Inhibins
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Avaliação da função das células de Sertoli testiculares em pacientes do sexo masculino com lúpus eritematoso sistêmico / Testicular Sertoli cell function evaluation in male systemic lupus erytemathosus patients
Objetivo: Avaliar a função das células testiculares de Sertoli em homens com lúpus eritematoso sistêmico (LES). Métodos: Trinta e quatro pacientes consecutivos foram prospectivamente selecionados para avaliar a função das células testiculares de Sertoli pelos níveis séricos da inibina B. Características clínicas, tratamento, análises dos esperm
Publicado em: 2008
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2. Geração de inibina A após estímulo gonadotrófico: novo método de detecção de tecido ovariano em pacientes com anomalia da diferenciação sexual / Inhibin A generation after gonadotropin stimulus: a new method to detect ovarian tissue in true hermaphrodites
Introduction: True hermaphrodism (TH) is characterized by the presence of ovarian and testicular tissue in the same patient comprises 5% of the intersex cases. A large spectrum of phenotypical variation is observed, ranging from normal female genitalia to normal male genitalia, covering a wide range of intermediary presentations, it becomes very difficult to
Publicado em: 2006
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3. Normal Reproductive Function in InhBP/p120-Deficient Mice
The inhibins are gonadal transforming growth factor β superfamily protein hormones that suppress pituitary follicle-stimulating hormone (FSH) synthesis. Recently, betaglycan and inhibin binding protein (InhBP/p120, also known as the product of immunoglobulin superfamily gene 1 [IGSF1]) were identified as candidate inhibin coreceptors, shedding light on the
American Society for Microbiology.
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4. Human seminal alpha-inhibins: detection in human pituitary, hypothalamus, and serum by immunoreactivity.
An antiserum generated in rabbits against human seminal alpha-inhibin-52 has been used to develop a sensitive radioimmunoassay for the detection of alpha-inhibins. The alpha-inhibin-52 antiserum reacts with alpha-inhibin-92 and alpha-inhibin-31 with equal avidity. These peptides were found to be present in human pituitary, hypothalamus, and serum. In exclusi
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5. Human seminal alpha inhibins: isolation, characterization, and structure.
Two additional peptides with inhibin-like activity have been isolated from human seminal plasma. One consists of 52 amino acids and the other, 92 amino acids. They are designated alpha-inhibin-52 and alpha-inhibin-92. Sequence analyses show that the NH2-terminal 31 amino acids of alpha-inhibin-52 are identical to the structure of the inhibin-like peptide pre
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6. Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes.
We investigated the binding of 125I-labeled alpha-inhibin-92 (a 92-residue peptide) to human pituitary membrane preparations. Unlabeled alpha-inhibin-92 competed effectively with the labeled peptide for binding to the membranes. Binding was also inhibited by both alpha-inhibin-52 and alpha-inhibin-31, but less effectively. Scatchard analysis of the alpha-inh
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7. Endogenous Betaglycan Is Essential for High-Potency Inhibin Antagonism in Gonadotropes
Inhibins are endocrine hormones that regulate gametogenesis and reproduction through a negative feedback loop with FSH. Inhibin action involves antagonism of signaling by activin or other TGFβ family ligands. In transfection assays, antagonism by inhibin can be potentiated by betaglycan, a coreceptor for selected TGFβ family ligands. We tested whether beta
The Endocrine Society.
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8. Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone.
A Mr 35,000 protein with follicle-stimulating hormone release-inhibitory activity was isolated from porcine ovarian follicular fluid by heparin-Sepharose affinity chromatography, gel filtration on Sephacryl S-200, and multiple steps of high-performance liquid chromatography. The isolated molecule is highly enriched in cysteines and is composed of a single po
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9. Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice.
Activins and inhibins, members of the type beta transforming growth factor superfamily of growth regulatory proteins, are produced in multiple tissues and affect diverse physiologic processes. Using embryonic stem cell technology, we previously demonstrated that inhibin can function as a gonadal tumor suppressor. In this study, we show that development of go
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10. Activin and inhibin in the human adrenal gland. Regulation and differential effects in fetal and adult cells.
Recent experimental data have revealed that activins and inhibins exert pivotal effects on development. As part of our studies on growth and differentiation of the human fetal adrenal gland, we examined the subunit localization, as well as the mitogenic and steroidogenic actions of activin and inhibin in human fetal and adult adrenals. All three activin and
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11. Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation.
Activins and inhibins belong to the transforming growth factor beta (TGF-beta)-like superfamily and exert their effects on a broad range of cellular targets by modulating cell differentiation and proliferation. Members of this family interact with two structurally related classes of receptors (type I and type II), both containing a serine/threonine kinase do