Ifenprodil
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Injeção subaracnoidea da associação ifenprodil e cetamina melhora a ação anti-hiperalgésica da cetamina em cães
RESUMO Com a finalidade de testar se uma dose baixa de ifenprodil pode melhorar a ação anti-hiperalgésica da cetamina em cães, um estudo randomizado prospectivo no formato cross-over foi realizado em oito cães sem raça definida (pesando 16,9±3.7kg). Os animais receberam dois tratamentos distintos: cetamina (0,3mg kg-1; KT) e a associação de ifenpro
Arq. Bras. Med. Vet. Zootec.. Publicado em: 2015-12
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2. TRAXOPRODIL ATENUA AS CONVULSÕES INDUZIDAS POR PENTILENOTETRAZOL / TRAXOPRODIL ATTENUATES PENTYLENETETRAZOL-INDUCED SEIZURES
Há evidências de que as poliaminas facilitam convulsões por modular positivamente os receptores N-metil-D-aspartato (NMDAr), e que os antagonistas seletivos a subunidade NR2B do NMDAr têm atividade anticonvulsivante. Entretanto, permanece indeterminado se o traxoprodil (CP-101,606), um análogo do ifenprodil que age como antagonista seletivo na subunidad
Publicado em: 2010
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3. POLIAMINERGIC AGENTS MODULATE CONTEXTUAL FEAR EXTINCTION IN RATS / AGENTES POLIAMINÉRGICOS MODULAM A EXTINÇÃO DO MEDO CONDICIONADO CONTEXTUAL EM RATOS
Polyamines, such as spermidine and spermine, have been reported to improve memory retention through the activation of N-methyl-D-aspartate receptors (NMDAr). However whether polyamine agonists and antagonists alter extinction remains unclear. In the current study, we investigated whether spermidine and polyamine antagonists that selectively block the NR2B su
Publicado em: 2009
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4. Histamina aumenta a consolidação de memórias aversivas através de um mecanismo dependente da ativação de receptores H2
Várias evidências sugerem que a histamina cerebral está envolvida no processo de consolidação de memórias, mas a real participação do sistema histaminérgico neste processo permanece controversa. Aqui nós mostramos que, quando infundida na região CA1 do hipocampo dorsal de ratos imediatamente pós-treino em esquiva inibitória (EI), mas não depois
Publicado em: 2007
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5. Investigação dos efeitos cardiovasculares centrais do veneno da aranha Phoneutria nigriventer em coelhos anestesiados
The putative central effects of Phoneutria nigriventer venom have been investigated. New Zealand rabbits were anaesthetized, immobilized and artificially ventilated. The arterial pressure (AP), cardiac output (CO), the pressures of the left ventricle, dP/dt max were continuously monitored and systemic vascular resistance (SVR) was calculated from CO values.
Publicado em: 1999
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6. A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.
1. Ifenprodil is a selective, atypical non-competitive antagonist of NMDA receptors that contain the NR2B subunit with an undefined mechanism of action. Ifenprodil is neuroprotective in in vivo models of cerebral ischaemia but lacks many of the undesirable side-effects associated with NMDA antagonist. 2. Using whole-cell voltage-clamp recordings, we have stu
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7. Synaptic NMDA receptors in developing mouse hippocampal neurones: functional properties and sensitivity to ifenprodil.
1. Whole-cell patch-clamp techniques were used to record pharmacologically isolated NMDA receptor-mediated EPSCs (NMDA EPSCs) from CA1 pyramidal cells (PCs) in hippocampal slices from 4-day-old to 36-week-old mice, in order to characterize developmental changes in functional properties and subunit composition of synaptic NMDA receptors. 2. During the first p
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8. Molecular determinants of NMDA receptor function in GABAergic neurones of rat forebrain.
1. The functional and molecular properties of NMDA receptors (NMDA-Rs) were studied in single, visually identified GABAergic medial septal neurones of the rat forebrain using patch clamp, fluorometric Ca2+ measurements and the single-cell reverse transcription-polymerase chain reaction (RT-PCR) technique. 2. Large neurones close to the mid-line of the medial
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9. Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors
Chronic ethanol abuse causes up-regulation of NMDA receptors, which underlies seizures and brain damage upon ethanol withdrawal (EW). Here we show that tissue-plasminogen activator (tPA), a protease implicated in neuronal plasticity and seizures, is induced in the limbic system by chronic ethanol consumption, temporally coinciding with up-regulation of NMDA
National Academy of Sciences.
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10. Blockade of NR2B-Containing NMDA Receptors Prevents BDNF Enhancement of Glutamatergic Transmission in Hippocampal Neurons
Application of brain-derived neurotrophic factor (BDNF) to hippocampal neurons has profound effects on glutamatergic synaptic transmission. Both pre- and postsynaptic actions have been identified that depend on the age and type of preparation. To understand the nature of this diversity, we have begun to examine the mechanisms of BDNF action in cultured disso
Cold Spring Harbor Laboratory Press.
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11. Effects of some excitatory amino acid antagonists and drugs enhancing gamma-aminobutyric acid neurotransmission on pefloxacin-induced seizures in DBA/2 mice.
The behavioral and convulsant effects of pefloxacin (PEFLO), a quinolone derivative, were studied after intraperitoneal (i.p.) administration to Dilute Brown Agouti DBA/2J (DBA/2) mice, a strain genetically susceptible to sound-induced seizures. The anticonvulsant effects of some excitatory amino acid (EAA) antagonists acting at N-methyl-D-aspartate (NMDA) o
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12. Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential
N-methyl-D-aspartate receptors (NMDARs) are ion channels gated by glutamate, the major excitatory neurotransmitter in the mammalian central nervous system (CNS). They are widespread in the CNS and are involved in numerous physiological and pathological processes including synaptic plasticity, chronic pain and psychosis. Aberrant NMDAR activity also plays an
Blackwell Publishing Ltd.