitos antiinflamatórios da proteína antagonista de receptor de interleucina - 1 (IRAP) por citometria de fluxo em líquido sinovial de eqüino
Joint disease in horses, specifically osteoarthritis, is one of the most prevalent and debilitating illnesses affecting equine industry and for this reason continued research and improvements in therapeutics are needed. Osteoarthritis is a degenerative disease that can be triggered by a number of factors and where ultimately all articular tissues are affecte
Publicado em: 2007
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8. Study of the Antinociceptive activity of Thalidomide, Pentoxifillyne and Chlorpromazine in Experimental Models / Avaliação da atividade antinociceptiva da talidomida, pentoxifilina e clorpromazina em modelos experimentais.
The release of cyclo-oxygenase products and sympathomimetic amines, the final mediators of inflammatory pain, is preceded by the generation of pro-inflammatory and nociceptive cytokines by resident cells. Recently drugs such as thalidomide (TALD), pentoxifylline (PTX) and chlorpromazine (CLP), despite of other effects, have been associated with immunomodulat
Publicado em: 2003
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9. An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance.
In this report, administration of a recombinant interleukin-1 receptor antagonist protein to mice was found to inhibit induction of colony-stimulating factor as well as induction of early endotoxin tolerance by lipopolysaccharide. These findings provide direct evidence that interleukin-1 is an intermediate in these two lipopolysaccharide-induced phenomena.
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10. Evidence supporting a role for endogenous vasopressin in fever suppression in the rat.
1. Infusion of human purified interleukin-1 into a lateral cerebral ventricle of the rat evoked a rise in core temperature which was abolished by heating the interleukin-1. 2. When the intracerebroventricular infusion of interleukin-1 was preceded by a bilateral injection of saline into the ventral septal area, the resulting febrile response was not differen
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11. Conversion of the interleukin 1 receptor antagonist into an agonist by site-specific mutagenesis.
Interleukin 1 (IL-1) receptor antagonist (IL-1ra) is a naturally occurring protein that binds to the IL-1 receptor present on T cells, fibroblasts, and other cell types and acts to block IL-1-induced responses. IL-1ra is a pure antagonist and has no agonist activity in in vitro or in vivo systems. By site-specific mutagenesis, an analog of IL-1ra was created
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12. Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice.
Interleukin 1 receptor antagonist (IL-1ra) is a cytokine whose only known action is competitive inhibition of the binding of interleukin 1 (IL-1) to its receptor. To investigate the physiological roles of endogenously produced IL-1ra, we generated mice that either lack IL-1ra or overproduce it under control of the endogenous promoter. Mice lacking IL-1ra hav