Immunopathology
Mostrando 1-12 de 192 artigos, teses e dissertações.
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1. Convalescent plasma therapy - a silver lining for COVID-19 management?
ABSTRACT The COVID-19 pandemic has pushed the world towards social, economic, and medical challenges. Scientific research in medicine is the only means to overcome novel and complex diseases like COVID-19. To sum up the therapeutic wild-goose chase, many available antivirals and repurposed drugs have failed to show successful clinical evidence in patient rec
Hematol., Transfus. Cell Ther.. Publicado em: 2021-06
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2. ANIMAL MODELS FOR THE STUDY OF LEISHMANIASIS IMMUNOLOGY
Leishmaniasis remains a major public health problem worldwide and is classified as Category I by the TDR/WHO, mainly due to the absence of control. Many experimental models like rodents, dogs and monkeys have been developed, each with specific features, in order to characterize the immune response to Leishmania species, but none reproduces the pathology obse
Rev. Inst. Med. trop. S. Paulo. Publicado em: 2014-01
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3. Genetics of leprosy reactions: an overview
Type-1 (T1R) and Type-2 (T2R) leprosy reactions (LR), which affect up to 50% of leprosy patients, are aggressive inflammatory episodes of sudden onset and highly variable incidence across populations. LR are often diagnosed concurrently with leprosy, but more frequently occur several months after treatment onset. It is not uncommon for leprosy patients to de
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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4. Lepromatous leprosy patients produce antibodies that recognise non-bilayer lipid arrangements containing mycolic acids
Non-bilayer phospholipid arrangements are three-dimensional structures that form when anionic phospholipids with an intermediate structure of the tubular hexagonal phase II are present in a bilayer of lipids. Antibodies that recognise these arrangements have been described in patients with antiphospholipid syndrome and/or systemic lupus erythematosus and in
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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5. Differential expression of the costimulatory molecules CD86, CD28, CD152 and PD-1 correlates with the host-parasite outcome in leprosy
Leprosy is a spectral disease exhibiting two polar sides, namely, lepromatous leprosy (LL) characterised by impaired T-cell responses and tuberculoid leprosy in which T-cell responses are strong. Proper T-cell activation requires signalling through costimulatory molecules expressed by antigen presenting cells and their ligands on T-cells. We studied the infl
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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6. Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection
We have described a case of a patient with an intriguing association of mucocutaneous leishmaniasis with lepromatous leprosy, two opposite polar forms of these spectral diseases. In the present follow-up study, we investigated the effect of the addition of Mycobacterium leprae antigens on interferon-gamma (IFN-γ) production in Leishmania antigen-stimulated
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-07
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7. Genes hSecurina e VEGF e células endoteliais circulantes como marcadores de angiogênese em portadores de leucemia mielóide crônica / hSecurin and VEGF genes and circulating endothelial cells as markers of angiogenesis in patients with chronic myeloid leukemia
INTRODUCTION: The impact of the increased expression of vascular endothelial growth factor in the course of chronic myeloid leukemia (CML) is still unknown, but there are reports that those patients have higher vascular density in bone marrow than healthy individuals, particularly in blast crisis. Another factor recently associated with increased angiogenesi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/10/2011
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8. Efeito de terapias na modulação do granuloma paracoccidioidomicótico. / Effect of Therapy on Paracoccidioidomicotic Granuloma Modulation.
A paracoccidioidomicose é uma micose sistêmica caracterizada por ser uma doença granulomatosa. As formas benignas da doença são caracterizadas por uma infecção localizada, contendo granulomas compactos com poucos fungos; já nas formas mais graves, ocorre um processo granulomatoso frouxo com focos de necrose e intensa disseminação fúngica. Objetivo
Publicado em: 2010
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9. Células T reguladoras na asma experimental. / Regulatory T cells in the experimental asthma.
Células T reguladoras (Treg) são cruciais na tolerância periférica e no controle da inflamação. Nós usamos dois modelos bem estabelecidos de tolerância de mucosas para a asma alérgica e a tolerância inalatória local induzida pela exposição crônica a OVA para estudar o aparecimento e função das Treg. Nós mostramos que a tolerância nasal dist
Publicado em: 2010
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10. Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice
Vaccines have had an unquestionable impact on public health during the last century. The most likely reason for the success of vaccines is the robust protective properties of specific antibodies. However, antibodies exert a strong selective pressure and many microorganisms, such as the obligatory intracellular parasite Trypanosoma cruzi, have been selected t
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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11. Small intestinal inflammation following oral infection with Toxoplasma gondii does not occur exclusively in C57BL/6 mice: review of 70 reports from the literature
Small intestinal immunopathology following oral infection with tissue cysts of Toxoplasma gondii has been described in C57BL/6 mice. Seven days after infection, mice develop severe small intestinal necrosis and succumb to infection. The immunopathology is mediated by local overproduction of Th1-type cytokines, a so-called "cytokine storm". The immunopathogen
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-03
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12. Immunopathology in ocular toxoplasmosis: facts and clues
Although parasite-mediated host cell lysis is deemed to be an important cause of tissue destruction in ocular toxoplasmosis (OT), the severity of the disease is probably correlated with hypersensitivity and inflammation. Notwithstanding, the mechanisms that regulate the inflammatory process in recurrent OT are poorly understood. Recent evidence has identifie
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-03