Inosine
Mostrando 1-12 de 366 artigos, teses e dissertações.
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1. Characterisation of iunH gene knockout strain from Mycobacterium tuberculosis
BACKGROUND Tuberculosis (TB) is an infectious disease caused mainly by the bacillus Mycobacterium tuberculosis. The better understanding of important metabolic pathways from M. tuberculosis can contribute to the development of novel therapeutic and prophylactic strategies to combat TB. Nucleoside hydrolase (MtIAGU-NH), encoded by iunH gene (Rv3393), is an
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-03
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2. Rapid Detection of ACTG- and AK-Toxins in Alternaria alternata by LC-ESI-MS/MS Analysis and Antifungal Properties of Citrus Compounds
A methanol-soluble fraction of the dichloromethane extract from the culture broth of A. alternata AT4303 strain afforded the following five known mycotoxins: alternariol, alternariol monomethyl ether, altenusin, altenuene and altertoxin I. A hexane-soluble fraction of the dichloromethane extract yielded the steroids ergosterol and ergosterol peroxide, and al
J. Braz. Chem. Soc.. Publicado em: 2016-08
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3. Modulatory effect of iron chelators on adenosine deaminase activity and gene expression in Trichomonas vaginalis
Trichomonas vaginalis is a flagellate protozoan that parasitises the urogenital human tract and causes trichomoniasis. During the infection, the acquisition of nutrients, such as iron and purine and pyrimidine nucleosides, is essential for the survival of the parasite. The enzymes for purinergic signalling, including adenosine deaminase (ADA), which degrades
Mem. Inst. Oswaldo Cruz. Publicado em: 23/10/2015
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4. Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C
Inosine triphosphatase (ITPA) single nucleotide polymorphisms (SNPs) are strongly associated with protection against ribavirin (RBV)-induced anaemia in European, American and Asian patients; however, there is a paucity of data for Brazilian patients. The aim of this study was to evaluate the ITPA SNP (rs7270101/rs1127354) frequency in healthy and hepatitis C
Mem. Inst. Oswaldo Cruz. Publicado em: 07/07/2015
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5. Synthesis and Evaluation of Thiazolyl-1H-benzo[
d ]imidazole Inhibitors ofMycobacterium tuberculosis Inosine Monophosphate DehydrogenaseUsing an orthologue-based design approach, we synthesized and assayed a series of thiazolyl-1
H -benzo[d ]imidazole derivatives as inhibitors ofMycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mt IMPDH). From these experiments, a benzo[d ] imidazole compoundJ. Braz. Chem. Soc.. Publicado em: 2015-07
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6. Modelo de regulação dos nucleotídeos extracelulares no líquido superficial das vias respiratórias
Extracellular nucleotides play a key role in the regulation of mucociliary clearance and thus are essential in protecting the airways against inhaled pathogens. Adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) nucleotides are secreted by the respiratory epithelium to the airway surface liquid, where they are metabol
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/03/2012
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7. Effects of crossbreeding on slaughter traits and breast muscle chemical composition in chinese chickens
We investigated the effects of crossbreeding on slaughter traits and the chemical composition of chicken breast muscle. Trials were conducted using 120 broilers from four lines: Xiao-Shan chicken (XS), Xian-Ju chicken (XJ), Xiao-Shan chicken♂♂ × Xian-Ju chicken♀♀ (Zhenan 1, ZNY1) and Xiao-Shan chicken♂♂ × (Guang-Xi Yellow chicken♂♂×Xian-Ju
Revista Brasileira de Ciência Avícola. Publicado em: 2011-12
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8. Effects of DMA (Quinazoline Compound) on inflammatory process / O efeito do DMA (composto quinazolinico) sobre o processo inflamatorio
: Inflammation has a main role in several connective tissue diseases and is an important element of infectious disease physiopathology. Recently it has been linked to obesity, diabetes and cardiovascular diseases. Adenosine, among the various inflammatory process mediators, is a potent autocoid and its bioavailability is limited by catabolism to inosine by a
Publicado em: 2008
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9. The 3' terminal sequence of the inosine monophosphate dehydrogenase gene encodes an active domain in the yeast Schizosaccharomyces pombe
The gua1 gene encoding inosine monophosphate dehydrogenase (IMPDH), which catalyses the first step in de novo biosynthesis of guanosine monophosphate (GMP), was cloned in the yeast Schizosaccharomyces pombe by functional complementation of a gua1ura4-D18 mutant strain from a S. pombe DNA genomic library. Complementation analysis revealed a 1.2 kb fragment wh
Genetics and Molecular Biology. Publicado em: 2006
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10. A chemical assessment of freshness in stored adductor muscle from scallops
The postmortem catabolism of adenosine triphosphate (ATP) in cold-stored adductor muscles from scallops (Zygochlamys patagónica) was studied. Changes in the pH of stored muscles were also studied. The ATP content increased for a short time after death and afterwards decreased up to 24 hr of storage. Thereafter, the nucleotide level remained unchanged up to
Brazilian Journal of Chemical Engineering. Publicado em: 2003-06
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11. Efeitos biológicos da peçonha da aranha Parawixia bistriata em ratos: isolamento e caracterização química parcial de uma neurotoxina pró-convulsivante / Biological effects of the Parawixia bistriata spider venon in rats: isolation and partially chemical characterization of a convulsant neurotoxin.
Arthropod venoms are rich sources of neurotoxins, molecular tools with selective and specific actions over the mamalian central nervous system with great clinical and scientific importance. Previous work of our laboratory showed that the spider venom of Parawixia bistriata, when injected by intracerebroventricular (i.c.v.) route, induced convulsive seizures
Publicado em: 2003
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12. Use of nucleotides in weanling rats with diarrhea induced by a lactose overload: effect on the evolution of diarrhea and weight and on the histopathology of intestine, liver and spleen
Until recently, dietary sources of nucleotides were thought not to be essential for good nutrition. Certain states with higher metabolic demands may require larger amounts that cannot be provided by endogenous production. The objective of the present study was to determine the action of nucleotides on the recovery from lactose-induced diarrhea in weaned rats
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-02