Inhibition
Mostrando 13-24 de 28559 artigos, teses e dissertações.
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13. DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE)
Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12α-olide (1), and of nine known ent-abietane diterpenes jolkinolide A (2), jolkinolide E (3), euphorin H (4),
Química Nova. Publicado em: 2022
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14. RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients
Abstract Introduction: Coronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries. Our objective in this study is to investigate the RhoA/Rho-associated kinase (ROCK)-1 signaling pathw
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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15. Biologically Active Volatile Organic Compounds (VOCs) Produced by Rhizospheric Actinobacteria Strains Inhibit the Growth of the Phytopathogen Colletotrichum musae
The antifungal potential of volatile organic compounds (VOCs) produced by actinobacterial strains Streptomyces sp. (ACTB-77) and Amycolatopsis sp. (ACTB-290) from the rhizosphere of Caatinga plants against Colletotrichum musae was investigated. VOCs produced by these microorganisms (axenic and co-culture) were investigated using headspace-solid phase micro-e
Journal of the Brazilian Chemical Society. Publicado em: 2022
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16. EFFECT OF REACTION CONDITIONS ON PARTICLE SIZE OF ZNO NANOPARTICLES VIA CONTROLLED PRECIPITATION METHOD AND IN-VITRO ANTIBACTERIAL CAPACITY
High-yield ZnO spheroidal nanoparticles with an average diameter around 23 nm (≈ 25% frequency) and 30 nm (≈ 28% frequency) were obtained by controlled semicontinuous precipitation at low temperatures. This synthesis was obtained from hydrozincite (Zn5(CO3)2(OH)6) as primary nanoparticles. The Zn5(CO3)2(OH)6 nanoparticles were synthesized by hydrolysis o
Química Nova. Publicado em: 2022
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17. BIODEGRADABLE SODIUM CARBOXYMETHYL CELLULOSE MEMBRANES CONTAINING MELALEUCA ESSENTIAL OILS FOR WOUND CARE MATERIAL
NaCMC is a biocompatible polymer that can be crosslinked with citric acid to form a gel matrix. Melaleuca oils have antimicrobial and anti-inflammatory properties with potential for wound healing. The goal of this work was to investigate the characteristics of NaCMC-Melaleuca oils gels. The gels were characterized by FTIR, TGA, mechanical analysis, and in vi
Química Nova. Publicado em: 2022
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18. Low-dose paclitaxel modulates the cross talk between the JNK and Smad signaling in primary biliary fibroblasts
SUMMARY OBJECTIVE: The objective of this study was to explore the molecular mechanism underlying the occurrence of benign bile duct stricture and the target of low-dose paclitaxel in the prevention of benign bile duct stricture. METHODS: Under the stimulation of transforming growth factor beta 1, the expression of collagen type I and connective tissue grow
Revista da Associação Médica Brasileira. Publicado em: 2022
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19. Synthesis of Eugenol-Fluorinated Triazole Derivatives and Evaluation of Their Fungicidal Activity
Eugenol (C10H12O2, 4-allyl-2-methoxyphenol) is a phenolic natural product that has several biological activities and possibilities of applications. It is herein described the synthesis of eugenol-fluorinated triazole derivatives and evaluation of their fungicidal activity. The reaction of eugenol with epichlorohydrin resulted in the preparation of (±)-2-((4
Journal of the Brazilian Chemical Society. Publicado em: 2022
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20. METABOLIC PROFILING AND CYTOTOXIC ACTIVITY OF METHANOL EXTRACTS FROM CHAMAECRISTA DUCKEANA (P. BEZERRA & A. FERN.) H. S. IRWIN & BARNEBY (LEGUMINOSAE, CAESALPINIOIDEAE)
The genus Chamaecrista comprises more than 330 species, with only a few studies on their chemical composition and biologic activities. In this study, the phytochemical profile of leaf, stems, and fruits extracts of the C. duckeana were examined by UPLC ESI HRMS analysis to determine possibly bioactive constituents. The antioxidant activity was carried out th
Química Nova. Publicado em: 2022
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21. Phytocomponents, Evaluation of Anticholinesterase Activity and Toxicity of Hydroethanolic Extracts of Parkia platycephala Benth.
This study evaluated the chemical composition, antioxidant and anticholinesterase activities, and the toxicity of hydroethanolic extracts of the Parkia platycephala Benth. Hot extraction with 70% hydroethanolic solution was used to obtain crude extracts of the leaf (LE), bark (BE), flower (FE), and seed (SE). Separation and identification of the compounds we
Journal of the Brazilian Chemical Society. Publicado em: 2022
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22. Antibacterial Profile in vitro and in vivo of New 1,4-Naphthoquinones Tethered to 1,2,3-1H-Triazoles Against the Planktonic Growth of Streptococcus mutans
The cariogenic processes are mainly caused by the bacterium Streptococcus mutans (S. mutans) and consist of the demineralization of the tooth that occurs when the acid production overcomes the natural repair or if a problem occurs in the last one. In this work, we performed the synthesis of twenty-one 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles (8a-8k
Journal of the Brazilian Chemical Society. Publicado em: 2022
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23. Antioxidant Properties of Croton zehntneri Pax et Hoffm. Essential Oil and Its Inclusion Complex with β-Cyclodextrin Prepared by Spray Drying
Croton zehntneri Pax et Hoffm. is a plant from Northeastern Brazil, whose main component of its essential oil is estragole. Its thermal instability and low aqueous solubility prevent its technological application. This study aimed to prepare and characterize the Croton zehntneri essential oil (CZEO) complexed with β-cyclodextrin (β-CD), and to evaluate ant
Journal of the Brazilian Chemical Society. Publicado em: 2022
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24. Evaluation of the efficacy, safety, and side effects of secukinumab in patients with moderate-to-severe psoriasis: real-world data from a retrospective multicenter study
Abstract Background: Clinical studies have demonstrated that IL-17A inhibition with secukinumab is effective for clearing the skin of patients with psoriasis and has a favorable safety profile. Objective: The authors aim to determine whether secukinumab is effective and safe for the treatment of moderate-to-severe chronic psoriasis based on clinical experi
Anais Brasileiros de Dermatologia. Publicado em: 2022