Integrins Immunohistochemistry
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Correlation between Beta1 integrin expression and prognosis in clinically localized prostate cancer
Integrins are transmembrane glycoprotein receptors that regulate cell-matrix interactions, thus functioning as sensors from the environment. They also act as cell adhesion molecules that are responsible for the maintenance of the normal epithelial phenotype. Some studies have reported a correlation between carcinogenesis and changes in integrin expression, e
Int. braz j urol.. Publicado em: 2013-06
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2. Imunoexpressão de caderinas e integrinas no desenvolvimento do epitélio cutâneo humano / Immunoexpression of cadherins and integrins in the development of human skin epithelium
Introduction: Cadherins and integrins are important for maintenance of tissue integrity and in signal transduction during skin development. Distribution of these molecules in human skin development was investigated and associated with markers of differentiation, cytokeratins (CK) and involucrin (INV). Methods: Using immunohistochemistry expression of E- and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2011
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3. Integrinas ligantes do peptídio RGD atuam como mecanotransdutores na cartilagem do côndilo mandibular de ratos submetidos a tratamento ortopédico funcional. / RGD-binding integrins participate in mechanotransduction in the mandibular condylar cartilage of rats submitted to functional orthopaedic treatment.
The mandibular propulsor appliance is widely used in dentistry to modulate the growth of the condylar cartilage, through forces generated by postural changes in the orofacial musculature. The aim of this study was to evaluate the role of fibronectin (FN)-binding integrins in the transduction of mechanical forces generated by the appliance in rats. By immunoh
Publicado em: 2007
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4. Expressão imuno-histoquímica das integrinas α2ß1, α3ß1, e α5ß1, em mucosa oral normal, hiperplasia fibroepitelial inflamatória oral e displasia epitelial oral
The objective of this study was perform by the streptoavidin-biotin technique an immunohistochemical analysis of α2β1, α3β1e α5β1 integrins in 11 normal oral mucosa (NOM), 16 oral inflammatory fibroepithelial hyperplasia (OIFH) and 25 oral epithelial dysplasia (OED) (16 mild, 2 moderates and 7 severe), to determine if exists qua
Publicado em: 2006
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5. Expressão imuno-histoquímica das integrinas α2ß1, α3ß, e α5ß1, em carcinoma epidermóide de lábio inferior e língua
A imprevisibilidade do comportamento biológico do carcinoma epidermóide oral vem justificando um grande número de pesquisas utilizando biomarcadores que possam contribuir para um melhor entendimento do curso evolutivo dessa neoplasia. Por estarem envolvidas em relações entre as células tumorais e constituintes da matriz extracelular, as integrinas vêm
Publicado em: 2006
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6. Expressão imuno-histoquimica de colagenase-1 e gelatinases A e B em mixomas odontogênicos e papilas de germes dentários
The odontogenic myxoma shares cellular and structural aspects with dental papilla, which has been implicated as probable origin of this neoplasm. The aim of the present study was to perform a comparative immunohistochemical analysis for the expression of collagenase-1 (MMP-1) and gelatinases A (MMP-2) and B (MMP-9) in odontogenic myxomas and dental papilla o
Publicado em: 2006
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7. Expressão imuno-histoquímica das integrinas a2ß1, a3ß1 e a5ß1 em adenoma pleomórfico de glândula salivar menor e maior e carcinoma adenóide cístico / Immunohistochemical expression of D2E1, D3E1 e D5E1 integrins in pleomorphic adenoma from minor and major salivary glands and adenoid cystic carcinoma
Pleomorphic adenoma and adenoid cystic carcinoma (ACC) consist benign and malignant neoplasm from salivary gland, respectively. These neoplasms share some characteristics, such as cellular origin and considerable production of extracellular matrix, however, with distinct biological behavior. The aim of the present study was to compare the expression of D2E1,
Publicado em: 2005
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8. Aberrant cell adhesion molecule expression in human bronchopulmonary sequestration and congenital cystic adenomatoid malformation
In many organs, integrins and cadherins are partly regulated by Hox genes, but their interactions in airway morphogenesis and congenital lung diseases are unknown. We previously showed that the Hox protein HoxB5 is abnormally increased in bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM), congenital lung lesions with
American Physiological Society.
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9. p27kip1 acts as a downstream effector of and is coexpressed with the β1C integrin in prostatic adenocarcinoma
Integrins are a large family of transmembrane receptors that, in addition to mediating cell adhesion, modulate cell proliferation. The β1C integrin is an alternatively spliced variant of the β1 subfamily that contains a unique 48–amino acid sequence in its cytoplasmic domain. We have shown previously that in vitro β1C inhibits cell proliferation and tha
American Society for Clinical Investigation.
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10. Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces.
Osteopontin, a glycoprotein with a glycine-arginine-glycine-aspartate-serine (GRGDS) cell-binding domain, has been described in bone and is also known to be expressed in other organs, particularly kidney. The goal of the present work was to define the distribution of osteopontin synthesis and deposition in a wide variety of normal adult human tissues using a
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11. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice.
To better define the specific function of Mac-1 (CD11b) versus LFA-1 (CD11a) and the other CD11 integrins in vivo, we have disrupted murine CD11b by targeted homologous recombination in embryonic stem cells and generated mice which are homozygous for a mutation in CD11b. A null mutation was confirmed by Southern blotting, RNase protection assay, immunohistoc
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12. Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis
Hemangiomas are benign tumors of the vascular endothelium and are the most common tumors of infancy. These tumors are characterized by an initial phase of rapid proliferation, which is followed, in most cases, by spontaneous involution. Although most lesions resolve without complication, there are some cases in which hemangiomas can be life threatening when
The National Academy of Sciences.