Incretin
Mostrando 1-12 de 28 artigos, teses e dissertações.
-
1. Effect of free fatty acids on insulin secretion, insulin sensitivity and incretin effect – a narrative review
ABSTRACT Deleterious effects of free fatty acids, FFAs, on insulin sensitivity are observed in vivo studies in humans. Mechanisms include impaired insulin signaling, oxidative stress, inflammation, and mitochondrial dysfunction, but the effects on insulin secretion are less well known. Our aim was to review the relationship of increased FFAs with insulin res
Arch. Endocrinol. Metab.. Publicado em: 2021-02
-
2. Obesity care: more urgent than ever
ABSTRACT Deleterious effects of free fatty acids, FFAs, on insulin sensitivity are observed in vivo studies in humans. Mechanisms include impaired insulin signaling, oxidative stress, inflammation, and mitochondrial dysfunction, but the effects on insulin secretion are less well known. Our aim was to review the relationship of increased FFAs with insulin res
Arch. Endocrinol. Metab.. Publicado em: 2021-02
-
3. Ação do inibidor da enzima dipeptidil peptidase 4 sobre o pré-condicionamento isquêmico em pacientes portadores de diabetes mellitus tipo 2 e doença arterial coronariana estável / Effect of dipeptidyl peptidase-4 enzyme inhibitor on ischemic preconditioning in patients with type 2 diabetes and symptomatic coronary artery disease
Ischemic preconditioning (IPC) refers to the phenomenon in which short periods of myocardial ischemia and reperfusion promote resistance to a subsequent prolonged ischemic insult. Some hypoglycemic drugs, such as glibenclamide and repaglinide, are able to inhibit this protective phenomenon probably by its effects as blockers of adenosine triphosphate-depende
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/10/2012
-
4. O efeito pró-apoptótico de oligômeros da amilina humana não é potencializado pela lipotoxicidade em ilhotas pancreáticas de rato em cultura / The pro-apoptotic effect of human amylin oligomers is not potentiated by lipotoxicity in rat pancreatic islets in culture
The amyloid deposit is a common histopathological feature in patients with type 2 diabetes mellitus (T2DM) and it seems to be related to the pancreatic beta cell dysfunction characteristic of this disease. A study previously developed in our laboratory found that human amylin oligomers decrease mRNA expression of the glucose-dependent insulinotropic polypept
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/07/2012
-
5. Avaliação das incretinas GLP-1 e PYY em pacientes com Diabetes Mellitus 2 submetidos a Duodenal Swicth Parcial / Evaluation of the incretin GLP-1 and PYY in patiens with Diabetes Mellitus 2 undergoing Partial Duodenal Swicth
Diabetes mellitus do tipo 2 (DM2), assim como a Síndrome Metabólica (SM), é uma desordem metabólica e multifatorial que atualmente se apresenta como pandemia mundial com reflexos na morbimortalidade, possivelmente em decorrência do descompasso entre a evolução biológica e cultural do homem. Foi objeto de investigação do presente estudo analisar a e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/02/2012
-
6. Remodelamento do fígado, pâncreas e tecido adiposo em modelo experimental de síndrome metabólica tratado com telmisartana, sitagliptina e metformina / Hepatic, pancreatic and adipose tissue remodeling in an experimental model of metabolic syndrome treated with telmisartan, sitagliptin and metformin
Pharmacological intervention can minimize or even reverse adverse remodeling due to metabolic syndrome. This work sought to evaluate the effects of monotherapies and combinations of drugs on insulin sensitivity, adipose tissue morphology, pancreatic and hepatic remodelling in C57BL/6 mice fed a high-fat diet. Male C57BL/6 mice were fed a very high-fat diet (
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/06/2010
-
7. Efeito da Sitagliptina nos potenciais evocados (somato-sensitivo e visual) e no controle metabÃlico do diabetes mellitus tipo 2. / Effects of Sitagliptin on the Metabolic Control of Type 2 Diabetes Mellitus.
Diabetes mellitus (DM) à uma sÃndrome associada a secreÃÃo de insulina deficiente, resistÃncia à aÃÃo da insulina ou uma associaÃÃo de ambas. Caracteriza-se por hiperglicemia crÃnica que a longo prazo poderà causar retinopatia, nefropatia, neuropatia perifÃrica e autonÃmica. Este estudo do tipo intervencionista, prospectivo e aberto teve como o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/04/2010
-
8. Análise dos níveis de GLP-1 nos estados de jejum e pósprandial durante a gestação em mulheres não diabéticas
Introdução: As incretinas são hormônios produzidos pelas células intestinais que atuam no pâncreas estimulando a secreção de insulina. O GLP-1 é o principal representante desses hormônios. Estudos revelam que os níveis desse peptídeo estão diminuídos em pacientes com diabete melito tipo 2. Objetivo: Descrever o comportamento do GLP-1 durante a
Publicado em: 2010
-
9. Glucagon-like peptide-1 (GLP-1): a piece of the incretin puzzle.
-
10. Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion
American Diabetes Association.
-
11. Glucose-dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 Modulate β-Cell Chromatin Structure*S⃞
Chromatin can exert a regulatory effect on gene transcription by modulating the access of transcription factors to target genes. In the present study, we examined whether nuclear actions of the incretin hormones, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, involve modulation of β-cell chromatin structure. Stimulation of INS
American Society for Biochemistry and Molecular Biology.
-
12. Stimulation of incretin secretion by dietary lipid: is it dose dependent?
After the ingestion of nutrients, secretion of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by the enteroendocrine cells increases rapidly. Previous studies have shown that oral ingestion of fat stimulates secretion of both incretins; however, it is unclear whether there is a dose-dependent rela
American Physiological Society.