Immune Adjuvants
Mostrando 1-12 de 172 artigos, teses e dissertações.
-
1. Serological response against bovine herpesvirus and bovine viral diarrhea virus induced by commercial vaccines in Holstein heifers
RESUMO: A vacinação é utilizada como estratégia para a prevenção e controle das doenças reprodutivas, causadas pelos vírus da diarreia viral bovina (BVDV) e herpesvírus bovino tipo 1 (BoHV-1), entretanto, as diversas composições de vacinas comerciais devem ser avaliadas quanto a sua eficiência protetiva mediada por anticorpos (Acs). O objetivo de
Pesq. Vet. Bras.. Publicado em: 02/12/2019
-
2. Inactivated Parapoxvirus ovis as inducer of immunity in silver catfish (Rhamdia quelen)
ABSTRACT Molecules with immune modulating activity are ubiquitously distributed in nature and their impact on aquaculture has been exploited in order to increase fish resistance to pathogens. Here, we investigated the effect of inactivated Parapoxvirus ovis (iPPVO) on blood cells and innate and acquired immune response of silver catfish (Rhamdia quelen). iPP
An. Acad. Bras. Ciênc.. Publicado em: 04/08/2016
-
3. Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
Abstract: Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted. Hence, alternative approaches for VL control are desirable. Some metho
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-08
-
4. Antibody response in silver catfish (Rhamdia quelen) immunized with a model antigen associated with different adjuvants
Adjuvants are essential to boost the immune response to inoculated antigen and play a central role in vaccine development. In this study, we investigated the efficacy of several adjuvants in the production of anti-bovine serum albumin (BSA) antibodies in silver catfish. Two hundred and seventy juvenile silver catfish (60–80 g) of both sexes were intraperit
Braz J Med Biol Res. Publicado em: 25/07/2016
-
5. Evaluation of different adjuvants formulations for bluetongue vaccine
This study investigated the adjuvant potential of W/O/W multiple emulsions and microemulsions, comparing them with traditional aluminum hydroxide and oil-in-water emulsion adjuvants against bluetongue vaccine (BTV). Local inflammatory reactions were assessed in rabbits by measuring the temperature of the animals and the skin thickness at the site of applicat
Braz. arch. biol. technol.. Publicado em: 25/10/2013
-
6. Utilização de sílica mesoporosa como adjuvante em vacinas de vesícula de membrana externa de Neisseria meningitidis / Application of mesoporous silica as a vaccine adjuvant in the outer membrane vesicles vaccination of Neisseria meningitidis
Outer membrane vesicles or OMV are nanoparticles released into the culture medium during bacterial growth resulting from evaginations of the outer membrane. The OMV consists of antigens present in the bacterial outer membrane, like porins and lipooligosaccharides - LOS, these structures provide an immuno-stimulatory effect, and potential target for vaccine p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/02/2012
-
7. Human prophylactic vaccine adjuvants and their determinant role in new vaccine formulations
Adjuvants have been considered for a long time to be an accessory and empirical component of vaccine formulations. However, accumulating evidence of their crucial role in initiating and directing the immune response has increased our awareness of the importance of adjuvant research in the past decade. Nevertheless, the importance of adjuvants still is not fu
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-08
-
8. Pesquisa de novos adjuvantes para vacinas terapêuticas. / Development of new adjuvants for therapeutic vaccine.
A busca por adjuvantes capazes de estimular eficiente resposta imunológica celular representa uma importante contribuição para a pesquisa de vacinas. No presente trabalho avaliamos o potencial adjuvante de flagelinas de Salmonella para a ativação de linfócitos T, com ênfase na ativação de linfócitos T CD8+, em animais imunizados com diferentes estr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/10/2011
-
9. Análise de alterações histopatológicas e celulares em tecidos de camundongos C57BL/6J inoculados com células de melanoma experimental B16F10 por via subcultanea e tratados com o imunomodulador Imiquimod 5%. / Histopathologic analysis of murine C57BL/6J tissues and cells innoculated with B16F10 melanoma cells subcutaneously, treated with the immunemodulator Imiquimod 5%.
Imiquimod é uma imidazoquinolina, agonista do TLR-7, ativador de células dendríticas (DC) e indutor da transcrição de diversas citocinas. O objetivo deste estudo é avaliar o crescimento tumoral, a formação de metástases em órgãos internos, a atividade do sistema imune e o tipo de morte celular induzido devido ao tratamento tópico. Camundongos for
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/10/2011
-
10. Avaliação da virulência micobacteriana e modulação da resposta imune durante a infecção por isolados clínicos de Mycobacterium bovis e Mycobacterium tuberculosis. / Evaluation of the mycobacterial virulence and modulation of the immune response during infection by clinical isolates of Mycobacterium bovis and Mycobacterium tuberculosis.
A tuberculose é considerada um problema emergente de saúde pública. Este estudo tem como objetivo avaliar a associação da patogenicidade/virulência e propriedades imunomoduladoras de isolados clínicos de Mbv (cepas B2 e MP287/03) e Mtb (cepa Beijing 1471), e da cepa de Mtb H37Rv, como referência de virulência. Os isolados, MP287/03 e Beijing 1471, a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/05/2011
-
11. Synergism/complementarity of recombinant adenoviral vectors and other vaccination platforms during induction of protective immunity against malaria
The lack of immunogenicity of most malaria antigens and the complex immune responses required for achieving protective immunity against this infectious disease have traditionally hampered the development of an efficient human malaria vaccine. The current boom in development of recombinant viral vectors and their use in prime-boost protocols that result in en
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
-
12. Trends in adjuvant development for vaccines: DAMPs and PAMPs as potential new adjuvants
Aluminum salts have been widely used in vaccine formulations and, after their introduction more than 80 years ago, only few vaccine formulations using new adjuvants were developed in the last two decades. Recent advances in the understanding of how innate mechanisms influence the adaptive immunity opened up the possibility for the development of new adjuvant
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06