Ifosfamide
Mostrando 13-20 de 20 artigos, teses e dissertações.
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13. A model of hemorrhagic cystitis induced with acrolein in mice
Acrolein is a urinary metabolite of cyclophosphamide and ifosfamide, which has been reported to be the causative agent of hemorrhagic cystitis induced by these compounds. A direct cytotoxic effect of acrolein, however, has not yet been demonstrated. In the present study, the effects of intravesical injection of acrolein and mesna, the classical acrolein chem
Brazilian Journal of Medical and Biological Research. Publicado em: 25/09/2006
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14. Biological monitoring of cyclophosphamide and ifosfamide in urine of hospital personnel occupationally exposed to cytostatic drugs.
The occupational exposure of 21 nurses and pharmacy personnel from eight hospitals to cyclophosphamide and ifosfamide was determined by quantifying the amount of the drugs handled and by measuring the urinary excretion of the unmetabolised substances. Preparing antineoplastic drugs for intravenous treatment was the major task of all study participants. Twent
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15. Bone metabolism and mineralisation after cytotoxic chemotherapy including ifosfamide.
Lumbar spine bone mineral density and bone mineral metabolism were studied in 13 children three months or more after completion of cytotoxic chemotherapy that included ifosfamide given for different malignancies. Blood and urine were analysed for calcium, phosphorus, and magnesium and blood for alkaline phosphatase activity, parathyroid hormone, and 1,25(OH)
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16. Evaluation of the paclitaxel–ifosfamide–cisplatin (TIP) combination in relapsed and/or metastatic cervical cancer
Nature Publishing Group.
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17. Effects of chemotherapy on ultrastructure of oesophageal adenocarcinoma.
AIMS: To compare and contrast the ultrastructural appearance of resected oesophageal adenocarcinomas treated with preoperative chemotherapy with that of non-treated resected controls; and to determine the usefulness of this method in the assessment of the effectiveness of the chemotherapeutic regimen. METHODS: Ten resected oesophageal adenocarcinomas treated
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18. Lack of correlation of P-glycoprotein expression with response to MIC chemotherapy in oesophageal cancer.
The multidrug resistance gene product P-glycoprotein (P-GP) was assessed immunohistochemically (by antibody JSB-1) in biopsy specimens from 27 oesophageal squamous carcinomas and 10 adenocarcinomas before treatment with mitomycin, ifosfamide and cisplatin (MIC). Tumours were assessed following treatment and correlation with response sought. Of the squamous c
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19. Histopathological findings in oesophageal carcinoma with and without preoperative chemotherapy.
AIMS: To investigate the pathological effects of preoperative chemotherapy on oesophageal carcinoma. METHODS: Qualitative and quantitative changes in oesophageal carcinoma after preoperative chemotherapy were assessed by examination of biopsy specimens before treatment and resected specimens. RESULTS: Of 13 patients with adenocarcinoma treated with 5-fluorou
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20. Transport of the new chemotherapeutic agent β-d-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-d-glucose cotransporter SAAT1
For β-d-glucosylisophosphoramide mustard (β-d-Glc-IPM), a new alkylating drug in which isophosphoramide mustard is stabilized, a higher selectivity and lower myelotoxicity was observed than for the currently used cytostatic ifosfamide. Because β-d-Glc-IPM is hydrophilic and does not diffuse passively through the lipid bilayer, we investigated whether a tr
The National Academy of Sciences.