Immunohistochemical Biomarkers
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. The Prognostic Roles of PYCR2 and ZBTB18 Expression in Tissues of Colorectal Carcinoma and Non-Neoplastic Tissues: An Immunohistochemical Study
Abstract Background It is important to detect novel biomarkers responsible for the progression and spread of colorectal cancer (CRC) to better evaluate the prognosis of the patients, provide better management, and foster the development of therapeutic targets. In humans, pyrroline-5-carboxylate reductase 2 (PYCR2) is encoded on chromosome 1q42.12, and its m
Journal of Coloproctology (Rio de Janeiro). Publicado em: 2022
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2. Prevalence of ERG expression and PTEN loss in a Brazilian prostate cancer cohort
PTEN is the most commonly inactivated tumor suppressor gene in primary prostate cancer (PCa) and its loss is associated with poor clinical outcomes. ERG rearrangement is a genomic alteration frequently found in PCa and its prognostic significance has yielded mixed results. Although the association of PTEN and ERG biomarkers has potential impact on clinical o
Braz J Med Biol Res. Publicado em: 05/12/2019
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3. Association of the co-expression of SOX2 and Podoplanin in the progression of oral squamous cell carcinomas - an immunohistochemical study
Abstract SOX2 is a transcription factor related to the maintenance of stem cells in a pluripotent state. Podoplanin is a type of transmembrane sialoglycoprotein, which plays an important role in tumor progression and metastasis. This study aims to determine association of SOX2 and podoplanin expression in the progression of oral squamous cell carcinomas and
J. Appl. Oral Sci.. Publicado em: 09/09/2019
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4. Immunohistochemical angiogenic biomarkers in hepatocellular carcinoma and cirrhosis: correlation with pathological features
OBJECTIVE To investigate immunohistochemical markers of angiogenesis and their association with pathological prognostic features in hepatocellular carcinoma and cirrhotic liver. METHODS Vascular endothelial growth factor, CD105, and cyclooxygenase-2 were immunohistochemically detected in 52 hepatocellular carcinoma tissue samples and 48 cirrhotic liver tis
Clinics. Publicado em: 2016-11
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5. Angiotensin-(1–7) inhibits inflammation and oxidative stress to relieve lung injury induced by chronic intermittent hypoxia in rats
Obstructive sleep apnea is associated with inflammation and oxidative stress in lung tissues and can lead to metabolic abnormalities. We investigated the effects of angiotensin1–7 [Ang-(1–7)] on lung injury in rats induced by chronic intermittent hypoxia (CIH). We randomly assigned 32 male Sprague-Dawley rats (180–200 g) to normoxia control (NC), CIH-u
Braz J Med Biol Res. Publicado em: 01/09/2016
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6. Fatores prognósticos em pacientes com carcinoma epidermóide de laringe estádio clínico T3 tratados por cirurgia, radioterapia ou associações terapêuticas / Prognostic factors in patients with cT3 laryngeal squamous cell carcinoma treated by surgery, radiation or multimodality treatment
The decreased survival recorded for patients with laryngeal cancer in the last decades may be related to changes in patterns of management; in literature a recent debate has been dedicated to the management of clinical stage T3 due to the disseminated use of organ preservation strategies (Hoffman, 2006). Although inclusion criteria for organ preservation gro
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/01/2013
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7. Papel dos elementos-traço em neoplasias mamárias: estudo através de técnicas espectroscópicas de fluorescência de raios X e análises imunohistoquímicas / Role of trace elements in breast cancer: Study by X-Ray Fluorescence spectroscopy techniques and Immunohistochemical analysis.
Neste trabalho foi avaliado o papel de elementos-traço em tecidos mamários neoplásicos e seu potencial como marcadores tumorais e fatores prognósticos. As concentrações dos elementos cálcio, ferro, cobre e zinco em tecidos normais e neoplásicos foram determinadas através de técnicas de fluorescência de raios X por dispersão por energia e por refl
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/09/2011
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8. Alterações da PET-FDG na avaliação pré-operatória de pacientes com nódulos tireoidianos e correlação com marcadores imuno-histoquímicos / FDG PET abnormalities in preoperative evaluation of patients with thyroid nodules and association with immunohistochemical biomarkers
INTRODUÇÃO: Cerca de 80% dos nódulos de tireóide com citologia indeterminada são benignos. É possível que a tomografia por emissão de pósitrons (PET) com 2-[18F]- fluoro-2-desoxi-D-glicose (FDG) ajude a identificar quais dessas lesões são malignas. A captação de FDG depende da expressão de GLUTs (transportadores de glicose transmembrana) e hexo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2011
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9. Expression of e-cadherin, n-cadherin and snail and their correlation with clinicopathological variants: an immunohistochemical study of 132 invasive ductal breast carcinomas in Egypt
OBJECTIVE: To evaluate the expression of the cell adhesion molecules E-cadherin and N-cadherin and the transcription factor Snail in invasive ductal breast carcinomas and to determine their relationships with clinicopathological features. METHODS: Immunohistochemistry was used to examine E-cadherin, N-cadherin, and Snail protein expression in 132 invasive br
Clinics. Publicado em: 2011
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10. Effects of diabetes on myocardial capillary density and serum angiogenesis biomarkers in male rats
INTRODUCTION: Cardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptors. METHODS: Twelve
Clinics. Publicado em: 2011
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11. Study of the effects of naphthalene and benzo(a) pyrene in Trachinotus carolinus (Perciformes, Carangidae) using citogenotoxic, histopahological and biochemical biomarkers. / Estudo sobre efeitos do naftaleno e benzo(a) pireno em Trachinotus carolinus (Perciformes, Carangidae) utilizando biomarcadores citogenotóxicos, histopatológicos e bioquímicos
Effects of exposure of fish to pollutants can be identified through stress responses. The present study aims to evaluate the effects of naphthalene and benzo(a)pyrene in Florida pompanos, Trachinotus carolinus. Evidences from citogenotoxical, histopathological and biochemical studies showed that alterations caused by exposures to 0.9 M, 2.7 M and 8.1 M of NA
Publicado em: 2009
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12. EXPRESSÃO DE MARCADORES DE PROLIFERAÇÃO CELULAR E APOPTOSE NO CARCINOMA ESPINOCELULAR DA PELE E CERATOSE ACTÍNICA
O câncer de pele é o mais frequente tipo de câncer humano e mostra aumento de sua incidência nos últimos anos, o que o torna um crescente problema para a saúde pública mundial. Em muitos casos antes do surgimento do carcinoma instala-se uma lesão precursora, ceratose actínica, que pode evoluir para carcinoma espinocelular. Considerando o aumento de
Publicado em: 2009