Inhibitor Specificity
Mostrando 1-12 de 495 artigos, teses e dissertações.
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1. In silico prediction of inhibitory potential of a punicalagin β-anomer against SARS-COV-2 main protease (MPRO)
The pandemic caused by the new coronavirus has resulted in a global health emergency and has prompted an urgent need for new treatment strategies. No target-specific drugs are currently available for SARS-CoV-2, but new drug candidates targeting the viral replication cycle are being explored. A prime target of drug-discovery efforts is the SARS-CoV-2 main pr
Química Nova. Publicado em: 2022
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2. Can natural killer cell activity help screen patients requiring a biopsy for the diagnosis of prostate cancer?
ABSTRACT Purpose To evaluate the usefulness of natural killer cell activity (NKA) in diagnosing prostate cancer (PC). Materials and Methods The medical records of patients who underwent transrectal prostate biopsy (TRBx) at Korea University Ansan Hospital between May 2017 and December 2017 were retrospectively reviewed. NKA levels were measured using NK
Int. braz j urol.. Publicado em: 2020-03
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3. Editorial Comment: Does YouTube include high-quality resources for training on laparoscopic and robotic radical prostatectomy?
ABSTRACT Purpose To evaluate the usefulness of natural killer cell activity (NKA) in diagnosing prostate cancer (PC). Materials and Methods The medical records of patients who underwent transrectal prostate biopsy (TRBx) at Korea University Ansan Hospital between May 2017 and December 2017 were retrospectively reviewed. NKA levels were measured using NK
Int. braz j urol.. Publicado em: 2020-03
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4. On-Flow Ligand Screening Assay Based on Immobilized Nucleoside Diphosphate Kinase B from Homo sapiens
We describe an on-flow zonal affinity-based chromatography assay to screen ligands for the nucleoside diphosphate kinase B enzyme (NME2) from Homo sapiens. For the first time, we have covalently immobilized NME2 on the surface of an open fused silica capillary reactor (NME2-ICER) and placed the reactor before the analytical column, which resulted in a two-di
J. Braz. Chem. Soc.. Publicado em: 24/10/2019
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5. Performance of diagnostic biomarkers in predicting liver fibrosis among hepatitis C virus-infected Egyptian children
The aim of the present study was to identify specific markers that mirror liver fibrosis progression as an alternative to biopsy when biopsy is contraindicated, especially in children. After liver biopsies were performed, serum samples from 30 hepatitis C virus (HCV) paediatric patients (8-14 years) were analysed and compared with samples from 30 healthy sub
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-11
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6. Mutants of common bean alpha-amylase inhibitor-2 as an approach to investigate binding specificity to alpha-amylases.
Despite the presence of a family of defense proteins, Phaseolus vulgaris can be attacked by bruchid insects resulting in serious damage to stored grains. The two distinct active forms of a-amylase inhibitors, a-AI1 and a-AI2, in P. vulgaris show different specificity toward a-amylases. Zabrotes subfasciatus a-amylase is inhibited by a-AI2 but not by a-AI1. I
Pesquisa Agropecuária Brasileira. Publicado em: 2011
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7. Mutants of common bean alpha-amylase inhibitor-2 as an approach to investigate binding specificity to alpha-amylases.
Despite the presence of a family of defense proteins, Phaseolus vulgaris can be attacked by bruchid insects resulting in serious damage to stored grains. The two distinct active forms of a-amylase inhibitors, a-AI1 and a-AI2, in P. vulgaris show different specificity toward a-amylases. Zabrotes subfasciatus a-amylase is inhibited by a-AI2 but not by a-AI1. I
Pesquisa Agropecuária Brasileira. Publicado em: 2011
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8. Analysis of binding properties and specificity through identification of the interface forming residues (IFR) for serine proteases in silico docked to different inhibitors.
Background: Enzymes belonging to the same super family of proteins in general operate on variety of substrates and are inhibited by wide selection of inhibitors. In this work our main objective was to expand the scope of studies that consider only the catalytic and binding pocket amino acids while analyzing enzyme specificity and instead, include a wider cat
BMC Structural Biology. Publicado em: 2011
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9. Cloning, expression and characterisation of an HtrA-like serine protease produced in vivo by Mycobacterium leprae
Members of the high temperature requirement A (HtrA) family of chaperone proteases have been shown to play a role in bacterial pathogenesis. In a recent report, we demonstrated that the gene ML0176, which codes for a predicted HtrA-like protease, a gene conserved in other species of mycobacteria, is transcribed by Mycobacterium leprae in human leprosy lesion
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-12
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10. CARACTERIZAÇÃO ESTRUTURAL E IMUNOQUÍMICA DE GLICOINOSITOL FOSFORILCERAMIDAS DE Aspergillus fumigatus. EFEITO DE INIBIDORES DE SÍNTESE DE GLICOESFINGOLIPÍDEOS EM FUNGOS PATOGÊNICOS. / Structural and immunochemical characterization of glycosylinositol phosphorylceramides from Aspergillus fumigatus. Effect of glycosphingolipid synthesis inhibitors on pathogenic fungi.
The search for alternatives for new antifungal therapies led our laboratory to analyze the molecular structures of specific glycosphingolipids (GSLs) present in fungi but not in mammals. We analyze the molecular structures of glycosylinositol phosphorylceramides (GIPCs) from the opportunistic fungus Aspergillus fumigatus. GSLs were extracted and purified by
Publicado em: 2006
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11. Isolamento e caracterização de um novo conjunto de serinoproteases com atividade trombina-like e de L-aminoacido oxidase do veneno de Crotalus durissus cascavella / Isolation and characterization of a new serine proteases group with thrombinin-like and L-amino acid oxidase activity from Crotalus durissus cascavella
The use of the isolated toxins from poisons as molecular tools in the understanding of diverse physiological and pathological events has been proved by some works in literature. The serpent Crotalus durissus cascavella is found in the areas of Caatinga Northeast of Brazil, since Maranhão until North of the state of Minas Gerais, and in spite of it hasn?t be
Publicado em: 2006
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12. Acid phosphatase from the microalgae Selenastrum capricornutum : extraction, characterization and effect of agriculture pollutants / Fosfatase acida da microalga Selenastrum capricornutum : extração, caracterização e efeito de poluentes de origem agricola
Selenastrum capricornutum is an unicellular green algae widely distributed in freshwater and soils among the world. Because this cosmopolitan characteristic its use is recommended by national and international protocols in ecotoxicity studies. Algae acid phosphatase plays important roles in the metabolism such as decomposing organic phosphates into free phos
Publicado em: 2005