Indirubin
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Indican, Ãndigo e indirubina de folhas de indigofera suffruticosa sobre linhagens celulares neoplÃsicas
Ãndigo e Indirubina sÃo derivados da oxidaÃÃo e dimerizaÃÃo do indoxil e isatan e liberados pelo composto precursor, Indican ou Isatan B. A Indirubina inibe a sÃntese de DNA de algumas linhagens celulares. Este trabalho experimental foi desenvolvido para avaliar os efeitos dos compostos quÃmicos identificados e isolados de folhas de Indigofera suffru
Publicado em: 2008
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2. Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic MiceS⃞
The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that displays interspecies differences with the human and mouse AHR C-terminal region sequences sharing only 58% amino acid sequence identity. Compared with the mouse AHR (mAHR), the human AHR (hAHR) displays ∼10-fold lower relative affinity for prototypical AHR ligands such
American Society for Pharmacology and Experimental Therapeutics.
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3. Case report: Purple urine bag syndrome
Purple urine bag syndrome (PUBS) was first reported in 1978. PUBS is rare, occurs predominantly in constipated women, chronically catheterized and associated with some bacterial urinary infections that produce sulphatase/phosphatase. The etiology is due to indigo (blue) and indirubin (red) or to their mixture that becomes purple. A chain reaction begins in t
BioMed Central.
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4. Enzymatic degradation of urinary indoxyl sulfate by Providencia stuartii and Klebsiella pneumoniae causes the purple urine bag syndrome.
The etiology of the purple urine bag syndrome (PUBS), in which the urinary catheter bag of some elderly patients develops intense purple coloration, was studied. The purple was found to be a mixture of indirubin dissolved in the plastic and indigo on its surface. Six patients with PUBS were studied, and Providencia stuartii was isolated from the urine of fiv
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5. Formation of indigo and related compounds from indolecarboxylic acids by aromatic acid-degrading bacteria: chromogenic reactions for cloning genes encoding dioxygenases that act on aromatic acids.
The p-cumate-degrading strain Pseudomonas putida F1 and the m- and p-toluate-degrading strain P. putida mt-2 transform indole-2-carboxylate and indole-3-carboxylate to colored products identified here as indigo, indirubin, and isatin. A mechanism by which these products could be formed spontaneously following dioxygenase-catalyzed dihydroxylation of the indo
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6. Lithium Blocks the c-Jun Stress Response and Protects Neurons via Its Action on Glycogen Synthase Kinase 3
Lithium has been used as an effective mood-stabilizing drug for the treatment of manic episodes and depression for 50 years. More recently, lithium has been found to protect neurons from death induced by a wide array of neurotoxic insults. However, the molecular basis for the prophylactic effects of lithium have remained obscure. A target of lithium, glycoge
American Society for Microbiology.
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7. Regulation of primary cilia formation by ceramide[S]
The primary cilium is an important sensory organelle, the regulation of which is not fully understood. We found that in polarized Madin-Darby Canine Kidney cells, the sphingolipid ceramide is specifically distributed to a cis-Golgi compartment at the base of the primary cilium. This compartment immunostained for the centrosome marker γ-tubulin, the Rho type
The American Society for Biochemistry and Molecular Biology.
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8. Inhibitors of Leishmania mexicana CRK3 Cyclin-Dependent Kinase: Chemical Library Screen and Antileishmanial Activity
The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of CRK3 impairs the parasite's viability within macrophages, thus further validating CRK3 as a potential drug target. A microtiter plate-based histone H1 kinase ass
American Society for Microbiology.