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Mostrando 13-24 de 36917 artigos, teses e dissertações.
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13. Synthesis and Biological Evaluation of Novel 1,3-Benzoxathiol-2-one Sulfonamides against Toxic Activities of the Venom of Bothrops jararaca and Bothrops jararacussu Snakes
This work describes the synthesis of new 1,3-benzoxathiol-2-one sulfonamides and evaluation of their ability to inhibit some in vitro (coagulant, proteolytic and hemolytic) and in vivo (hemorrhagic, edematogenic and lethality) toxic activities of Bothrops jararaca and Bothrops jararacussu venoms. Compounds have been synthesized from the coupling of intermedi
Journal of the Brazilian Chemical Society. Publicado em: 2022
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14. Benzophenone Derivatives Showed Dual Anti-Inflammatory and Antiproliferative Activities by Inhibiting COX Enzymes and Promote Cyclin E Downregulation
Considering the promising antitumor effects of compounds with dual anti-inflammatory and antiproliferative activities, thus benzophenones analogs (2-7) were evaluated on in vivo anti-inflammatory assay and molecular docking analysis. Those with the best molecular docking results were in vitro evaluated on cyclooxygenase (COX) enzymes and tested regarding ant
Journal of the Brazilian Chemical Society. Publicado em: 2022
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15. The Protective Effect of Kaempferol Against Ischemia/Reperfusion Injury Through Activating SIRT3 to Inhibit Oxidative Stress
Abstract Introduction: The objective of this study is to investigate the protective effect of kaempferol against ischemia/reperfusion (IR) injury and the underlying molecular mechanisms. Methods: H9C2 cells were pretreated with kaempferol for 24 hours and further insulted with IR injury. Cell vitality, reactive oxygen species (ROS) level, glutathione (GSH)
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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16. Paired kidney donation: are we going beyond reasonable limits in living-donor transplantation?
Resumo A demanda crescente por rins para transplante requer estratégias para aumentar a oferta de órgãos e evitar longos períodos de espera em lista. O aumento no número de transplantes com doador vivo envolve o crescimento da utilização de doadores não aparentados e a doação renal pareada. A maior parte desses transplantes são realizados nos EUA,
Brazilian Journal of Nephrology. Publicado em: 2022
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17. Evaluation of 10-minute post-injection 11C-PiB PET and its correlation with 18F-FDG PET in older adults who are cognitively healthy, mildly impaired, or with probable Alzheimer’s disease
Objective: Positron emission tomography (PET) allows in vivo evaluation of molecular targets in neurodegenerative diseases, such as Alzheimer’s disease. Mild cognitive impairment is an intermediate stage between normal cognition and Alzheimer-type dementia. In vivo fibrillar amyloid-beta can be detected in PET using [11C]-labeled Pittsburgh compound B (11C
Brazilian Journal of Psychiatry. Publicado em: 2022
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18. Prediction of live weight in growing hair sheep using the body volume formula
RESUMO Devido às condições dos sistemas tradicionais de produção de ovinos, a avaliação do crescimento animal a partir do peso vivo (PV) é limitada pelo alto custo da balança pecuária, bem como pela sofisticada manutenção necessária. Assim, nos últimos anos, as medidas biométricas (MB) têm sido avaliadas como um método indireto e preciso par
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2022
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19. BIOMARCADORES MOLECULARES DE DOENÇAS HUMANAS: CONCEITOS FUNDAMENTAIS, MODELOS DE ESTUDO E APLICAÇÕES CLÍNICAS
Molecular biomarkers correspond to all endogenous or exogenous biomolecules, whose presence or alteration in metabolic pathways indicate the response of a biological system to a disturbance caused by internal or external factors. The search for biomarkers has allowed deepening the knowledge of complex pathophysiological mechanisms of diseases, interactions w
Química Nova. Publicado em: 2022
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20. Prediction of live weight in beef heifers using a body volume formula
RESUMO O objetivo deste estudo foi desenvolver e avaliar os modelos linear, quadrático e alométrico para predizer o peso vivo (PV), usando-se a fórmula do volume corporal (VC) em novilhas mestiças criadas no sudeste do México. O PV (426,25±117,49kg) e o VC (338,05±95,38dm3) foram medidos em 360 novilhas, com idade entre três e 30 meses. Regressões l
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2022
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21. In vitro sperm characteristics and in vivo fertility of sex-sorted and conventional semen in suckled Nelore cows at a traditional schedule for timed-AI with estrus detection
RESUMO O estudo teve como objetivo avaliar características espermáticas in vitro e a taxa de concepção (TC) de sêmen convencional e sexado em um programa de IATF tradicional de vacas Nelore pós-parto. Todas a vacas (n=348) foram submetidas ao mesmo protocolo de IATF à base de estradiol e de progesterona. Após 48 horas da retirada do implante, foi det
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2022
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22. The “Pink panther” in architecture: the transdisciplinary approach and thought without image
Resumo: Como um conhecimento in vivo, a metodologia transdisciplinar (TR) sugere ir além das disciplinas. Segundo Nicolescu, essa metodologia ocorre em distintos níveis de realidade (ontológica), em diferentes níveis de percepção (complexidade) e na lógica do terceiro incluído, que existem simultaneamente. Ao abordar esses níveis, o pesquisador é a
Trans/Form/Ação. Publicado em: 2022
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23. Pavonia Cav. SPECIES (MALVACEAE SENSU LATO) AS SOURCE OF NEW DRUGS: A REVIEW
Pavonia Cav., is a genus in the Malvaceae sensu lato family, containing 271 species with worldwide distribution, although with a higher diversity in America and Asia. Species from this genus are traditionally used in folk medicine with several biological activities, arousing scientific interest on the search for the substances responsible for such activities
Química Nova. Publicado em: 2022
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24. In vivo Administration of Testosterone Propionate in Cattle Analyzed by High Performance Liquid Chromatography-Tandem Mass Spectrometry: An Enzymatic Hydrolysis Study and Drug Abuse Issues
This study involved an animal experiment in which testosterone propionate was intramuscularly injected into four steers, and the ensuing urine samples were analyzed using high-performance liquid chromatography-tandem mass spectrometry. The enzymatic hydrolysis conditions were analyzed using analysis of variance (ANOVA) and response surface methodology employ
Journal of the Brazilian Chemical Society. Publicado em: 2022