Interaction With Liposomes
Mostrando 1-12 de 138 artigos, teses e dissertações.
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1. Interaction study between vancomycin and liposomes containing natural compounds against methicillin-resistant Staphylococcus aureus clinical isolates
ABSTRACT The treatment of infections caused by resistant microorganisms is limited, and vancomycin (VAN) treatment failures for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia are not uncommon, even when MRSA clinical isolates are susceptible to VAN. Thus, this study proposed the association of VAN with usnic acid and β-lapachone encapsulated
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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2. Effects of the encapsulation of usnic acid into liposomes and interactions with antituberculous agents against multidrug-resistant tuberculosis clinical isolates
Mycobacterium tuberculosis (Mtb) has acquired resistance and consequently the antibiotic therapeutic options available against this microorganism are limited. In this scenario, the use of usnic acid (UA), a natural compound, encapsulated into liposomes is proposed as a new approach in multidrug-resistant tuberculosis (MDR-TB) therapy. Thus the aim of this st
Mem. Inst. Oswaldo Cruz. Publicado em: 29/04/2016
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3. Interaction of antimicrobial peptide Plantaricin149a and four analogs with lipid bilayers and bacterial membranes
The amidated analog of Plantaricin149, an antimicrobial peptide from Lactobacillus plantarum NRIC 149, directly interacts with negatively charged liposomes and bacterial membranes, leading to their lysis. In this study, four Pln149-analogs were synthesized with different hydrophobic groups at their N-terminus with the goal of evaluating the effect of the mod
Braz. J. Microbiol.. Publicado em: 04/02/2014
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4. Peptídeos antimicrobianos: síntese, ensaios biológicos, estudos termodinâmicos e análise estrutural por RMN em meios biomiméticos
Many organisms employ noxious chemicals (e.g., amines, steroid derivatives, alkaloids and peptides) to defend themselves against predators and pathogenic microrganisms. Among these chemical agents stand out peptides that can be found in a wide variety of organisms including bacteria, fungi, plants, insects, fish, amphibians,arachnids and mammals. The vast ma
Publicado em: 2010
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5. Genic transfer in sperm cells in Mus musculus and Ramdia quelem / Transferência gênica em células espermáticas de Mus musculus e Ramdia quelen
Transgenic animals have been used as biological models in studies of the genes functions and their mechanisms of action, as well as to improve animal production. Researchers are trying to produce transgenic animals that will be organs donors in xenotransplants. Another use of the transgenic animal is in the production of recombinant proteins for pharmaceutic
Publicado em: 2009
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6. Studies of the kinetic characteristics of alkaline phosphatase reconstituted in vesicular systems / Estudos das características cinéticas da fosfatase alcalina reconstituída em sistemas vesiculares
Alkaline phosphatase is a multifunctional enzyme, capable of hydrolyzing phosphate monoesters, pyrophosphate, phosphodiesters, as well as catalyzing transphosphorylation reactions, and it is named "alkaline" due to its ability to perform these reactions more efficiently in pH above the neutral (pH 8-11). The aim of this work was to standardize a methodology
Publicado em: 2008
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7. Preparação, caracterização e marcação de lipossomas pH - sensíveis com tecnécio-99m para identificação de focos inflamatórios
Physicochemical characterization of conventional and long-circulating pH-sensitive liposomes (DOPE/CHEMS and aPEG2000-DSPE or mPEG2000-DSPE/DOPE/CHEMS, respectively) as well as conventional and long-circulating non-pH-sensitive liposomes (DOPC/COL and aPEG2000-DSPE or mPEG2000-DSPE/DOPC/COL, or mPEG2000- DSPE/HSPC/COL, respectively) showed mean diameter vesi
Publicado em: 2007
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8. Detection of anti-cardiolipin antibodies from real sera using polymerized liposomes / Detecção de anticorpos anti-cardiolipidina em soros reais utilizando lipossomas polimerizados
This work studies the detection of anticardiolipin IgG present in the sera o patients with autoimmune diseases , using polymerized liposomes. The advantage of this system is the molecular recognition and transduction of signal in a single step. The use of real sera, instead reference sera, aimed to evaluate the potentiality of polymerized liposomes to applic
Publicado em: 2007
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9. Atividade antimicobacteriana, citotoxicidade e interaÃÃo com macrÃfagos J774 de lipossomas contendo Ãcido Ãsnico
Secondary lichen metabolite usnic acid (UA) [2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bH)-dibenzofurano] is known by its antimicrobial activity against gram-positive bacteria and mycobacteria. Pulmonary tuberculosis is characterized by involvement of macrophages containing inside a large number of Mycobacterium tuberculosis. Liposomes have long been
Publicado em: 2006
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10. "Propriedades estruturais de agregados anfifílicos catiônicos: interação com material genético" / structural properties of cationic amphiphilic aggregates: interaction with genetic material
Though less efficient than viral vectors, cationic lipids have been used as carriers in gene therapy. They offer several advantages over viral vectors, including the low immunogenic and inflammatory responses, the potential transfer of unlimited-size expression units, and the possibility for engineered cell-specific targeting. However, the interaction betwee
Publicado em: 2006
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11. Benznidazole vs benznidazole in multilamellar liposomes: how different they interact with blood components?
In spite of its widespread use, benznidazole's (BNZ) toxicity and low efficacy remains as major drawbacks that impair successful treatments against Chagas disease. Previously, attempting to increase the selectivity and reduce its toxicity on infected tissues, multilamellar liposomes (MLV) composed of hydrogenated soybean phosphatidylcholine (HSPC): distearoy
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-04
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12. Desenvolvimento e avaliação farmacologica de formulações de liberação controlada com anestesicos locais amino-amidas ciclicos : bupivacaina, mepivacaina e ropivacaina / Development and pharmacological evaluation of drug-delivery systems for cyclic amino-amide local anesthetics: bupivacaine, mepivacaine and ropivacaine
Local anesthetics (LA) are among the different classes of pharmacological compounds used to attenuate or to eliminate pain. These drugs, which are able to reversibly block the excitation/transmission of the nerve impulse in axons have a relatively short action and a significant toxicity to the Central Nervous and Cardiovascular systems. In order to prolong t
Publicado em: 2005