Inflammasome
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. AIM2 inflammasome activation may mediate high mobility group box 1 release in murine allergic rhinitis
Resumo Introdução: A proteína do grupo Box-1 de alta mobilidade participa da patogênese da rinite alérgica. A ativação do inflamassoma pode mediar a liberação de proteína do grupo Box-1 de alta mobilidade. O papel do inflamassoma ausente no melanoma 2 na rinite alérgica permanece incerto. Objetivo: Investigar a função do inflamassoma ausente n
Brazilian Journal of Otorhinolaryngology. Publicado em: 2022
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2. Effects of 1,25-dihydroxyvitamin D3 on experimental periodontitis and AhR/NF-κB/NLRP3 inflammasome pathway in a mouse model
Abstract Vitamin D has been known to have important regulatory functions in inflammation and immune response and shows inhibitory effects on experimental periodontitis in animal models. However, the potential mechanism has yet to be clarified. Recent studies have highlighted Aryl hydrocarbon receptor (AhR) and its downstream signaling as a crucial regulator
J. Appl. Oral Sci.. Publicado em: 04/11/2019
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3. Increased levels of plasma IL-1b and BDNF can predict resistant depression patients
RESUMO FUNDAMENTAÇÃO: Não há fortes evidências sobre a associação entre o perfil inflamatório e o padrão de resposta ao tratamento medicamentoso em pacientes depressivos que podem resultar em ocorrência de doença coronariana. OBJETIVO: O objetivo deste estudo foi comparar os marcadores de aterosclerose subclínica, o perfil inflamatório e a pro
Rev. Assoc. Med. Bras.. Publicado em: 11/04/2019
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4. NLRP3 inflammasome signaling as an early molecular response is negatively controlled by miR-186 in CFA-induced prosopalgia mice
The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most frequently studied in the central nervous system and has been linked to neuropathic pain. In this study, a post-translational mechanism of microRNA (miR)-186 via regulating the expression of NLRP3 in the complete Freund's adjuvant (CFA)-treated mice was investigated. The
Braz J Med Biol Res. Publicado em: 16/07/2018
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5. Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis
Abstract: Skin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning as an anatomical barrier, secrete cytokines, such as TN
An. Bras. Dermatol.. Publicado em: 2018-03
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6. Vitamin D3 levels and NLRP3 expression in murine models of obese asthma: association with asthma outcomes
Vitamin D (25(OH)D3) is an essential nutrient that plays a role in the immune system. Serum 25(OH)D3 is found to be associated with asthma. However, the role of vitamin D in obese asthma remains unclear. Therefore, we investigated the association between vitamin D levels and asthma outcomes in a murine model of obese asthma. We also evaluated NLRP3 inflammas
Braz J Med Biol Res. Publicado em: 13/11/2017
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7. Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis
Osteosarcoma (OS) is the most common primary bone malignancy, but current therapies are far from effective for all patients. A better understanding of the pathological mechanism of OS may help to achieve new treatments for this tumor. Hence, the objective of this study was to investigate ego modules and pathways in OS utilizing EgoNet algorithm and pathway-r
Braz J Med Biol Res. Publicado em: 16/02/2017
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8. Inflammasomes and dermatology
Abstract: Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage when in
An. Bras. Dermatol.. Publicado em: 2016-10
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9. NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) me
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-11
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10. Caspase-1 activation and pore formation in murine macrophages infected with Legionella pneumophila / Ativação de caspase-1 e formação de poros em macrófagos infectados por Legionella pneumophila
Legionella pneumophila, the etiological agent of Legionnaires disease, is known to trigger pore formation in bone marrow-derived macrophages (BMMs) by mechanisms dependent on the type IVB secretion system known as Dot/Icm. Here, we used several mutants of L. pneumophila in combination with knockout mice to assess the host and bacterial factors involved in po
Publicado em: 2010
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11. The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes*
The inflammasome is a multiprotein complex involved in innate immunity. Activation of the inflammasome causes the processing and release of the cytokines interleukins 1β and 18. In primary macrophages, potassium ion flux and the membrane channel pannexin 1 have been suggested to play roles in inflammasome activation. However, the molecular mechanism(s) gove
American Society for Biochemistry and Molecular Biology.
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12. Inflammasome-mediated regulation of hepatic stellate cells
The inflammasome is a cytoplasmic multiprotein complex that has recently been identified in immune cells as an important sensor of signals released by cellular injury and death. Analogous to immune cells, hepatic stellate cells (HSC) also respond to cellular injury and death. Our aim was to establish whether inflammasome components were present in HSC and co
American Physiological Society.