Immediate Early Genes
Mostrando 1-12 de 683 artigos, teses e dissertações.
-
1. Molecular characterization of Brazilian equid herpesvirus type 1 strains based on neuropathogenicity markers
Partial nucleotide sequences of ORF72 (glycoprotein D, gD), ORF64 (infected cell protein 4, ICP4) and ORF30 (DNA polymerase) genes were compared with corresponding sequences of EHV-1 reference strains to characterize the molecular variability of Brazilian strains. Virus isolation assays were applied to 74 samples including visceral tissue, total blood, cereb
Braz. J. Microbiol.. Publicado em: 2015-06
-
2. Immediate expression of c-fos and c-jun mRNA in a model of intestinal autotransplantation and ischemia-reperfusion in situ
OBJECTIVE: Intestinal ischemia-reperfusion injury occurs in several clinical conditions and after intestinal transplantation. The aim of the present study was to investigate the phenomena of apoptosis and cell proliferation in a previously described intestinal ischemia-reperfusion injury autograft model using immunohistochemical markers. The molecular mecha
Clinics. Publicado em: 2015-05
-
3. Effects of ischemic preconditioning in a pig model of large-for-size liver transplantation
OBJECTIVE: In most cases of pediatric liver transplantation, the clinical scenario of large-for-size transplants can lead to hepatic dysfunction and a decreased blood supply to the liver graft. The objective of the present experimental investigation was to evaluate the effects of ischemic preconditioning on this clinical entity. METHODS: Eighteen pigs were
Clinics. Publicado em: 2015-02
-
4. Identificação de receptores moleculares para ligantes detectados pelo Órgão Vomeronasal / Identification of molecular receptors for ligands detected by the Vomeronasal Organ
Uma propriedade fundamental do sistema nervoso em todas as espécies animais e a transformação dos estímulos sensoriais em atividade neural, levando a mudanças comportamentais e endócrinas. Dentre os sistemas sensoriais, o Sistema Olfatório destaca-se por sua complexidade molecular, capacidade de detecção de odores e modulação de comportamentos ina
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
-
5. Immediate response of myocardium to pressure overload includes transient regulation of genes associated with mitochondrial bioenergetics and calcium availability
Ventricular hypertrophy is one of the major myocardial responses to pressure overload (PO). Most studies on early myocardial response focus on the days or even weeks after induction of hypertrophic stimuli. Since mechanotransduction pathways are immediately activated in hearts undergoing increased work load, it is reasonable to infer that the myocardial gene
Genetics and Molecular Biology. Publicado em: 22/01/2010
-
6. Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity
This review addresses the mechanisms of methylmercury (MeHg)- induced neurotoxicity, specifically examining the role of oxidative stress in mediating neuronal damage. A number of critical findings point to a central role for astrocytes in mediating MeHg-induced neurotoxicity as evidenced by the following observations: a) MeHg preferentially accumulates in as
Publicado em: 2010
-
7. Expressão de genes imediatos induzidos por vocalizações em sagüis-comuns (Callithrix jacchus)
Immediate-early genes (IEGs) expression has been widely used as a valuable tool to investigate brain areas activated by specific stimuli. Studies of natural vocalizations, specially in songbirds, have largely benefited from this tool. Here we used IEGs expression to investigate brain areas activated by the hearing of conspecific common marmoset (Callithrix j
Publicado em: 2008
-
8. Expressão de zif-268 durante a aquisição, evocação e extinção de uma memória aversiva
In the behavioral paradigm of discriminative avoidance task, both short and long-term memories have been extensively investigated with behavioral and pharmacological approaches. The aim of the present study was to evaluate, using the abovementioned model, the hippocampal expression of zif-268 - a calcium-dependent immediate early gene involved with synaptic
Publicado em: 2008
-
9. Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity
This review addresses the mechanisms of methylmercury (MeHg)-induced neurotoxicity, specifically examining the role of oxidative stress in mediating neuronal damage. A number of critical findings point to a central role for astrocytes in mediating MeHg-induced neurotoxicity as evidenced by the following observations: a) MeHg preferentially accumulates in ast
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-03
-
10. Efeito do doador de oxido nitrico S-Nitroso-acetilcisteina sobre a sobre a sinalização celular da angiotensina II em coração e cardiomiocitos de ratos / Effect of the nitric oxide donor S-Nitroso-N-Acetylcysteine on angiotensin II signal transduction in heart and cardiomyocites of rats
Angiotensina II (AngII) desempenha um papel importante na gênese da hipertrofia miocárdica. Grande parte do estímulo hipertrófico determinado pela AngII depende da ativação de sinalização intracelular envolvendo membros das famílias de transdutores de sinais mitogen-activated-protein kinase (MAPK) e Janus Kinase (JAK)/ signal transducer and activato
Publicado em: 2005
-
11. Regulação da expressão e ativação do fator de transcrição C-JUN no miocardio de ratos submetido a sobrecarga pressora aguda
The early expression of immediate early genes is a fundamental feature of myocardial hypertrophy. The immediate early gene c-jun codifies a transcription factor that has been assigned to be an important regulator of the hypertrophic response in cardiac myocytes. In the present study we investigated whether pressure overload or phenylephrine treatment stimula
Publicado em: 2003
-
12. The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells: comparison with serum-stimulated 3T3 cells and identification of 41 novel immediate-early genes.
Liver regeneration provides a unique system for analysis of mitogenesis in intact, fully developed animals. Cellular immediate-early genes likely play an important role in cell cycle regulation and have been extensively studied in mitogen-stimulated fibroblasts lymphocytes but not in liver. We have begun to characterize the immediate-early growth response ge