Immunoprotection
Mostrando 1-12 de 35 artigos, teses e dissertações.
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1. Imunoproteção de ilhotas pancreáticas microencapsuladas em biomateriais inovadores e seu potencial terapêutico no diabetes mellitus tipo 1 / Immunoprotection of pancreatic islets microencapsulated in inovative biomaterials and its therapeutic potential in type 1 Diabetes Mellitus
Transplantation of microencapsulated islets represents an attractive therapeutical approach to treat type 1 Diabetes Mellitus, accounting for an improved glycemic control and the abolishment of immunosuppressive therapies. However, maintenance of long-term β-cell viability remains a major problem. During islet isolation, the loss of extracellular matrix
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/05/2012
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2. Assessment of a DNA vaccine encoding an anchored-glycosylphosphatidylinositol tegumental antigen complexed to protamine sulphate on immunoprotection against murine schistosomiasis
Protamine sulphate/DNA complexes have been shown to protect DNA from DNase digestion in a lipid system for gene transfer. A DNA-based vaccine complexed to protamine sulphate was used to induce an immune response against Schistosoma mansoni anchored-glycosylphosphatidylinositol tegumental antigen in BALB/c mice. The protection elicited ranged from 33 to 44%.
Memórias do Instituto Oswaldo Cruz. Publicado em: 2007-02
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3. Monoclonal antibodies against LigANI and LigBNI of pathogenic leptospires:production and characterization / Anticorpos monoclonais contra as proteínas LigA e LigB de leptospiras patogênicas:produção e caracterização
Leptospiral immunoglobulin-like (Lig)proteins are exposed on membrane surface of pathogenic Leptospira and may play a role in host cell attachment and invasion during infection.A pair of Ligs,named LigA and LigB,with identical and non-identical polypeptide regions has recently been identified.The two proteins elicit a strong humoral immune response during ac
Publicado em: 2007
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4. Importância da molécula CD28 (molécula co-estimulatória de linfócitos T) na Paracoccidioidomicose pulmonar. / The role of CD28 deficiency, a T cell costimulatory molecule, in pulmonary Paracoccidioidomycosis.
Como a imunoproteção na Paracoccidioidomicose (PCM) é principalmente mediada por células T, investigamos o impacto da deficiência de CD28, molécula co-estimulatória de linfócitos T, na gravidade da infecção primária e secundária pelo Paracoccidioides brasiliensis. Quando comparados a camundongos C57Bl/6 normais (WT), camundongos CD28-deficientes
Publicado em: 2007
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5. Cloning, expression and characterization of an antigenic domain of the a major surface protein recombinant NcSRS2 (Nc1-p43) of Neospora caninum. / Clonagem, expressão e caracterização do domínio antigênico da proteína majoritária de superfície NcRS2 (Nc1-p43) recombinante de Neospera caninum
Neospora caninum is an obligate intracellular protozoan that can infect domestic and wild canids, as well as ruminants and equines. It was described in 1988 as causing neuromuscular alterations and death in dogs. Recently, N. caninum has received considerable attention for its large impact on the dairy industry, given the economic losses related to breeding
Publicado em: 2006
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6. Leishmanial antigens in the diagnosis of active lesions and ancient scars of American tegumentary leishmaniasis patients
Cutaneous biopsies (n = 94) obtained from 88 patients with American tegumentary leishmaniasis were studied by conventional and immunohistochemical techniques. Specimens were distributed as active lesions of cutaneous leishmaniasis (n = 53) (Group I), cicatricial lesions of cutaneous leishmaniasis (n = 35) (Group II) and suggestive scars of healed mucosal lei
Memórias do Instituto Oswaldo Cruz. Publicado em: 2001-10
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7. Stress-induced enhancement of leukocyte trafficking into sites of surgery or immune activation
Effective immunoprotection requires rapid recruitment of leukocytes into sites of surgery, wounding, infection, or vaccination. In contrast to immunosuppressive chronic stressors, short-term acute stressors have immunoenhancing effects. Here, we quantify leukocyte infiltration within a surgical sponge to elucidate the kinetics, magnitude, subpopulation, and
National Academy of Sciences.
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8. mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia
Bacillus anthracis is surrounded by an antiphagocytic polypeptide capsule composed of poly γ-d-glutamic acid (γDPGA). γDPGA has been identified recently as a potential target for vaccine development. Studies of the role of γDPGA in disease have been hampered by the poor Ab response to this antigen and the lack of immunochemical reagents. As a consequence
National Academy of Sciences.
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9. Resistance to meningococcemia apparently conferred by anti-H.8 monoclonal antibody is due to contaminating endotoxin and not to specific immunoprotection.
We evaluated the ability of a monoclonal antibody directed against the common H.8 antigen of pathogenic Neisseria sp. to confer passive protection against meningococcal disease in mice. The apparent protection conferred by antibody purified from tissue culture supernatant was actually the result of endotoxin contamination of buffers and tissue culture media.
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10. Cell-mediated immunoprotection in blastomycosis.
Delayed hypersensitivity can be induced in C57BL/6J mice by two subcutaneous injections of Merthiolate-killed Blastomyces dermatitidis yeast cells in Freund incomplete adjuvant. Development of delayed hypersensitivity peaked at the day 18 post-primary antigen-emulsion injection, as determined by footpad sensitivity tests. Mice rendered hypersensitive to B. d
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11. Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccinia virus vector.
We have constructed a vaccinia virus recombinant that expresses the extracellular domain of the rat neu oncogene-encoded protein, a 185-kDa transmembrane glycoprotein termed p185. Strain NFS mice immunized with this recombinant virus developed a strong antibody response against the neu oncogene product and were fully protected against subsequent tumor challe
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12. Leptospiral Outer Membrane Proteins OmpL1 and LipL41 Exhibit Synergistic Immunoprotection
New vaccine strategies are needed for prevention of leptospirosis, a widespread human and veterinary disease caused by invasive spirochetes belonging to the genus Leptospira. We have examined the immunoprotective capacity of the leptospiral porin OmpL1 and the leptospiral outer membrane lipoprotein LipL41 in the Golden Syrian hamster model of leptospirosis.
American Society for Microbiology.